SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3fzv PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 276
LEU A 273
PHE A 149
LEU A 110
ILE A  99
THR A 161
 None
 1.36A 1rx2A-3fzvA:
undetectable		 1rx2A-3fzvA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3fzv PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 276
LEU A 273
LEU A 110
PRO A 111
ILE A  99
THR A 161
 None
 1.40A 2d0kA-3fzvA:
undetectable		 2d0kA-3fzvA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 3fzv PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 MET A 196
MET A 230
PHE A 208
 None
 1.26A 3gn8A-3fzvA:
undetectable		 3gn8A-3fzvA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3fzv PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 147
GLU A 162
LEU A 164
ARG A 295
LEU A 140
 None
 1.41A 3ollA-3fzvA:
undetectable		 3ollA-3fzvA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3fzv PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 198
PRO A 219
LEU A 243
SER A 210
 None
 1.14A 4qknA-3fzvA:
undetectable		 4qknA-3fzvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3fzv PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  99
ASP A 146
LEU A 147
THR A 284
LEU A 283
 None
 0.95A 6b54A-3fzvA:
undetectable		 6b54A-3fzvA:
20.39