SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3fzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		3 / 3 LEU A3492
SER A3494
ASN A3438
 None
 0.76A 1bx4A-3fzyA:
undetectable		 1bx4A-3fzyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.23A 1p6kA-3fzyA:
undetectable		 1p6kA-3fzyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.17A 1p6kB-3fzyA:
undetectable		 1p6kB-3fzyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.27A 1rs6A-3fzyA:
undetectable		 1rs6A-3fzyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.22A 1rs6B-3fzyA:
undetectable		 1rs6B-3fzyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.15A 1rs7B-3fzyA:
undetectable		 1rs7B-3fzyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		3 / 3 TRP A3633
LEU A3592
LYS A3559
 UNX  A 323 (-3.9A)
None
None
 1.19A 1yajK-3fzyA:
undetectable		 1yajK-3fzyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.27A 1zzqA-3fzyA:
undetectable		 1zzqA-3fzyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.20A 1zzqB-3fzyA:
undetectable		 1zzqB-3fzyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.17A 1zzuB-3fzyA:
undetectable		 1zzuB-3fzyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		5 / 12 SER A3487
GLU A3485
ASP A3452
GLY A3453
LYS A3611
 None
None
None
None
IHP  A8000 (-2.9A)
 1.20A 2kceA-3fzyA:
undetectable		 2kceA-3fzyA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ILE A3584
LYS A3511
ARG A3457
SER A3632
 UNX  A 327 (-4.3A)
CL  A   1 ( 4.2A)
IHP  A8000 ( 4.0A)
None
 1.05A 2zw9B-3fzyA:
undetectable		 2zw9B-3fzyA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 7 ALA A3477
ALA A3476
ALA A3480
GLN A3491
 None
 0.69A 3a2qA-3fzyA:
undetectable		 3a2qA-3fzyA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		5 / 12 SER A3569
GLY A3580
GLY A3578
SER A3568
LEU A3531
 None
 1.10A 3axzA-3fzyA:
undetectable		 3axzA-3fzyA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 6 HIS A3435
ASN A3468
ASN A3436
GLU A3467
 None
 1.40A 3galB-3fzyA:
undetectable		 3galB-3fzyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		3 / 3 VAL A3464
VAL A3488
TRP A3514
 None
 0.86A 3l8lA-3fzyA:
undetectable
3l8lB-3fzyA:
undetectable		 3l8lA-3fzyA:
6.33
3l8lB-3fzyA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.30A 3n62A-3fzyA:
undetectable		 3n62A-3fzyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.30A 3n62B-3fzyA:
undetectable		 3n62B-3fzyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.29A 3n66B-3fzyA:
undetectable		 3n66B-3fzyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		5 / 10 LEU A3492
ASP A3469
GLY A3567
ILE A3565
VAL A3464
 None
 0.98A 4dqeB-3fzyA:
undetectable		 4dqeB-3fzyA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8J_A_ADNA401_1
(RNA 3'-TERMINAL
PHOSPHATE CYCLASE)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		5 / 12 GLN A3461
ARG A3513
GLN A3515
ASP A3606
HIS A3483
 None
IHP  A8000 (-2.6A)
IHP  A8000 ( 4.4A)
None
IHP  A8000 (-3.8A)
 1.19A 4o8jA-3fzyA:
0.0		 4o8jA-3fzyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8J_B_ADNB401_1
(RNA 3'-TERMINAL
PHOSPHATE CYCLASE)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		5 / 12 GLN A3461
ARG A3513
GLN A3515
ASP A3606
HIS A3483
 None
IHP  A8000 (-2.6A)
IHP  A8000 ( 4.4A)
None
IHP  A8000 (-3.8A)
 1.14A 4o8jB-3fzyA:
0.1		 4o8jB-3fzyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		3 / 3 ALA A3475
ASN A3478
LEU A3479
 None
 0.45A 5i1nC-3fzyA:
undetectable		 5i1nC-3fzyA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 4 LEU A3508
GLY A3460
SER A3486
SER A3487
 None
 1.17A 5uunA-3fzyA:
undetectable		 5uunA-3fzyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.33A 5vunB-3fzyA:
undetectable		 5vunB-3fzyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3fzy RTX TOXIN RTXA
(Vibrio
cholerae) 		4 / 8 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.33A 5vuoB-3fzyA:
undetectable		 5vuoB-3fzyA:
20.14