SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		5 / 12 ILE C 106
TYR C  82
LEU C  57
LEU C 100
ILE C  78
 None
 1.06A 1fmlB-3g04C:
undetectable		 1fmlB-3g04C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN
THYROTROPIN RECEPTOR
(Homo
sapiens) 		3 / 3 ASN B  58
TYR C  82
SER B 100
 None
 0.94A 2gvcB-3g04B:
undetectable		 2gvcB-3g04B:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		4 / 6 LEU C  64
LEU C  89
ASP C  86
ILE C  44
 None
 1.16A 2rlfB-3g04C:
undetectable
2rlfC-3g04C:
undetectable		 2rlfB-3g04C:
10.43
2rlfC-3g04C:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN
THYROTROPIN RECEPTOR
(Homo
sapiens) 		4 / 7 PHE C 130
ILE C  85
THR C 159
GLY B  98
 None
 0.91A 2v0mB-3g04C:
undetectable		 2v0mB-3g04C:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		4 / 7 PHE C 141
LEU C 156
PHE C 172
GLY C 132
 None
 0.95A 2v0mC-3g04C:
undetectable		 2v0mC-3g04C:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		4 / 8 ILE C 158
LEU C 207
LEU C 213
PHE C 189
 None
 0.87A 2vctA-3g04C:
undetectable		 2vctA-3g04C:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		4 / 8 ILE C 158
LEU C 207
LEU C 213
PHE C 189
 None
 0.85A 2vctB-3g04C:
undetectable		 2vctB-3g04C:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		4 / 8 ILE C 158
LEU C 207
LEU C 213
PHE C 189
 None
 0.92A 2vctC-3g04C:
undetectable		 2vctC-3g04C:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL B 163
VAL B 182
SER B 180
ASN B 197
ASN B 155
 None
 1.44A 2y03A-3g04B:
undetectable		 2y03A-3g04B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		5 / 11 THR C 236
ILE C 216
LEU C 207
PRO C 242
LEU C 246
 None
 1.26A 3a51A-3g04C:
undetectable		 3a51A-3g04C:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		5 / 12 PHE C 197
GLY C 199
GLY C 174
LEU C 175
ASN C 170
 None
None
None
None
NAG  C   1 (-3.2A)
 1.03A 3av6A-3g04C:
undetectable		 3av6A-3g04C:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		5 / 9 LEU C 246
LEU C 231
VAL C 205
ILE C 216
PHE C 197
 None
 1.09A 3freX-3g04C:
undetectable		 3freX-3g04C:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		4 / 8 ILE C 108
ARG C 112
ASN C 161
LEU C 138
 None
 0.84A 3hrdA-3g04C:
undetectable
3hrdB-3g04C:
undetectable		 3hrdA-3g04C:
21.00
3hrdB-3g04C:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU B 189
GLY B 190
ALA B 125
PRO B 126
 None
 0.41A 3huoA-3g04B:
undetectable		 3huoA-3g04B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL B 163
VAL B 182
SER B 180
ASN B 197
ASN B 155
 None
 1.43A 3nyaA-3g04B:
undetectable		 3nyaA-3g04B:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL C 224
LEU C 184
LEU C 202
VAL C 192
ALA C 196
 None
 1.12A 3rr3C-3g04C:
undetectable		 3rr3C-3g04C:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL C 224
LEU C 184
LEU C 202
VAL C 192
ALA C 196
 None
 1.12A 3rr3D-3g04C:
undetectable		 3rr3D-3g04C:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN
(Homo
sapiens) 		5 / 10 VAL B 163
VAL B 182
SER B 180
ASN B 197
ASN B 155
 None
 1.49A 4ldoA-3g04B:
undetectable		 4ldoA-3g04B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3g04 THYROTROPIN RECEPTOR
(Homo
sapiens) 		5 / 12 ILE C 117
LEU C 144
LEU C 156
ILE C 158
THR C 111
 None
 0.98A 4m2xC-3g04C:
undetectable		 4m2xC-3g04C:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL B 163
VAL B 182
SER B 180
ASN B 197
ASN B 155
 None
 1.43A 6h7mB-3g04B:
undetectable		 6h7mB-3g04B:
16.81