SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
3 / 3 THR A 314
PRO A 202
THR A 201
None
0.95A 1dscC-3g05A:
undetectable
1dscC-3g05A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
3 / 3 THR A 201
THR A 314
PRO A 202
None
0.81A 1dscC-3g05A:
undetectable
1dscC-3g05A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 4 VAL A 152
ALA A 368
LEU A 353
PHE A 367
None
1.15A 1q97B-3g05A:
undetectable
1q97B-3g05A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 12 ALA A 392
ALA A 150
LEU A 187
GLY A 388
LEU A 153
None
1.15A 1qabF-3g05A:
undetectable
1qabF-3g05A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
3 / 3 THR A 314
THR A 201
PRO A 203
None
0.87A 1qfiB-3g05A:
undetectable
1qfiB-3g05A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
1.02A 1t85A-3g05A:
undetectable
1t85A-3g05A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.98A 1t87A-3g05A:
undetectable
1t87A-3g05A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 10 LEU A 448
LEU A  66
ILE A 451
GLU A 358
LEU A 389
None
1.25A 1wopA-3g05A:
undetectable
1wopA-3g05A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.96A 1yrcA-3g05A:
undetectable
1yrcA-3g05A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.94A 1yrdA-3g05A:
undetectable
1yrdA-3g05A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
3 / 3 THR A 201
PRO A 203
THR A 314
None
0.70A 209dC-3g05A:
undetectable
209dC-3g05A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 8 THR A  19
GLY A 384
ALA A 380
TYR A 104
None
None
SO4  A 551 (-3.6A)
None
0.80A 2a1hA-3g05A:
undetectable
2a1hB-3g05A:
undetectable
2a1hA-3g05A:
21.49
2a1hB-3g05A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 8 TYR A 104
THR A  19
GLY A 384
ALA A 380
None
None
None
SO4  A 551 (-3.6A)
0.82A 2a1hA-3g05A:
undetectable
2a1hB-3g05A:
undetectable
2a1hA-3g05A:
21.49
2a1hB-3g05A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 12 LEU A 389
LEU A 386
LEU A  66
MET A  28
THR A  32
None
1.25A 2aa6A-3g05A:
undetectable
2aa6A-3g05A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.98A 2cppA-3g05A:
undetectable
2cppA-3g05A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.98A 2feuB-3g05A:
undetectable
2feuB-3g05A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
6 / 12 LEU A 153
GLY A 137
LEU A  35
ILE A 362
LEU A 183
LEU A 187
None
1.35A 2nxeA-3g05A:
undetectable
2nxeA-3g05A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 GLU A 379
GLY A  55
PHE A 227
ILE A  51
None
1.00A 2qmzA-3g05A:
undetectable
2qmzB-3g05A:
undetectable
2qmzA-3g05A:
17.34
2qmzB-3g05A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 6 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.98A 2zawA-3g05A:
undetectable
2zawA-3g05A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.96A 2zaxA-3g05A:
undetectable
2zaxA-3g05A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 5 LEU A  42
GLN A 122
THR A  36
THR A 110
None
1.36A 2zj0C-3g05A:
3.0
2zj0C-3g05A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 4 LEU A  42
GLN A 122
THR A  36
THR A 110
None
1.31A 2zj0D-3g05A:
undetectable
2zj0D-3g05A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.94A 2zwtA-3g05A:
undetectable
2zwtA-3g05A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.95A 2zwuA-3g05A:
undetectable
2zwuA-3g05A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
6 / 12 LEU A 153
GLY A 137
LEU A  35
ILE A 362
LEU A 183
LEU A 187
None
1.34A 3cjtO-3g05A:
3.4
3cjtO-3g05A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.97A 3fwfA-3g05A:
undetectable
3fwfA-3g05A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.96A 3fwfB-3g05A:
undetectable
3fwfB-3g05A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.99A 3fwgB-3g05A:
undetectable
3fwgB-3g05A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.97A 3fwjA-3g05A:
undetectable
3fwjA-3g05A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 11 ALA A 138
LEU A 183
LEU A 365
VAL A 151
ILE A 371
None
1.32A 3jw5A-3g05A:
undetectable
3jw5A-3g05A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.96A 3wrhA-3g05A:
undetectable
3wrhA-3g05A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 6 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.95A 3wrhE-3g05A:
undetectable
3wrhE-3g05A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.96A 3wrjA-3g05A:
undetectable
3wrjA-3g05A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 6 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.95A 3wrjE-3g05A:
undetectable
3wrjE-3g05A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.96A 3wrlA-3g05A:
undetectable
3wrlA-3g05A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.98A 3wrlE-3g05A:
undetectable
3wrlE-3g05A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.96A 3wrmA-3g05A:
undetectable
3wrmA-3g05A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.95A 3wrmF-3g05A:
undetectable
3wrmF-3g05A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 6 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.95A 4ek1A-3g05A:
undetectable
4ek1A-3g05A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 12 GLY A  13
GLY A  18
VAL A 155
THR A 154
LEU A 153
None
SO4  A 551 (-4.8A)
SO4  A 551 ( 4.9A)
SO4  A 551 ( 4.7A)
None
1.21A 4f84A-3g05A:
2.9
4f84A-3g05A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 6 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.95A 4g3rA-3g05A:
undetectable
4g3rA-3g05A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 6 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.98A 4g3rB-3g05A:
undetectable
4g3rB-3g05A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 12 ILE A  11
GLY A 156
GLY A  15
ILE A 371
ALA A 368
None
SO4  A 551 (-2.6A)
SO4  A 551 (-3.2A)
None
None
0.97A 4kicB-3g05A:
3.2
4kicB-3g05A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 6 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
1.00A 4kkyX-3g05A:
undetectable
4kkyX-3g05A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 8 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.94A 4l4aA-3g05A:
undetectable
4l4aA-3g05A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 6 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.98A 4l4cA-3g05A:
undetectable
4l4cA-3g05A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
3 / 3 ARG A 405
ASP A 416
ARG A 436
None
0.99A 4mx0A-3g05A:
undetectable
4mx0A-3g05A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 12 ALA A 368
GLY A 388
ILE A 120
GLY A  14
LEU A  42
None
1.18A 4n48B-3g05A:
undetectable
4n48B-3g05A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 12 ALA A  26
GLN A  30
GLY A 388
ALA A 368
ALA A  21
None
0.96A 4pclA-3g05A:
2.4
4pclA-3g05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 9 ALA A  21
GLY A 369
ALA A 368
ILE A  11
VAL A 155
None
SO4  A 551 ( 3.7A)
None
None
SO4  A 551 ( 4.9A)
0.76A 4r21B-3g05A:
undetectable
4r21B-3g05A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 THR A  95
GLY A  52
ALA A  97
ILE A  74
None
0.84A 4txnA-3g05A:
undetectable
4txnA-3g05A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 THR A  95
GLY A  52
ALA A  97
ILE A  74
None
0.80A 4txnB-3g05A:
undetectable
4txnB-3g05A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 THR A  95
GLY A  52
ALA A  97
ILE A  74
None
0.77A 4txnC-3g05A:
undetectable
4txnC-3g05A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 THR A  95
GLY A  52
ALA A  97
ILE A  74
None
0.81A 4txnD-3g05A:
undetectable
4txnD-3g05A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 12 PRO A 309
VAL A 320
THR A 251
ASN A 248
ILE A 280
None
1.50A 4xe0A-3g05A:
undetectable
4xe0A-3g05A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 8 ALA A 368
GLY A 384
ALA A  21
GLY A  18
None
None
None
SO4  A 551 (-4.8A)
0.69A 4zjzA-3g05A:
undetectable
4zjzA-3g05A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
3 / 3 ARG A 479
TYR A 520
GLU A 476
None
0.64A 4zzbE-3g05A:
undetectable
4zzbE-3g05A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 6 VAL A 495
HIS A 498
LEU A 499
LEU A 523
None
1.04A 5hrqB-3g05A:
undetectable
5hrqI-3g05A:
undetectable
5hrqJ-3g05A:
undetectable
5hrqB-3g05A:
3.45
5hrqI-3g05A:
2.96
5hrqJ-3g05A:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 4 ASN A 310
MET A 331
MET A 328
TYR A 243
None
1.48A 5uc3B-3g05A:
0.0
5uc3B-3g05A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 10 PRO A 203
ILE A 295
PRO A 309
SER A 279
GLY A 311
None
1.48A 5weoA-3g05A:
0.0
5weoD-3g05A:
0.0
5weoA-3g05A:
19.48
5weoD-3g05A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 9 PRO A 203
ILE A 295
PRO A 309
SER A 279
GLY A 311
None
1.47A 5weoB-3g05A:
0.0
5weoC-3g05A:
0.0
5weoB-3g05A:
19.48
5weoC-3g05A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 9 ILE A 295
PRO A 309
SER A 279
GLY A 311
PRO A 203
None
1.48A 5weoA-3g05A:
0.0
5weoD-3g05A:
0.0
5weoA-3g05A:
19.48
5weoD-3g05A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 7 LEU A 365
VAL A 151
VAL A 125
ASP A 127
None
0.99A 5wk9A-3g05A:
undetectable
5wk9A-3g05A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
6 / 12 LEU A 316
PRO A 263
GLU A 344
LEU A 167
GLY A 166
PRO A 317
None
1.47A 5zhmB-3g05A:
undetectable
5zhmB-3g05A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 6 GLN A 323
VAL A 254
GLU A 281
ALA A 342
None
1.16A 6djzB-3g05A:
undetectable
6djzB-3g05A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
4 / 4 LEU A 417
ASP A 349
PRO A 350
ARG A 351
None
1.30A 6fgdA-3g05A:
3.2
6fgdA-3g05A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 11 ALA A  21
ALA A 368
ALA A 387
GLY A  14
GLY A  13
None
0.94A 6hwdK-3g05A:
undetectable
6hwdL-3g05A:
undetectable
6hwdK-3g05A:
10.53
6hwdL-3g05A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
5 / 11 ALA A  21
ALA A 368
ALA A 387
GLY A  14
GLY A  13
None
0.94A 6hwdY-3g05A:
undetectable
6hwdZ-3g05A:
undetectable
6hwdY-3g05A:
10.53
6hwdZ-3g05A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli)
3 / 3 ASP A 127
LEU A 183
ARG A 188
None
0.75A 7dfrA-3g05A:
undetectable
7dfrA-3g05A:
13.68