SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		4 / 7 TRP A 163
LEU A 175
LEU A 149
LEU A  89
 None
 0.81A 1gtiA-3g10A:
undetectable		 1gtiA-3g10A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE A 222
ARG A 254
ILE A 251
ILE A 247
 None
 0.83A 2bu8A-3g10A:
undetectable		 2bu8A-3g10A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 THR A  51
THR A  74
ASN A  78
VAL A  79
ALA A 173
 None
 1.18A 2x2iA-3g10A:
undetectable		 2x2iA-3g10A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 THR A  51
THR A  74
ASN A  78
VAL A  79
ALA A 173
 None
 1.25A 2x2iC-3g10A:
undetectable		 2x2iC-3g10A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.25A 4qvlV-3g10A:
undetectable
4qvlb-3g10A:
undetectable		 4qvlV-3g10A:
19.88
4qvlb-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.24A 4qvlH-3g10A:
undetectable
4qvlN-3g10A:
undetectable		 4qvlH-3g10A:
19.88
4qvlN-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.25A 4qvmV-3g10A:
undetectable
4qvmb-3g10A:
undetectable		 4qvmV-3g10A:
19.88
4qvmb-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.25A 4qvmH-3g10A:
undetectable
4qvmN-3g10A:
undetectable		 4qvmH-3g10A:
19.88
4qvmN-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.23A 4qvnV-3g10A:
undetectable
4qvnb-3g10A:
undetectable		 4qvnV-3g10A:
19.88
4qvnb-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.23A 4qvnH-3g10A:
undetectable
4qvnN-3g10A:
undetectable		 4qvnH-3g10A:
19.88
4qvnN-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.22A 4qvpV-3g10A:
undetectable
4qvpb-3g10A:
undetectable		 4qvpV-3g10A:
19.88
4qvpb-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.20A 4qvpH-3g10A:
undetectable
4qvpN-3g10A:
undetectable		 4qvpH-3g10A:
19.88
4qvpN-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.23A 4qvqV-3g10A:
undetectable
4qvqb-3g10A:
undetectable		 4qvqV-3g10A:
19.88
4qvqb-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.24A 4qvqH-3g10A:
undetectable
4qvqN-3g10A:
undetectable		 4qvqH-3g10A:
19.88
4qvqN-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.22A 4qvwV-3g10A:
undetectable
4qvwb-3g10A:
undetectable		 4qvwV-3g10A:
19.88
4qvwb-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.22A 4qvwH-3g10A:
undetectable
4qvwN-3g10A:
undetectable		 4qvwH-3g10A:
19.88
4qvwN-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.25A 4qw0V-3g10A:
undetectable
4qw0b-3g10A:
undetectable		 4qw0V-3g10A:
19.88
4qw0b-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.25A 4qw0H-3g10A:
undetectable
4qw0N-3g10A:
undetectable		 4qw0H-3g10A:
19.88
4qw0N-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.23A 4qw1V-3g10A:
undetectable
4qw1b-3g10A:
undetectable		 4qw1V-3g10A:
19.88
4qw1b-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.22A 4qw1H-3g10A:
undetectable
4qw1N-3g10A:
undetectable		 4qw1H-3g10A:
19.88
4qw1N-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.26A 4qw3V-3g10A:
undetectable
4qw3b-3g10A:
undetectable		 4qw3V-3g10A:
19.88
4qw3b-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.26A 4qw3H-3g10A:
undetectable
4qw3N-3g10A:
undetectable		 4qw3H-3g10A:
19.88
4qw3N-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.23A 4qwuV-3g10A:
undetectable
4qwub-3g10A:
undetectable		 4qwuV-3g10A:
19.88
4qwub-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.23A 4qwuH-3g10A:
undetectable
4qwuN-3g10A:
undetectable		 4qwuH-3g10A:
19.88
4qwuN-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP A  80
LEU A  75
ILE A 194
PHE A 191
 None
 1.01A 4y4dA-3g10A:
undetectable		 4y4dA-3g10A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A  79
TYR A 170
ALA A 173
 None
 0.39A 4ybnA-3g10A:
undetectable		 4ybnA-3g10A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		3 / 3 THR A 104
HIS A 167
LEU A 219
 None
 0.87A 5axdC-3g10A:
undetectable		 5axdC-3g10A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.30A 5bxnV-3g10A:
undetectable
5bxnb-3g10A:
undetectable		 5bxnV-3g10A:
20.41
5bxnb-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.28A 5bxnH-3g10A:
undetectable
5bxnN-3g10A:
undetectable		 5bxnH-3g10A:
20.41
5bxnN-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.22A 5cz7H-3g10A:
undetectable
5cz7N-3g10A:
undetectable		 5cz7H-3g10A:
19.88
5cz7N-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.25A 5d0xV-3g10A:
undetectable
5d0xb-3g10A:
undetectable		 5d0xV-3g10A:
19.88
5d0xb-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.25A 5d0xH-3g10A:
undetectable
5d0xN-3g10A:
undetectable		 5d0xH-3g10A:
19.88
5d0xN-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		4 / 8 THR A 104
LEU A  91
ILE A  37
LEU A  40
 None
 0.95A 5g48A-3g10A:
undetectable		 5g48A-3g10A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.23A 5l5zV-3g10A:
undetectable
5l5zb-3g10A:
undetectable		 5l5zV-3g10A:
19.88
5l5zb-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.22A 5l5zH-3g10A:
undetectable
5l5zN-3g10A:
undetectable		 5l5zH-3g10A:
19.88
5l5zN-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.23A 5l66V-3g10A:
undetectable
5l66b-3g10A:
undetectable		 5l66V-3g10A:
19.88
5l66b-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A  92
THR A 165
GLY A  88
ALA A  90
THR A 104
 None
 1.24A 5l66H-3g10A:
undetectable
5l66N-3g10A:
undetectable		 5l66H-3g10A:
19.88
5l66N-3g10A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 THR A 165
SER A 239
GLY A 238
ALA A  90
THR A 104
 None
 1.34A 5lf3b-3g10A:
undetectable		 5lf3b-3g10A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 THR A 165
SER A 239
GLY A 238
ALA A  90
THR A 104
 None
 1.35A 5lf3N-3g10A:
undetectable		 5lf3N-3g10A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		3 / 3 TRP A 105
MET A  34
ASN A  35
 None
 1.35A 5uc1B-3g10A:
undetectable		 5uc1B-3g10A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		3 / 3 TRP A 105
MET A  34
ASN A  35
 None
 1.32A 5uc1A-3g10A:
undetectable		 5uc1A-3g10A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 109
ILE A  84
ALA A 241
THR A 104
ILE A  22
 None
 1.11A 5vceA-3g10A:
undetectable		 5vceA-3g10A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A  25
ASP A  24
LEU A 175
LEU A 150
GLY A 238
 None
 1.05A 6b0iB-3g10A:
undetectable		 6b0iB-3g10A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A  25
ASP A  24
LEU A 175
LEU A 150
GLY A 238
 None
 1.04A 6b0lB-3g10A:
undetectable		 6b0lB-3g10A:
12.89