SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g1n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_A_H4BA700_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 1d1vA-3g1nA:
undetectable
1d1vB-3g1nA:
undetectable		 1d1vA-3g1nA:
21.64
1d1vB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.34A 1d1vA-3g1nA:
undetectable
1d1vB-3g1nA:
undetectable		 1d1vA-3g1nA:
21.64
1d1vB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 1d1wA-3g1nA:
undetectable
1d1wB-3g1nA:
undetectable		 1d1wA-3g1nA:
21.64
1d1wB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_A_H4BA600_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 1d1xA-3g1nA:
0.0
1d1xB-3g1nA:
0.0		 1d1xA-3g1nA:
21.64
1d1xB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_A_H4BA1600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 1dm8A-3g1nA:
undetectable
1dm8B-3g1nA:
undetectable		 1dm8A-3g1nA:
21.64
1dm8B-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_A_H4BA1600_1
(NITRIC-OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.28A 1fopA-3g1nA:
undetectable
1fopB-3g1nA:
undetectable		 1fopA-3g1nA:
21.64
1fopB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 11 VAL A4021
ILE A4069
GLU A4053
ILE A4068
PHE A4109
 None
 1.00A 1gx9A-3g1nA:
undetectable		 1gx9A-3g1nA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 TYR A4231
VAL A4118
ILE A4251
LEU A4223
 None
 1.31A 1j96A-3g1nA:
undetectable		 1j96A-3g1nA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 10 LEU A4262
ILE A4320
GLY A4319
GLY A4316
THR A4266
 None
None
None
NA  A5001 ( 4.9A)
None
 0.94A 1k6cA-3g1nA:
undetectable		 1k6cA-3g1nA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.29A 1nseA-3g1nA:
undetectable
1nseB-3g1nA:
undetectable		 1nseA-3g1nA:
21.64
1nseB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 1p6lA-3g1nA:
undetectable
1p6lB-3g1nA:
undetectable		 1p6lA-3g1nA:
21.29
1p6lB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.32A 1p6lA-3g1nA:
undetectable
1p6lB-3g1nA:
undetectable		 1p6lA-3g1nA:
21.29
1p6lB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.28A 1p6mA-3g1nA:
undetectable
1p6mB-3g1nA:
undetectable		 1p6mA-3g1nA:
21.29
1p6mB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.28A 1p6nA-3g1nA:
undetectable
1p6nB-3g1nA:
undetectable		 1p6nA-3g1nA:
21.29
1p6nB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 1q2oA-3g1nA:
undetectable
1q2oB-3g1nA:
undetectable		 1q2oA-3g1nA:
21.29
1q2oB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.32A 1q2oA-3g1nA:
undetectable
1q2oB-3g1nA:
undetectable		 1q2oA-3g1nA:
21.29
1q2oB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 TYR A4078
ASN A4102
TYR A4106
LEU A4080
 None
 0.83A 1qzrA-3g1nA:
undetectable		 1qzrA-3g1nA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 TYR A4078
ASN A4102
TYR A4106
LEU A4080
 None
 0.79A 1qzrB-3g1nA:
undetectable		 1qzrB-3g1nA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4128
TYR A4133
THR A4090
TYR A4127
 None
 1.14A 1rmtB-3g1nA:
undetectable		 1rmtB-3g1nA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 8 PHE A4128
TYR A4133
THR A4090
TYR A4127
 None
 1.10A 1rmtD-3g1nA:
undetectable		 1rmtD-3g1nA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 1rs8A-3g1nA:
undetectable
1rs8B-3g1nA:
undetectable		 1rs8A-3g1nA:
21.29
1rs8B-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 1rs9A-3g1nA:
undetectable
1rs9B-3g1nA:
undetectable		 1rs9A-3g1nA:
21.29
1rs9B-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 1rs9A-3g1nA:
1.9
1rs9B-3g1nA:
undetectable		 1rs9A-3g1nA:
21.29
1rs9B-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 5 PHE A4132
PHE A4081
MET A4073
SER A4070
 None
 1.14A 1wrkB-3g1nA:
undetectable		 1wrkB-3g1nA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 5 PHE A4132
PHE A4081
MET A4073
SER A4070
 None
 1.28A 1wrlC-3g1nA:
undetectable		 1wrlC-3g1nA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 1zzsA-3g1nA:
undetectable
1zzsB-3g1nA:
undetectable		 1zzsA-3g1nA:
21.29
1zzsB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.30A 1zzsA-3g1nA:
undetectable
1zzsB-3g1nA:
undetectable		 1zzsA-3g1nA:
21.29
1zzsB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 10 GLY A4059
LEU A4062
LEU A4061
ILE A4048
ARG A4122
 None
 0.81A 2f8dA-3g1nA:
undetectable		 2f8dA-3g1nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 10 GLY A4059
LEU A4062
LEU A4061
ILE A4048
ARG A4122
 None
 0.78A 2f8dB-3g1nA:
undetectable		 2f8dB-3g1nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 2hx2A-3g1nA:
undetectable
2hx2B-3g1nA:
undetectable		 2hx2A-3g1nA:
21.29
2hx2B-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 2hx2A-3g1nA:
undetectable
2hx2B-3g1nA:
undetectable		 2hx2A-3g1nA:
21.29
2hx2B-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 2nseA-3g1nA:
undetectable
2nseB-3g1nA:
undetectable		 2nseA-3g1nA:
21.64
2nseB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 ILE A4364
ILE A4259
LEU A4262
ILE A4257
 None
 0.85A 2q83A-3g1nA:
undetectable		 2q83A-3g1nA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 TYR A4133
PHE A4128
PHE A4074
ILE A4251
 None
 1.05A 2zseA-3g1nA:
undetectable		 2zseA-3g1nA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 12 LEU A4249
PHE A4299
GLY A4302
ASN A4343
ASP A4346
 None
None
NA  A5001 ( 4.9A)
NA  A5001 (-3.2A)
None
 1.28A 2zznA-3g1nA:
undetectable		 2zznA-3g1nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 12 LEU A4249
PHE A4299
GLY A4302
ASN A4343
ASP A4346
 None
None
NA  A5001 ( 4.9A)
NA  A5001 (-3.2A)
None
 1.27A 2zznB-3g1nA:
undetectable		 2zznB-3g1nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 3dqrA-3g1nA:
undetectable
3dqrB-3g1nA:
undetectable		 3dqrA-3g1nA:
21.38
3dqrB-3g1nA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 3dqsA-3g1nA:
undetectable
3dqsB-3g1nA:
undetectable		 3dqsA-3g1nA:
21.29
3dqsB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 3dqtA-3g1nA:
undetectable
3dqtB-3g1nA:
undetectable		 3dqtA-3g1nA:
21.29
3dqtB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.34A 3dqtA-3g1nA:
undetectable
3dqtB-3g1nA:
undetectable		 3dqtA-3g1nA:
21.29
3dqtB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.37A 3jwxA-3g1nA:
undetectable
3jwxB-3g1nA:
undetectable		 3jwxA-3g1nA:
21.64
3jwxB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.38A 3jwxA-3g1nA:
0.0
3jwxB-3g1nA:
0.0		 3jwxA-3g1nA:
21.64
3jwxB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 3jwyA-3g1nA:
0.0
3jwyB-3g1nA:
0.0		 3jwyA-3g1nA:
21.64
3jwyB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 3jwzA-3g1nA:
undetectable
3jwzB-3g1nA:
undetectable		 3jwzA-3g1nA:
21.64
3jwzB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 3jwzA-3g1nA:
undetectable
3jwzB-3g1nA:
undetectable		 3jwzA-3g1nA:
21.64
3jwzB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Q_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 3n5qA-3g1nA:
0.0
3n5qB-3g1nA:
0.0		 3n5qA-3g1nA:
21.64
3n5qB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 3n5rA-3g1nA:
undetectable
3n5rB-3g1nA:
undetectable		 3n5rA-3g1nA:
21.64
3n5rB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 3n5rA-3g1nA:
undetectable
3n5rB-3g1nA:
undetectable		 3n5rA-3g1nA:
21.64
3n5rB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 3n5tA-3g1nA:
0.9
3n5tB-3g1nA:
0.8		 3n5tA-3g1nA:
21.64
3n5tB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
VAL A4026
TRP A4065
GLU A4033
 None
 1.38A 3n61A-3g1nA:
undetectable
3n61B-3g1nA:
undetectable		 3n61A-3g1nA:
21.38
3n61B-3g1nA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 3n6eA-3g1nA:
0.9
3n6eB-3g1nA:
undetectable		 3n6eA-3g1nA:
21.64
3n6eB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 3n6eA-3g1nA:
0.9
3n6eB-3g1nA:
undetectable		 3n6eA-3g1nA:
21.64
3n6eB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_B_H4BB600_1
('NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 3n6fA-3g1nA:
undetectable
3n6fB-3g1nA:
undetectable		 3n6fA-3g1nA:
21.64
3n6fB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 3n6gA-3g1nA:
undetectable
3n6gB-3g1nA:
undetectable		 3n6gA-3g1nA:
21.64
3n6gB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLD_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.29A 3nldA-3g1nA:
0.0
3nldB-3g1nA:
0.0		 3nldA-3g1nA:
21.64
3nldB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.35A 3nleA-3g1nA:
undetectable
3nleB-3g1nA:
1.9		 3nleA-3g1nA:
21.64
3nleB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 3nlgA-3g1nA:
undetectable
3nlgB-3g1nA:
undetectable		 3nlgA-3g1nA:
21.64
3nlgB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 3nlhA-3g1nA:
undetectable
3nlhB-3g1nA:
undetectable		 3nlhA-3g1nA:
21.64
3nlhB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 3nlhA-3g1nA:
undetectable
3nlhB-3g1nA:
undetectable		 3nlhA-3g1nA:
21.64
3nlhB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.37A 3nliA-3g1nA:
0.0
3nliB-3g1nA:
0.0		 3nliA-3g1nA:
21.64
3nliB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLU_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 3nluA-3g1nA:
0.9
3nluB-3g1nA:
undetectable		 3nluA-3g1nA:
21.64
3nluB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_B_H4BB1011_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.36A 3nosA-3g1nA:
0.0
3nosB-3g1nA:
0.0		 3nosA-3g1nA:
19.83
3nosB-3g1nA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.37A 3pnhA-3g1nA:
0.0
3pnhB-3g1nA:
0.0		 3pnhA-3g1nA:
21.29
3pnhB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.36A 3pnhA-3g1nA:
0.0
3pnhB-3g1nA:
0.0		 3pnhA-3g1nA:
21.29
3pnhB-3g1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 5 TYR A4091
THR A4092
PHE A4132
LEU A4080
 None
 1.38A 3qelC-3g1nA:
undetectable		 3qelC-3g1nA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQP_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.35A 3rqpA-3g1nA:
0.0
3rqpB-3g1nA:
0.0		 3rqpA-3g1nA:
21.68
3rqpB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 4 PHE A4109
TYR A4078
ILE A4136
LEU A4227
 None
 1.49A 3sudA-3g1nA:
undetectable		 3sudA-3g1nA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4299
PHE A4296
THR A4340
PHE A4323
 None
None
NA  A5001 (-4.9A)
None
 1.13A 3vnsA-3g1nA:
undetectable		 3vnsA-3g1nA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 HIS A4326
GLU A4147
ASP A4346
GLU A4162
 None
 1.27A 3vywA-3g1nA:
undetectable		 3vywA-3g1nA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 5 LYS A4014
ILE A4233
LEU A4062
ASP A4120
 None
 1.10A 3wzdA-3g1nA:
undetectable		 3wzdA-3g1nA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 4c3aA-3g1nA:
undetectable
4c3aB-3g1nA:
undetectable		 4c3aA-3g1nA:
21.68
4c3aB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 4carA-3g1nA:
undetectable
4carB-3g1nA:
undetectable		 4carA-3g1nA:
21.68
4carB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4carA-3g1nA:
undetectable
4carB-3g1nA:
undetectable		 4carA-3g1nA:
21.68
4carB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 4cftA-3g1nA:
undetectable
4cftB-3g1nA:
undetectable		 4cftA-3g1nA:
21.68
4cftB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.30A 4cftA-3g1nA:
undetectable
4cftB-3g1nA:
undetectable		 4cftA-3g1nA:
21.68
4cftB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.28A 4ctzA-3g1nA:
0.9
4ctzB-3g1nA:
undetectable		 4ctzA-3g1nA:
21.68
4ctzB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4ctzA-3g1nA:
0.0
4ctzB-3g1nA:
0.0		 4ctzA-3g1nA:
21.68
4ctzB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.34A 4cu0A-3g1nA:
2.0
4cu0B-3g1nA:
undetectable		 4cu0A-3g1nA:
21.68
4cu0B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.34A 4cu0A-3g1nA:
undetectable
4cu0B-3g1nA:
undetectable		 4cu0A-3g1nA:
21.68
4cu0B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.34A 4cwvA-3g1nA:
undetectable
4cwvB-3g1nA:
undetectable		 4cwvA-3g1nA:
21.68
4cwvB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.35A 4cwwA-3g1nA:
1.1
4cwwB-3g1nA:
undetectable		 4cwwA-3g1nA:
21.68
4cwwB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.34A 4cwwA-3g1nA:
1.1
4cwwB-3g1nA:
undetectable		 4cwwA-3g1nA:
21.68
4cwwB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.35A 4cwxA-3g1nA:
undetectable
4cwxB-3g1nA:
undetectable		 4cwxA-3g1nA:
21.68
4cwxB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.34A 4cwxA-3g1nA:
undetectable
4cwxB-3g1nA:
undetectable		 4cwxA-3g1nA:
21.68
4cwxB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 4cwyA-3g1nA:
undetectable
4cwyB-3g1nA:
undetectable		 4cwyA-3g1nA:
21.68
4cwyB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 4cwyA-3g1nA:
undetectable
4cwyB-3g1nA:
undetectable		 4cwyA-3g1nA:
21.68
4cwyB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 4cwzA-3g1nA:
undetectable
4cwzB-3g1nA:
undetectable		 4cwzA-3g1nA:
21.68
4cwzB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4cwzA-3g1nA:
undetectable
4cwzB-3g1nA:
undetectable		 4cwzA-3g1nA:
21.68
4cwzB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.33A 4cx0A-3g1nA:
0.9
4cx0B-3g1nA:
undetectable		 4cx0A-3g1nA:
21.68
4cx0B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.32A 4cx0A-3g1nA:
0.9
4cx0B-3g1nA:
0.0		 4cx0A-3g1nA:
21.68
4cx0B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_A_H4BA1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 4d1oA-3g1nA:
undetectable
4d1oB-3g1nA:
undetectable		 4d1oA-3g1nA:
21.02
4d1oB-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4d1oA-3g1nA:
undetectable
4d1oB-3g1nA:
undetectable		 4d1oA-3g1nA:
21.02
4d1oB-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4d1pA-3g1nA:
undetectable
4d1pB-3g1nA:
undetectable		 4d1pA-3g1nA:
21.02
4d1pB-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 4d34A-3g1nA:
0.0
4d34B-3g1nA:
undetectable		 4d34A-3g1nA:
21.68
4d34B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.32A 4d34A-3g1nA:
0.0
4d34B-3g1nA:
0.0		 4d34A-3g1nA:
21.68
4d34B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.26A 4d35A-3g1nA:
undetectable
4d35B-3g1nA:
undetectable		 4d35A-3g1nA:
21.68
4d35B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 4d36A-3g1nA:
undetectable
4d36B-3g1nA:
undetectable		 4d36A-3g1nA:
21.68
4d36B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4d36A-3g1nA:
undetectable
4d36B-3g1nA:
undetectable		 4d36A-3g1nA:
21.68
4d36B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 4d37A-3g1nA:
undetectable
4d37B-3g1nA:
undetectable		 4d37A-3g1nA:
21.68
4d37B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.28A 4d38A-3g1nA:
undetectable
4d38B-3g1nA:
undetectable		 4d38A-3g1nA:
21.68
4d38B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.34A 4d38A-3g1nA:
undetectable
4d38B-3g1nA:
undetectable		 4d38A-3g1nA:
21.68
4d38B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 4d39A-3g1nA:
undetectable
4d39B-3g1nA:
undetectable		 4d39A-3g1nA:
21.68
4d39B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4d39A-3g1nA:
undetectable
4d39B-3g1nA:
undetectable		 4d39A-3g1nA:
21.68
4d39B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 4d3aA-3g1nA:
undetectable
4d3aB-3g1nA:
undetectable		 4d3aA-3g1nA:
21.68
4d3aB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4d3aA-3g1nA:
0.0
4d3aB-3g1nA:
0.0		 4d3aA-3g1nA:
21.68
4d3aB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 ASP A4087
GLU A4248
ASP A4145
GLU A4149
 NA  A5001 (-3.4A)
None
None
None
 1.17A 4feuB-3g1nA:
undetectable		 4feuB-3g1nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 ASP A4087
GLU A4248
ASP A4145
GLU A4149
 NA  A5001 (-3.4A)
None
None
None
 1.13A 4fevB-3g1nA:
undetectable		 4fevB-3g1nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 ASP A4087
GLU A4248
ASP A4145
GLU A4149
 NA  A5001 (-3.4A)
None
None
None
 1.19A 4fevD-3g1nA:
undetectable		 4fevD-3g1nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 ASP A4087
GLU A4248
ASP A4145
GLU A4149
 NA  A5001 (-3.4A)
None
None
None
 1.20A 4fevF-3g1nA:
undetectable		 4fevF-3g1nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 ASP A4087
GLU A4248
ASP A4145
GLU A4149
 NA  A5001 (-3.4A)
None
None
None
 1.16A 4fewB-3g1nA:
undetectable		 4fewB-3g1nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 8 ASP A4087
GLU A4248
ASP A4145
GLU A4149
 NA  A5001 (-3.4A)
None
None
None
 1.20A 4fewF-3g1nA:
undetectable		 4fewF-3g1nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 8 ASP A4087
GLU A4248
ASP A4145
GLU A4149
 NA  A5001 (-3.4A)
None
None
None
 1.15A 4gkhD-3g1nA:
undetectable		 4gkhD-3g1nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 ASP A4087
GLU A4248
ASP A4145
GLU A4149
 NA  A5001 (-3.4A)
None
None
None
 1.18A 4gkhG-3g1nA:
undetectable		 4gkhG-3g1nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 8 ASP A4087
GLU A4248
ASP A4145
GLU A4149
 NA  A5001 (-3.4A)
None
None
None
 1.20A 4gkiA-3g1nA:
undetectable		 4gkiA-3g1nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_A_H4BA502_1
(SUBUNIT A)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 4imxA-3g1nA:
undetectable
4imxB-3g1nA:
undetectable		 4imxA-3g1nA:
21.73
4imxB-3g1nA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSK_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 4jskA-3g1nA:
0.0
4jskB-3g1nA:
2.0		 4jskA-3g1nA:
21.68
4jskB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 4jslA-3g1nA:
undetectable
4jslB-3g1nA:
undetectable		 4jslA-3g1nA:
21.68
4jslB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 4jsmA-3g1nA:
0.9
4jsmB-3g1nA:
undetectable		 4jsmA-3g1nA:
21.68
4jsmB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.35A 4jsmA-3g1nA:
0.9
4jsmB-3g1nA:
undetectable		 4jsmA-3g1nA:
21.68
4jsmB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 4k5hA-3g1nA:
undetectable
4k5hB-3g1nA:
undetectable		 4k5hA-3g1nA:
21.68
4k5hB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 4k5hA-3g1nA:
undetectable
4k5hB-3g1nA:
undetectable		 4k5hA-3g1nA:
21.68
4k5hB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 4k5iA-3g1nA:
undetectable
4k5iB-3g1nA:
undetectable		 4k5iA-3g1nA:
21.68
4k5iB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.27A 4k5jA-3g1nA:
undetectable
4k5jB-3g1nA:
undetectable		 4k5jA-3g1nA:
21.68
4k5jB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4k5jA-3g1nA:
undetectable
4k5jB-3g1nA:
undetectable		 4k5jA-3g1nA:
21.68
4k5jB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 4k5kA-3g1nA:
undetectable
4k5kB-3g1nA:
undetectable		 4k5kA-3g1nA:
21.68
4k5kB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.34A 4kcpA-3g1nA:
undetectable
4kcpB-3g1nA:
undetectable		 4kcpA-3g1nA:
21.68
4kcpB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4kcpA-3g1nA:
undetectable
4kcpB-3g1nA:
undetectable		 4kcpA-3g1nA:
21.68
4kcpB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 4kcqA-3g1nA:
undetectable
4kcqB-3g1nA:
undetectable		 4kcqA-3g1nA:
21.68
4kcqB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 4kcrA-3g1nA:
undetectable
4kcrB-3g1nA:
undetectable		 4kcrA-3g1nA:
21.68
4kcrB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4kcrA-3g1nA:
undetectable
4kcrB-3g1nA:
undetectable		 4kcrA-3g1nA:
21.68
4kcrB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.33A 4kcsA-3g1nA:
undetectable
4kcsB-3g1nA:
undetectable		 4kcsA-3g1nA:
21.68
4kcsB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4kcsA-3g1nA:
undetectable
4kcsB-3g1nA:
undetectable		 4kcsA-3g1nA:
21.68
4kcsB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.28A 4uh8A-3g1nA:
undetectable
4uh8B-3g1nA:
undetectable		 4uh8A-3g1nA:
21.68
4uh8B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.32A 4uh8A-3g1nA:
undetectable
4uh8B-3g1nA:
undetectable		 4uh8A-3g1nA:
21.68
4uh8B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 4uh9A-3g1nA:
undetectable
4uh9B-3g1nA:
undetectable		 4uh9A-3g1nA:
21.68
4uh9B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 4uh9A-3g1nA:
undetectable
4uh9B-3g1nA:
undetectable		 4uh9A-3g1nA:
21.68
4uh9B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 4uhaA-3g1nA:
undetectable
4uhaB-3g1nA:
undetectable		 4uhaA-3g1nA:
21.68
4uhaB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4uhaA-3g1nA:
undetectable
4uhaB-3g1nA:
undetectable		 4uhaA-3g1nA:
21.68
4uhaB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 4upqA-3g1nA:
undetectable
4upqB-3g1nA:
undetectable		 4upqA-3g1nA:
21.68
4upqB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4upqA-3g1nA:
undetectable
4upqB-3g1nA:
undetectable		 4upqA-3g1nA:
21.68
4upqB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 4uprA-3g1nA:
undetectable
4uprB-3g1nA:
undetectable		 4uprA-3g1nA:
21.68
4uprB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.32A 4uprA-3g1nA:
undetectable
4uprB-3g1nA:
undetectable		 4uprA-3g1nA:
21.68
4uprB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 4upsA-3g1nA:
undetectable
4upsB-3g1nA:
undetectable		 4upsA-3g1nA:
21.68
4upsB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 4upsA-3g1nA:
undetectable
4upsB-3g1nA:
undetectable		 4upsA-3g1nA:
21.68
4upsB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.35A 4uptA-3g1nA:
undetectable
4uptB-3g1nA:
undetectable		 4uptA-3g1nA:
21.68
4uptB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 ILE A4048
PHE A4050
ILE A4068
GLU A4064
 None
 1.32A 4zzcA-3g1nA:
undetectable
4zzcB-3g1nA:
undetectable		 4zzcA-3g1nA:
22.09
4zzcB-3g1nA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 ILE A4048
PHE A4050
ILE A4068
GLU A4064
 None
 1.38A 4zzcB-3g1nA:
undetectable
4zzcC-3g1nA:
undetectable		 4zzcB-3g1nA:
22.09
4zzcC-3g1nA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.28A 5adjA-3g1nA:
undetectable
5adjB-3g1nA:
undetectable		 5adjA-3g1nA:
21.68
5adjB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.34A 5adjA-3g1nA:
undetectable
5adjB-3g1nA:
undetectable		 5adjA-3g1nA:
21.68
5adjB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 5adkA-3g1nA:
undetectable
5adkB-3g1nA:
undetectable		 5adkA-3g1nA:
21.68
5adkB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.29A 5adkA-3g1nA:
undetectable
5adkB-3g1nA:
undetectable		 5adkA-3g1nA:
21.68
5adkB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 5adlA-3g1nA:
0.9
5adlB-3g1nA:
undetectable		 5adlA-3g1nA:
21.68
5adlB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.29A 5adlA-3g1nA:
0.9
5adlB-3g1nA:
undetectable		 5adlA-3g1nA:
21.68
5adlB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 5admA-3g1nA:
undetectable
5admB-3g1nA:
undetectable		 5admA-3g1nA:
21.68
5admB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 5admA-3g1nA:
undetectable
5admB-3g1nA:
undetectable		 5admA-3g1nA:
21.68
5admB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 5adnA-3g1nA:
undetectable
5adnB-3g1nA:
undetectable		 5adnA-3g1nA:
21.68
5adnB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.30A 5adnA-3g1nA:
undetectable
5adnB-3g1nA:
undetectable		 5adnA-3g1nA:
21.68
5adnB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 5 GLY A4302
GLU A4147
HIS A4339
ASP A4145
 NA  A5001 ( 4.9A)
None
None
None
 1.10A 5c0oH-3g1nA:
undetectable		 5c0oH-3g1nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 11 VAL A4300
PHE A4323
ILE A4278
ILE A4325
LEU A4360
 None
 1.07A 5e4dB-3g1nA:
undetectable		 5e4dB-3g1nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.26A 5fj2A-3g1nA:
undetectable
5fj2B-3g1nA:
undetectable		 5fj2A-3g1nA:
21.68
5fj2B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 5fj2A-3g1nA:
undetectable
5fj2B-3g1nA:
undetectable		 5fj2A-3g1nA:
21.68
5fj2B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 5fj3A-3g1nA:
undetectable
5fj3B-3g1nA:
undetectable		 5fj3A-3g1nA:
21.68
5fj3B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 5fj3A-3g1nA:
undetectable
5fj3B-3g1nA:
undetectable		 5fj3A-3g1nA:
21.68
5fj3B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.27A 5fvyA-3g1nA:
undetectable
5fvyB-3g1nA:
undetectable		 5fvyA-3g1nA:
21.68
5fvyB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 5fvyA-3g1nA:
undetectable
5fvyB-3g1nA:
undetectable		 5fvyA-3g1nA:
21.68
5fvyB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 5fvzA-3g1nA:
undetectable
5fvzB-3g1nA:
undetectable		 5fvzA-3g1nA:
21.68
5fvzB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.30A 5fvzA-3g1nA:
0.0
5fvzB-3g1nA:
0.0		 5fvzA-3g1nA:
21.68
5fvzB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		3 / 3 ILE A4234
PRO A4235
ILE A4239
 None
 0.44A 5hw8F-3g1nA:
undetectable		 5hw8F-3g1nA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		3 / 3 THR A4340
PRO A4336
ARG A4334
 NA  A5001 (-4.9A)
None
None
 0.79A 5nd7B-3g1nA:
undetectable		 5nd7B-3g1nA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 12 LEU A4254
GLY A4253
SER A4252
LEU A4247
GLU A4248
 None
 1.21A 5nwvA-3g1nA:
undetectable		 5nwvA-3g1nA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.33A 5uo8C-3g1nA:
0.0
5uo8D-3g1nA:
0.0		 5uo8C-3g1nA:
21.02
5uo8D-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.36A 5uo9C-3g1nA:
0.0
5uo9D-3g1nA:
0.0		 5uo9C-3g1nA:
21.02
5uo9D-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.26A 5uo9C-3g1nA:
undetectable
5uo9D-3g1nA:
undetectable		 5uo9C-3g1nA:
21.02
5uo9D-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 5vv6A-3g1nA:
0.9
5vv6B-3g1nA:
undetectable		 5vv6A-3g1nA:
21.68
5vv6B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 5vv7A-3g1nA:
undetectable
5vv7B-3g1nA:
undetectable		 5vv7A-3g1nA:
21.68
5vv7B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 5vv7A-3g1nA:
undetectable
5vv7B-3g1nA:
undetectable		 5vv7A-3g1nA:
21.68
5vv7B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 5vv8A-3g1nA:
undetectable
5vv8B-3g1nA:
undetectable		 5vv8A-3g1nA:
21.68
5vv8B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 5vv8A-3g1nA:
0.0
5vv8B-3g1nA:
0.0		 5vv8A-3g1nA:
21.68
5vv8B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.34A 5vv9A-3g1nA:
undetectable
5vv9B-3g1nA:
undetectable		 5vv9A-3g1nA:
21.68
5vv9B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.32A 5vv9A-3g1nA:
0.0
5vv9B-3g1nA:
0.0		 5vv9A-3g1nA:
21.68
5vv9B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.34A 5vvaA-3g1nA:
0.1
5vvaB-3g1nA:
undetectable		 5vvaA-3g1nA:
21.68
5vvaB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.35A 5vvaA-3g1nA:
0.0
5vvaB-3g1nA:
0.0		 5vvaA-3g1nA:
21.68
5vvaB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 5vvbA-3g1nA:
undetectable
5vvbB-3g1nA:
0.0		 5vvbA-3g1nA:
21.02
5vvbB-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 5vvbC-3g1nA:
0.0
5vvbD-3g1nA:
0.0		 5vvbC-3g1nA:
21.02
5vvbD-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.33A 5vvcC-3g1nA:
0.0
5vvcD-3g1nA:
0.0		 5vvcC-3g1nA:
21.02
5vvcD-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.25A 5vvcC-3g1nA:
undetectable
5vvcD-3g1nA:
0.0		 5vvcC-3g1nA:
21.02
5vvcD-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.29A 5vvdA-3g1nA:
undetectable
5vvdB-3g1nA:
undetectable		 5vvdA-3g1nA:
21.02
5vvdB-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 5vvdC-3g1nA:
undetectable
5vvdD-3g1nA:
0.0		 5vvdC-3g1nA:
21.02
5vvdD-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.32A 5vvgA-3g1nA:
undetectable
5vvgB-3g1nA:
undetectable		 5vvgA-3g1nA:
21.68
5vvgB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.32A 5vvgA-3g1nA:
0.0
5vvgB-3g1nA:
0.0		 5vvgA-3g1nA:
21.68
5vvgB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.33A 5vvnA-3g1nA:
undetectable
5vvnB-3g1nA:
undetectable		 5vvnA-3g1nA:
21.68
5vvnB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.33A 5vvnA-3g1nA:
undetectable
5vvnB-3g1nA:
undetectable		 5vvnA-3g1nA:
21.68
5vvnB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 6av6A-3g1nA:
undetectable
6av6B-3g1nA:
undetectable		 6av6A-3g1nA:
10.57
6av6B-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.30A 6av6A-3g1nA:
undetectable
6av6B-3g1nA:
undetectable		 6av6A-3g1nA:
10.57
6av6B-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.29A 6av6C-3g1nA:
0.0
6av6D-3g1nA:
0.0		 6av6C-3g1nA:
10.57
6av6D-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.28A 6av6C-3g1nA:
undetectable
6av6D-3g1nA:
undetectable		 6av6C-3g1nA:
10.57
6av6D-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 6av7A-3g1nA:
undetectable
6av7B-3g1nA:
undetectable		 6av7A-3g1nA:
10.57
6av7B-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.30A 6av7A-3g1nA:
0.0
6av7B-3g1nA:
0.0		 6av7A-3g1nA:
10.57
6av7B-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.30A 6av7C-3g1nA:
undetectable
6av7D-3g1nA:
0.0		 6av7C-3g1nA:
10.57
6av7D-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.28A 6av7C-3g1nA:
0.0
6av7D-3g1nA:
0.0		 6av7C-3g1nA:
10.57
6av7D-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_A_H4BA502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.33A 6cieA-3g1nA:
0.0
6cieB-3g1nA:
0.0		 6cieA-3g1nA:
10.57
6cieB-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.31A 6cieA-3g1nA:
undetectable
6cieB-3g1nA:
undetectable		 6cieA-3g1nA:
10.57
6cieB-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.31A 6cieC-3g1nA:
undetectable
6cieD-3g1nA:
undetectable		 6cieC-3g1nA:
10.57
6cieD-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.25A 6cieC-3g1nA:
0.0
6cieD-3g1nA:
0.0		 6cieC-3g1nA:
10.57
6cieD-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.29A 6cifA-3g1nA:
0.0
6cifB-3g1nA:
0.0		 6cifA-3g1nA:
10.57
6cifB-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.30A 6cifC-3g1nA:
undetectable
6cifD-3g1nA:
0.0		 6cifC-3g1nA:
10.57
6cifD-3g1nA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.28A 8nseA-3g1nA:
undetectable
8nseB-3g1nA:
undetectable		 8nseA-3g1nA:
21.64
8nseB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.34A 9nseA-3g1nA:
0.0
9nseB-3g1nA:
0.0		 9nseA-3g1nA:
21.64
9nseB-3g1nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.34A 9nseA-3g1nA:
undetectable
9nseB-3g1nA:
undetectable		 9nseA-3g1nA:
21.64
9nseB-3g1nA:
21.64