SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		6 / 12 GLY A 207
ARG A 206
GLY A 237
HIS A 179
ALA A 231
ILE A 171
 None
 1.30A 1bx4A-3g1wA:
4.7		 1bx4A-3g1wA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		5 / 11 GLY A 144
LEU A 143
TYR A 316
GLY A 320
TYR A 291
 None
 1.41A 1iolA-3g1wA:
5.4		 1iolA-3g1wA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		3 / 3 GLY A 239
ASP A 242
ASN A 235
 None
 0.60A 1vq1A-3g1wA:
4.6		 1vq1A-3g1wA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		5 / 12 GLY A 133
ALA A 134
ASP A 136
ILE A 108
ILE A 117
 None
 0.86A 2ienB-3g1wA:
undetectable		 2ienB-3g1wA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		5 / 10 GLY A 144
ALA A 139
TYR A  56
CYH A  60
LEU A 143
 None
 1.37A 2vd0B-3g1wA:
1.3		 2vd0B-3g1wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		5 / 11 GLY A 133
ALA A 134
ASP A 136
ILE A 108
ILE A 117
 None
 1.00A 3ektD-3g1wA:
undetectable		 3ektD-3g1wA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		5 / 10 GLY A 133
ALA A 134
ASP A 136
ILE A 108
ILE A 117
 None
 0.95A 3ttpA-3g1wA:
undetectable		 3ttpA-3g1wA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		5 / 12 ILE A 171
GLY A 241
GLY A 237
ILE A 253
ARG A 249
 None
 1.00A 4kicB-3g1wA:
2.8		 4kicB-3g1wA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		4 / 8 GLY A 102
ILE A 127
LEU A 292
LEU A 295
 None
 0.82A 4mwzB-3g1wA:
undetectable		 4mwzB-3g1wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		5 / 12 GLY A 133
ALA A 134
ASP A 136
ILE A 108
ILE A 117
 None
 0.91A 4njvD-3g1wA:
undetectable		 4njvD-3g1wA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		5 / 12 GLY A 241
GLY A 239
GLY A 236
ASN A 235
ALA A 250
 None
 1.01A 4uciA-3g1wA:
undetectable		 4uciA-3g1wA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		5 / 12 GLY A 241
GLY A 239
GLY A 236
ASN A 235
ALA A 250
 None
 1.01A 4uciB-3g1wA:
undetectable		 4uciB-3g1wA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		4 / 7 GLN A 180
LEU A 177
ALA A 107
LEU A 113
 None
 1.06A 5nwvA-3g1wA:
undetectable		 5nwvA-3g1wA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		5 / 12 GLY A 236
GLY A 205
ASP A 208
SER A 257
ILE A 255
 None
 0.90A 6ectA-3g1wA:
2.9		 6ectA-3g1wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3g1w SUGAR ABC
TRANSPORTER
(Bacillus
halodurans) 		6 / 12 LEU A 219
GLY A 236
GLY A 205
ASP A 208
SER A 257
ILE A 255
 None
 1.31A 6ecxA-3g1wA:
3.1		 6ecxA-3g1wA:
20.00