SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A   7
ALA A 124
LEU A 101
LEU A 143
PHE A  37
 None
 1.03A 1bsxA-3g23A:
undetectable		 1bsxA-3g23A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A   7
ALA A 124
LEU A 101
LEU A 143
PHE A  37
 None
 1.03A 1bsxB-3g23A:
undetectable		 1bsxB-3g23A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		4 / 6 SER A 237
VAL A 238
LEU A 221
GLU A 191
 None
 0.58A 1fduD-3g23A:
5.1		 1fduD-3g23A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A   9
PHE A  42
ALA A  49
VAL A  22
ILE A  23
 None
 1.00A 1fm6U-3g23A:
undetectable		 1fm6U-3g23A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 107
THR A 108
ALA A 165
GLY A  76
HIS A 261
 None
 1.24A 1nbiC-3g23A:
undetectable		 1nbiC-3g23A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 107
THR A 108
ALA A 165
GLY A  76
HIS A 261
 None
 1.23A 1nbiD-3g23A:
undetectable		 1nbiD-3g23A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 106
TYR A 103
GLY A 107
LEU A 110
PHE A 270
 None
 1.35A 1vpoH-3g23A:
undetectable
1vpoL-3g23A:
undetectable		 1vpoH-3g23A:
23.36
1vpoL-3g23A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 168
LEU A 171
LEU A 174
LEU A 183
LEU A 219
 None
 1.26A 1zucB-3g23A:
undetectable		 1zucB-3g23A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		3 / 3 SER A 137
THR A 142
PHE A  37
 None
 0.74A 2x91A-3g23A:
undetectable		 2x91A-3g23A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		3 / 3 MET A 189
VAL A 200
GLU A 239
 None
 0.80A 2x9gA-3g23A:
3.9		 2x9gA-3g23A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 TYR A  78
ARG A  55
GLY A  76
ASN A 167
ASP A 226
 None
 1.46A 2zznB-3g23A:
undetectable		 2zznB-3g23A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		3 / 3 CYH A  41
PHE A  14
PHE A  42
 None
 0.87A 3cr5X-3g23A:
undetectable		 3cr5X-3g23A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 10 ALA A   9
PHE A  42
ALA A  49
VAL A  22
ILE A  23
 None
 1.00A 3falA-3g23A:
undetectable		 3falA-3g23A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 10 PRO A  10
MET A 126
SER A 104
GLY A  76
GLY A  77
 None
None
None
None
SO4  A 276 ( 4.6A)
 1.33A 3ixlA-3g23A:
undetectable		 3ixlA-3g23A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		4 / 7 GLY A  76
GLY A  77
SER A 104
HIS A 261
 None
SO4  A 276 ( 4.6A)
None
None
 0.57A 3o9mA-3g23A:
undetectable		 3o9mA-3g23A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		4 / 6 GLY A  76
GLY A  77
SER A 104
HIS A 261
 None
SO4  A 276 ( 4.6A)
None
None
 0.59A 3o9mB-3g23A:
3.0		 3o9mB-3g23A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 112
ALA A 111
LEU A 174
ALA A  84
LEU A 183
 None
 1.04A 3uvvB-3g23A:
undetectable		 3uvvB-3g23A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		4 / 7 THR A 142
HIS A 123
ASN A 265
TYR A 103
 None
 1.38A 4a3uB-3g23A:
undetectable		 4a3uB-3g23A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		4 / 6 ARG A 132
GLY A 135
PRO A 125
HIS A 123
 None
 0.76A 4lajA-3g23A:
undetectable
4lajB-3g23A:
undetectable		 4lajA-3g23A:
20.38
4lajB-3g23A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 9 VAL A 164
ALA A 163
GLY A 107
PHE A 166
SER A 121
 None
 1.34A 4mmfA-3g23A:
undetectable		 4mmfA-3g23A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 9 VAL A 164
ALA A 163
GLY A 107
PHE A 166
SER A 121
 None
 1.32A 4mmfB-3g23A:
undetectable		 4mmfB-3g23A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		4 / 5 ARG A  55
GLY A  79
ALA A  80
GLY A  77
 None
None
None
SO4  A 276 ( 4.6A)
 0.85A 4u9uA-3g23A:
undetectable		 4u9uA-3g23A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		4 / 5 ARG A  55
GLY A  79
ALA A  80
GLY A  77
 None
None
None
SO4  A 276 ( 4.6A)
 0.77A 4u9uB-3g23A:
undetectable		 4u9uB-3g23A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 PHE A 166
GLY A 260
ILE A 259
ALA A 111
LEU A 180
 None
 1.03A 5e72A-3g23A:
undetectable		 5e72A-3g23A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A 267
PHE A  73
ALA A 111
LEU A 110
ALA A 106
 None
 1.25A 5oy02-3g23A:
undetectable		 5oy02-3g23A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		4 / 5 MET A 173
TYR A  78
GLY A  77
GLY A  76
 None
None
SO4  A 276 ( 4.6A)
None
 0.78A 5x7pA-3g23A:
undetectable		 5x7pA-3g23A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3g23 LD-CARBOXYPEPTIDASE
A
(Novosphingobium
aromaticivorans) 		4 / 6 MET A 173
TYR A  78
GLY A  77
GLY A  76
 None
None
SO4  A 276 ( 4.6A)
None
 0.76A 5x7pB-3g23A:
undetectable		 5x7pB-3g23A:
11.72