SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 7 SER A 428
ARG A 419
TYR A 290
LEU A 304
 None
 0.99A 1ibgL-3g2fA:
undetectable		 1ibgL-3g2fA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 6 ILE A 209
VAL A 217
ILE A 257
ILE A 329
 ADP  A 900 (-4.6A)
ADP  A 900 (-4.3A)
None
None
 0.66A 1uwhA-3g2fA:
24.8		 1uwhA-3g2fA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 6 ILE A 209
VAL A 217
ILE A 257
ILE A 329
 ADP  A 900 (-4.6A)
ADP  A 900 (-4.3A)
None
None
 0.66A 1uwhB-3g2fA:
24.8		 1uwhB-3g2fA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 7 ILE A 209
LYS A 230
ILE A 257
ILE A 329
 ADP  A 900 (-4.6A)
ADP  A 900 (-2.8A)
None
None
 0.70A 1uwjA-3g2fA:
6.5		 1uwjA-3g2fA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		5 / 9 VAL A 217
ALA A 228
MET A 279
GLY A 285
LEU A 340
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
 0.55A 1xbbA-3g2fA:
27.7		 1xbbA-3g2fA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		8 / 11 GLY A 210
GLY A 212
VAL A 217
ALA A 228
MET A 279
TYR A 281
SER A 286
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
None
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.76A 2evaA-3g2fA:
27.1		 2evaA-3g2fA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 12 GLY A 210
VAL A 217
ALA A 228
MET A 279
TYR A 281
ASN A 338
 ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
None
MG  A 901 ( 2.8A)
 0.85A 2fumC-3g2fA:
23.5		 2fumC-3g2fA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 12 ALA A 228
LYS A 230
GLU A 243
LEU A 277
GLY A 285
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
 0.68A 2itoA-3g2fA:
26.1		 2itoA-3g2fA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		8 / 12 VAL A 217
ALA A 228
LYS A 230
GLU A 243
LEU A 277
GLY A 285
LEU A 340
ASP A 351
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.79A 2ityA-3g2fA:
26.1		 2ityA-3g2fA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 VAL A 217
ALA A 228
LYS A 230
GLU A 243
GLY A 285
LEU A 340
ASP A 351
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.73A 2itzA-3g2fA:
26.1		 2itzA-3g2fA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		8 / 12 ILE A 209
ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.74A 2y6oA-3g2fA:
19.7		 2y6oA-3g2fA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		10 / 12 GLY A 210
GLY A 212
GLY A 215
VAL A 217
ALA A 228
LYS A 230
MET A 279
SER A 286
ASN A 338
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-3.7A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 (-3.6A)
ADP  A 900 (-3.6A)
MG  A 901 ( 2.8A)
ADP  A 900 (-4.6A)
 0.75A 3eygA-3g2fA:
27.8		 3eygA-3g2fA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		10 / 12 GLY A 210
GLY A 212
GLY A 215
VAL A 217
LYS A 230
MET A 279
SER A 286
ASN A 338
LEU A 340
ASP A 351
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-3.7A)
ADP  A 900 (-4.3A)
ADP  A 900 (-2.8A)
ADP  A 900 (-3.6A)
ADP  A 900 (-3.6A)
MG  A 901 ( 2.8A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.88A 3eygA-3g2fA:
27.8		 3eygA-3g2fA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		9 / 12 GLY A 210
GLY A 212
GLY A 215
VAL A 217
ALA A 228
LYS A 230
MET A 279
TYR A 281
SER A 286
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-3.7A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 (-3.6A)
None
ADP  A 900 (-3.6A)
 0.73A 3fupA-3g2fA:
21.2		 3fupA-3g2fA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		8 / 12 GLY A 210
GLY A 212
VAL A 217
ALA A 228
MET A 279
TYR A 281
SER A 286
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
None
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.77A 3fupA-3g2fA:
21.2		 3fupA-3g2fA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 GLY A 210
GLY A 212
VAL A 217
ALA A 228
LYS A 230
MET A 279
TYR A 281
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 (-3.6A)
None
 0.53A 3fupB-3g2fA:
27.2		 3fupB-3g2fA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 6 MET A 252
ILE A 329
HIS A 331
ILE A 349
 None
 0.58A 3hegA-3g2fA:
19.2		 3hegA-3g2fA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.72A 3k54A-3g2fA:
25.2		 3k54A-3g2fA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 6 LEU A 476
SER A 475
ILE A 480
CYH A 483
 None
 0.86A 3ko0B-3g2fA:
0.4		 3ko0B-3g2fA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 6 LEU A 476
SER A 475
ILE A 480
CYH A 483
 None
 0.92A 3ko0S-3g2fA:
0.4		 3ko0S-3g2fA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 GLY A 210
GLY A 212
VAL A 217
ALA A 228
LYS A 230
TYR A 281
SER A 286
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
None
ADP  A 900 (-3.6A)
 0.65A 3lxnA-3g2fA:
27.8		 3lxnA-3g2fA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 GLY A 210
GLY A 212
VAL A 217
ALA A 228
TYR A 281
SER A 286
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
None
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.55A 3lxnA-3g2fA:
27.8		 3lxnA-3g2fA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		5 / 9 ILE A 209
ALA A 228
LYS A 230
GLY A 285
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
 0.63A 3miyB-3g2fA:
19.5		 3miyB-3g2fA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 7 ALA A 400
VAL A 387
VAL A 404
LEU A 401
 EDO  A   5 (-3.4A)
None
None
CAS  A 397 ( 3.6A)
 0.83A 3o14A-3g2fA:
undetectable		 3o14A-3g2fA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 5 ASP A 199
LEU A 200
ILE A 261
PHE A 260
 None
 1.15A 3s3vA-3g2fA:
undetectable		 3s3vA-3g2fA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 VAL A 217
ALA A 228
LYS A 230
LEU A 277
MET A 279
GLY A 285
LEU A 340
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
None
ADP  A 900 (-3.6A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
 0.87A 3ug2A-3g2fA:
21.3		 3ug2A-3g2fA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 ILE A 209
GLY A 212
GLY A 215
VAL A 217
ALA A 228
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.0A)
ADP  A 900 (-3.7A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-4.6A)
None
 1.06A 3v5wA-3g2fA:
7.1		 3v5wA-3g2fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 12 ILE A 209
GLY A 212
VAL A 217
ALA A 228
LYS A 230
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 (-4.6A)
 0.70A 3v5wA-3g2fA:
7.1		 3v5wA-3g2fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 9 VAL A 217
ALA A 228
MET A 279
GLY A 285
LEU A 340
ASP A 351
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.64A 4ansA-3g2fA:
18.4		 4ansA-3g2fA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 5 VAL A 217
ILE A 257
TYR A 281
ILE A 349
 ADP  A 900 (-4.3A)
None
None
None
 0.58A 4c8bA-3g2fA:
24.1		 4c8bA-3g2fA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		8 / 11 GLY A 210
GLY A 212
VAL A 217
ALA A 228
TYR A 281
GLY A 285
SER A 286
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.78A 4ckiA-3g2fA:
29.0		 4ckiA-3g2fA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 10 GLY A 210
VAL A 217
ALA A 228
TYR A 281
SER A 286
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
None
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.59A 4ckjA-3g2fA:
28.5		 4ckjA-3g2fA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 10 ILE A 209
ALA A 228
MET A 279
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.87A 4ks8A-3g2fA:
26.7		 4ks8A-3g2fA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		3 / 3 ARG A 459
GLU A 481
PHE A 462
 None
 0.87A 4kszA-3g2fA:
undetectable		 4kszA-3g2fA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 7 VAL A 217
ALA A 228
MET A 279
LEU A 340
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.69A 4l9iA-3g2fA:
18.5		 4l9iA-3g2fA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 8 GLY A 212
VAL A 217
ALA A 228
LYS A 230
MET A 279
LEU A 340
 ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.65A 4l9iB-3g2fA:
22.4		 4l9iB-3g2fA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		8 / 12 VAL A 217
ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
LEU A 340
ASP A 351
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.82A 4mxoB-3g2fA:
20.1		 4mxoB-3g2fA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		8 / 12 VAL A 217
ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
LEU A 340
ASP A 351
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.67A 4mxyA-3g2fA:
27.1		 4mxyA-3g2fA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 VAL A 217
ALA A 228
GLU A 243
TYR A 281
GLY A 285
LEU A 340
ASP A 351
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.63A 4mxyB-3g2fA:
20.7		 4mxyB-3g2fA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		8 / 12 VAL A 217
ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
LEU A 340
ASP A 351
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.67A 4mxzA-3g2fA:
27.1		 4mxzA-3g2fA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 VAL A 217
ALA A 228
GLU A 243
TYR A 281
GLY A 285
LEU A 340
ASP A 351
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.63A 4mxzB-3g2fA:
20.7		 4mxzB-3g2fA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		3 / 3 ASP A 405
ASN A 338
SER A 375
 None
MG  A 901 ( 2.8A)
None
 0.82A 4obwA-3g2fA:
undetectable		 4obwA-3g2fA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 12 ILE A 209
GLY A 210
VAL A 217
ALA A 228
TYR A 281
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
None
ADP  A 900 (-4.6A)
 0.62A 4qmzA-3g2fA:
26.4		 4qmzA-3g2fA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 9 VAL A 217
LYS A 230
TYR A 281
ARG A 332
LEU A 340
ILE A 349
 ADP  A 900 (-4.3A)
ADP  A 900 (-2.8A)
None
None
ADP  A 900 (-4.6A)
None
 0.81A 4v01B-3g2fA:
19.0		 4v01B-3g2fA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 6 LYS A 230
PHE A 260
SER A 286
ASP A 351
 ADP  A 900 (-2.8A)
None
ADP  A 900 (-3.6A)
ADP  A 900 ( 2.7A)
 0.80A 5hesA-3g2fA:
8.7		 5hesA-3g2fA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 ILE A 209
ALA A 228
GLU A 243
TYR A 281
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.52A 5i9xA-3g2fA:
25.3		 5i9xA-3g2fA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		8 / 12 ILE A 209
ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.65A 5i9yA-3g2fA:
15.1		 5i9yA-3g2fA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 9 ILE A 209
GLY A 210
VAL A 217
ALA A 228
MET A 279
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.99A 5lw1B-3g2fA:
21.4		 5lw1B-3g2fA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		5 / 9 GLY A 210
VAL A 217
ALA A 228
MET A 279
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.92A 5lw1H-3g2fA:
21.5		 5lw1H-3g2fA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		9 / 12 GLU A 207
ILE A 209
GLY A 210
VAL A 217
ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
 None
ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
 0.83A 5mafA-3g2fA:
24.2		 5mafA-3g2fA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 8 GLU A 415
VAL A 339
GLY A 410
LEU A 409
 None
 1.00A 5sxtB-3g2fA:
undetectable		 5sxtB-3g2fA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		4 / 8 GLU A 415
VAL A 339
GLY A 410
LEU A 409
 None
 1.00A 5syjB-3g2fA:
undetectable		 5syjB-3g2fA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 12 GLU A 207
ALA A 228
GLU A 243
TYR A 281
GLY A 285
ASP A 351
 None
ADP  A 900 (-3.4A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 ( 2.7A)
 1.03A 5vc3A-3g2fA:
11.1		 5vc3A-3g2fA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 12 GLU A 207
ILE A 209
ALA A 228
TYR A 281
GLY A 285
ASP A 351
 None
ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 ( 2.7A)
 1.01A 5vc3A-3g2fA:
11.1		 5vc3A-3g2fA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 12 GLU A 207
ILE A 209
GLY A 210
ALA A 228
TYR A 281
GLY A 285
 None
ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.4A)
None
ADP  A 900 ( 4.2A)
 1.01A 5vc3A-3g2fA:
11.1		 5vc3A-3g2fA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		6 / 12 VAL A 217
ALA A 228
LYS A 230
MET A 279
GLY A 285
LEU A 340
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 (-3.6A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
 0.79A 5yu9D-3g2fA:
24.7		 5yu9D-3g2fA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		3 / 3 TYR A 281
LEU A 340
ASP A 351
 None
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.77A 5zv2B-3g2fA:
24.2		 5zv2B-3g2fA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		3 / 3 LEU A 492
GLY A 410
PHE A 462
 CAS  A 496 ( 4.4A)
None
None
 0.63A 6exiC-3g2fA:
undetectable		 6exiC-3g2fA:
12.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 ILE A 209
VAL A 217
ALA A 228
LYS A 230
GLU A 243
GLY A 285
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
 0.75A 6fnmA-3g2fA:
21.0		 6fnmA-3g2fA:
30.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens) 		7 / 12 VAL A 217
ALA A 228
LYS A 230
GLU A 243
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.67A 6fnmA-3g2fA:
21.0		 6fnmA-3g2fA:
30.99