SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		4 / 7 GLU A 144
LEU A 145
MET A 123
GLU A  92
 SAH  A 500 (-3.8A)
None
SAH  A 500 (-4.3A)
SAH  A 500 (-2.8A)
 1.08A 1linA-3g2pA:
undetectable		 1linA-3g2pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		4 / 4 SER A 139
ILE A 142
VAL A 268
THR A  60
 None
 1.00A 1u70A-3g2pA:
undetectable		 1u70A-3g2pA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		4 / 5 GLN A 120
THR A  95
ALA A  99
ARG A 102
 None
 1.44A 2qhfA-3g2pA:
undetectable		 2qhfA-3g2pA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		5 / 12 LEU A 171
GLN A 237
ALA A 270
SER A 245
TYR A 154
 None
 1.45A 3apwB-3g2pA:
undetectable		 3apwB-3g2pA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		7 / 12 ALA A  71
GLY A  73
LEU A  93
SER A  94
MET A 123
SER A 141
LEU A 145
 SAH  A 500 (-3.1A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.6A)
SAH  A 500 ( 4.9A)
SAH  A 500 (-4.3A)
SAH  A 500 (-3.0A)
None
 0.67A 3bxoA-3g2pA:
19.0		 3bxoA-3g2pA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		6 / 12 ALA A  71
GLY A  73
LEU A  93
SER A  94
MET A 123
SER A 141
 SAH  A 500 (-3.1A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.6A)
SAH  A 500 ( 4.9A)
SAH  A 500 (-4.3A)
SAH  A 500 (-3.0A)
 0.59A 3bxoB-3g2pA:
18.9		 3bxoB-3g2pA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G2O_A_SAMA500_0
(PCZA361.24)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		12 / 12 GLU A  69
ALA A  71
GLY A  73
LEU A  77
LEU A  91
LEU A  93
SER A  94
MET A 123
SER A 138
GLY A 140
SER A 141
GLU A 144
 SAH  A 500 (-4.2A)
SAH  A 500 (-3.1A)
SAH  A 500 (-3.2A)
SAH  A 500 (-4.1A)
None
SAH  A 500 (-3.6A)
SAH  A 500 ( 4.9A)
SAH  A 500 (-4.3A)
SAH  A 500 (-3.1A)
SAH  A 500 ( 4.6A)
SAH  A 500 (-3.0A)
SAH  A 500 (-3.8A)
 0.31A 3g2oA-3g2pA:
35.3		 3g2oA-3g2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G2O_A_SAMA500_1
(PCZA361.24)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		3 / 3 ARG A  76
GLU A  92
ASP A 122
 SAH  A 500 (-3.4A)
SAH  A 500 (-2.8A)
SAH  A 500 (-3.6A)
 0.12A 3g2oA-3g2pA:
35.3		 3g2oA-3g2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G2O_B_SAMB600_0
(PCZA361.24)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		12 / 12 GLU A  69
ALA A  71
GLY A  73
LEU A  77
LEU A  91
LEU A  93
ASP A 122
MET A 123
SER A 138
GLY A 140
SER A 141
GLU A 144
 SAH  A 500 (-4.2A)
SAH  A 500 (-3.1A)
SAH  A 500 (-3.2A)
SAH  A 500 (-4.1A)
None
SAH  A 500 (-3.6A)
SAH  A 500 (-3.6A)
SAH  A 500 (-4.3A)
SAH  A 500 (-3.1A)
SAH  A 500 ( 4.6A)
SAH  A 500 (-3.0A)
SAH  A 500 (-3.8A)
 0.49A 3g2oB-3g2pA:
32.3		 3g2oB-3g2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		7 / 12 ALA A  71
GLY A  73
LEU A  93
SER A  94
ASP A 122
MET A 123
SER A 141
 SAH  A 500 (-3.1A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.6A)
SAH  A 500 ( 4.9A)
SAH  A 500 (-3.6A)
SAH  A 500 (-4.3A)
SAH  A 500 (-3.0A)
 0.59A 3pfgA-3g2pA:
18.0		 3pfgA-3g2pA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		4 / 4 THR A 227
ARG A 229
GLU A 210
VAL A  10
 None
 1.00A 4odoC-3g2pA:
undetectable		 4odoC-3g2pA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		5 / 12 PHE A 126
LEU A  70
VAL A  63
THR A  60
PHE A  81
 None
 1.09A 4wnwA-3g2pA:
undetectable		 4wnwA-3g2pA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		5 / 10 LEU A 171
LEU A 169
SER A 124
LEU A 153
LEU A 242
 None
None
SAH  A 500 ( 4.7A)
None
None
 1.18A 4yiaA-3g2pA:
undetectable		 4yiaA-3g2pA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		4 / 6 ARG A  76
PRO A  80
PHE A  81
GLU A  69
 SAH  A 500 (-3.4A)
None
None
SAH  A 500 (-4.2A)
 1.40A 5odqA-3g2pA:
4.0		 5odqA-3g2pA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3g2p PCZA361.24
(Amycolatopsis
orientalis) 		4 / 7 ALA A  71
GLY A  73
GLY A  75
GLU A  92
 SAH  A 500 (-3.1A)
SAH  A 500 (-3.2A)
None
SAH  A 500 (-2.8A)
 0.68A 5ybbB-3g2pA:
9.0		 5ybbB-3g2pA:
21.10