SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		5 / 9 LEU A 184
ASP A 185
LEU A 188
ILE A 221
THR A 285
 None
 1.27A 1hzeA-3g3lA:
undetectable
1hzeB-3g3lA:
undetectable		 1hzeA-3g3lA:
16.34
1hzeB-3g3lA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		5 / 9 THR A 285
LEU A 184
ASP A 185
LEU A 188
ILE A 221
 None
 1.27A 1hzeA-3g3lA:
undetectable
1hzeB-3g3lA:
undetectable		 1hzeA-3g3lA:
16.34
1hzeB-3g3lA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		5 / 10 LEU A 184
ASP A 185
LEU A 188
ILE A 221
THR A 285
 None
 1.27A 1i18A-3g3lA:
undetectable
1i18B-3g3lA:
undetectable		 1i18A-3g3lA:
16.34
1i18B-3g3lA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		5 / 10 THR A 285
LEU A 184
ASP A 185
LEU A 188
ILE A 221
 None
 1.27A 1i18A-3g3lA:
undetectable
1i18B-3g3lA:
undetectable		 1i18A-3g3lA:
16.34
1i18B-3g3lA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		4 / 7 VAL A 322
LEU A 309
THR A 142
VAL A 305
 None
None
None
GOL  A   8 (-3.7A)
 0.78A 1jgsA-3g3lA:
undetectable		 1jgsA-3g3lA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		4 / 6 PRO A 229
MET A 227
ALA A 183
GLU A 180
 None
 1.21A 1qhyA-3g3lA:
undetectable		 1qhyA-3g3lA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		4 / 7 GLU A  60
ALA A  55
ASN A 275
ALA A 122
 None
None
GOL  A  10 (-4.3A)
None
 1.07A 2ejfA-3g3lA:
undetectable		 2ejfA-3g3lA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		4 / 7 GLU A  60
ALA A  55
ASN A 275
ALA A 122
 None
None
GOL  A  10 (-4.3A)
None
 1.14A 2zgwA-3g3lA:
undetectable		 2zgwA-3g3lA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		4 / 6 GLU A  60
ALA A  55
ASN A 275
ALA A 122
 None
None
GOL  A  10 (-4.3A)
None
 1.12A 2zgwB-3g3lA:
undetectable		 2zgwB-3g3lA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		3 / 3 ALA A 255
VAL A 256
GLN A 261
 None
None
GOL  A   6 (-4.2A)
 0.73A 3of4B-3g3lA:
undetectable		 3of4B-3g3lA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2C_A_ACTA153_0
(N UTILIZATION
SUBSTANCE PROTEIN B)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		4 / 4 ASN A 145
GLY A 147
GLU A 148
LYS A 151
 None
 0.94A 3r2cA-3g3lA:
0.2		 3r2cA-3g3lA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		5 / 9 ALA A 122
ILE A  52
GLY A  50
VAL A 119
ASN A 120
 None
 1.23A 4a3uA-3g3lA:
undetectable		 4a3uA-3g3lA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		4 / 8 ILE A 313
ALA A 263
VAL A 242
VAL A 322
 None
None
GOL  A   6 ( 4.9A)
None
 0.78A 4jltA-3g3lA:
undetectable		 4jltA-3g3lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		5 / 12 VAL A 203
PRO A 201
THR A 200
GLU A 198
GLY A 197
 None
 1.31A 4q15B-3g3lA:
undetectable		 4q15B-3g3lA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		5 / 8 LEU A 309
GLY A 320
GLU A 319
GLU A 148
ALA A 149
 None
 1.27A 4rjdA-3g3lA:
undetectable
4rjdB-3g3lA:
undetectable		 4rjdA-3g3lA:
11.84
4rjdB-3g3lA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		4 / 6 VAL A 130
ALA A 128
VAL A 124
TYR A  98
 None
 0.93A 5i8fA-3g3lA:
2.4		 5i8fA-3g3lA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		4 / 8 ILE A 221
ILE A 287
THR A 285
TYR A 284
 None
 1.01A 6cduG-3g3lA:
undetectable
6cduH-3g3lA:
undetectable		 6cduG-3g3lA:
21.41
6cduH-3g3lA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN
(Bacteroides
fragilis) 		5 / 12 VAL A  81
THR A 175
TYR A 232
PRO A 162
VAL A 104
 None
 1.36A 6gngB-3g3lA:
undetectable		 6gngB-3g3lA:
20.36