SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		4 / 5 LEU A 576
LEU A 497
LEU A 528
GLY A 572
 None
 1.01A 1a4lC-3g40A:
undetectable		 1a4lC-3g40A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		4 / 6 MET A 651
GLU A 636
ALA A 748
LEU A 616
 None
 1.18A 1etb1-3g40A:
undetectable		 1etb1-3g40A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		4 / 6 LEU A 760
VAL A 704
VAL A 700
ILE A 635
 None
 0.96A 2hyyA-3g40A:
undetectable		 2hyyA-3g40A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		4 / 6 LEU A 760
VAL A 704
VAL A 700
ILE A 635
 None
 1.00A 2hyyB-3g40A:
undetectable		 2hyyB-3g40A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		4 / 6 LEU A 760
VAL A 704
VAL A 700
ILE A 635
 None
 1.01A 3k5vB-3g40A:
undetectable		 3k5vB-3g40A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		5 / 12 ALA A 667
LYS A 662
LEU A 661
ALA A 718
ILE A 746
 None
 1.21A 3ut5D-3g40A:
2.0		 3ut5D-3g40A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		5 / 12 LEU A 757
ALA A 695
LEU A 691
ALA A 658
ILE A 635
 None
 1.14A 3ut5D-3g40A:
2.0		 3ut5D-3g40A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		4 / 6 ILE A 544
GLN A 540
ILE A 559
ASP A 533
 None
 1.02A 4w5tA-3g40A:
3.8		 4w5tA-3g40A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		5 / 12 LEU A 757
ALA A 695
LEU A 691
ALA A 658
ILE A 635
 None
 1.02A 4x20B-3g40A:
undetectable		 4x20B-3g40A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		3 / 3 LEU A 616
PHE A 587
ILE A 746
 None
 0.67A 5dzk1-3g40A:
undetectable
5dzkF-3g40A:
undetectable
5dzkM-3g40A:
undetectable		 5dzk1-3g40A:
8.33
5dzkF-3g40A:
21.62
5dzkM-3g40A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		4 / 7 LYS A 740
LEU A 715
PRO A 709
LEU A 633
 None
 1.07A 5fxtA-3g40A:
undetectable		 5fxtA-3g40A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		4 / 4 LEU A 661
ARG A 514
ILE A 516
PHE A 512
 None
 0.97A 5kirB-3g40A:
undetectable		 5kirB-3g40A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3g40 NA-K-CL
COTRANSPORTER
(Methanosarcina
acetivorans) 		5 / 12 ILE A 631
ILE A 722
ALA A 748
ILE A 585
ALA A 494
 None
 1.13A 5vceA-3g40A:
undetectable		 5vceA-3g40A:
20.68