SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3g4e REGUCALCIN
(Homo
sapiens) 		4 / 6 SER A 170
ILE A 202
ALA A 125
ALA A 119
 None
 0.79A 1w0gA-3g4eA:
undetectable		 1w0gA-3g4eA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3g4e REGUCALCIN
(Homo
sapiens) 		5 / 12 GLY A 271
LEU A 272
GLY A 279
ALA A 263
ASP A 243
 None
 0.93A 2bm9F-3g4eA:
undetectable		 2bm9F-3g4eA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3g4e REGUCALCIN
(Homo
sapiens) 		5 / 12 GLY A 271
LEU A 272
GLY A 279
ARG A  15
ASP A 243
 None
 0.94A 2bm9F-3g4eA:
undetectable		 2bm9F-3g4eA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3g4e REGUCALCIN
(Homo
sapiens) 		5 / 10 PHE A 114
GLY A 116
PHE A 178
TYR A 167
PHE A 165
 None
 1.35A 3r6wA-3g4eA:
undetectable
3r6wB-3g4eA:
undetectable		 3r6wA-3g4eA:
22.15
3r6wB-3g4eA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3g4e REGUCALCIN
(Homo
sapiens) 		4 / 5 PRO A 229
ASP A 228
ILE A 208
VAL A 289
 None
 1.45A 4hytA-3g4eA:
undetectable		 4hytA-3g4eA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3g4e REGUCALCIN
(Homo
sapiens) 		4 / 6 TYR A 219
GLU A  18
VAL A  61
ALA A  71
 None
CA  A   1 (-2.6A)
None
None
 1.17A 4nkvC-3g4eA:
undetectable		 4nkvC-3g4eA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3g4e REGUCALCIN
(Homo
sapiens) 		4 / 8 LEU A 227
LEU A 214
VAL A 216
ILE A 168
 None
 0.84A 4oj4A-3g4eA:
undetectable		 4oj4A-3g4eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3g4e REGUCALCIN
(Homo
sapiens) 		4 / 8 SER A 192
LEU A 214
VAL A 216
ILE A 168
 None
 0.84A 4oj4A-3g4eA:
undetectable		 4oj4A-3g4eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3g4e REGUCALCIN
(Homo
sapiens) 		4 / 5 GLY A 155
TYR A 173
SER A 170
ASP A 204
 None
None
None
CA  A   1 (-2.9A)
 1.33A 4xueA-3g4eA:
undetectable		 4xueA-3g4eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 3g4e REGUCALCIN
(Homo
sapiens) 		3 / 3 LYS A 163
ASP A 179
ILE A 208
 None
 0.88A 5kc4E-3g4eA:
undetectable		 5kc4E-3g4eA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 3g4e REGUCALCIN
(Homo
sapiens) 		3 / 3 ALA A  79
VAL A 107
TYR A 113
 None
 0.70A 5zmqH-3g4eA:
undetectable		 5zmqH-3g4eA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 3g4e REGUCALCIN
(Homo
sapiens) 		5 / 12 PHE A 102
VAL A  88
ARG A  41
GLY A 105
SER A  60
 None
 1.00A 6c2mA-3g4eA:
undetectable		 6c2mA-3g4eA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 3g4e REGUCALCIN
(Homo
sapiens) 		5 / 12 PHE A 102
VAL A  88
ARG A  41
GLY A 105
SER A  60
 None
 0.98A 6c2mB-3g4eA:
undetectable		 6c2mB-3g4eA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3g4e REGUCALCIN
(Homo
sapiens) 		4 / 8 LYS A 198
GLU A 200
VAL A 216
GLN A 275
 None
 1.18A 6fbvD-3g4eA:
undetectable		 6fbvD-3g4eA:
13.38