SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3g4s 50S RIBOSOMAL
PROTEIN L6P
(Haloarcula
marismortui) 		5 / 12 TRP E  80
GLY E 135
GLY E  75
GLY E  79
ASN E  71
 None
None
None
None
G  02782 ( 3.5A)
 0.88A 2dpmA-3g4sE:
undetectable		 2dpmA-3g4sE:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3g4s 50S RIBOSOMAL
PROTEIN L6P
(Haloarcula
marismortui) 		5 / 12 GLY E  75
GLY E  79
ILE E 138
ARG E  31
GLY E  27
 None
None
U  02781 ( 4.3A)
G  02794 ( 4.5A)
None
 0.86A 2qe6A-3g4sE:
undetectable		 2qe6A-3g4sE:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3g4s 50S RIBOSOMAL
PROTEIN L7AE
(Haloarcula
marismortui) 		4 / 7 VAL F   8
VAL F   4
PHE F  74
GLU F  13
 None
 1.26A 3dqrA-3g4sF:
undetectable
3dqrB-3g4sF:
undetectable		 3dqrA-3g4sF:
18.50
3dqrB-3g4sF:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3g4s 50S RIBOSOMAL
PROTEIN L7AE
(Haloarcula
marismortui) 		5 / 11 THR F  99
ALA F  28
GLY F  27
THR F  26
ALA F  23
 None
 1.14A 3mg0H-3g4sF:
undetectable
3mg0I-3g4sF:
undetectable		 3mg0H-3g4sF:
24.35
3mg0I-3g4sF:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3g4s 50S RIBOSOMAL
PROTEIN L7AE
(Haloarcula
marismortui) 		4 / 7 PHE F  74
GLU F  13
VAL F   8
VAL F   4
 None
 1.28A 3nlqA-3g4sF:
undetectable
3nlqB-3g4sF:
undetectable		 3nlqA-3g4sF:
18.50
3nlqB-3g4sF:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 3g4s 50S RIBOSOMAL
PROTEIN L7AE
(Haloarcula
marismortui) 		5 / 9 ALA F  45
ILE F  75
PRO F  64
ILE F  63
ILE F  40
 None
 1.02A 3s45A-3g4sF:
undetectable		 3s45A-3g4sF:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3g4s 50S RIBOSOMAL
PROTEIN L7AE
(Haloarcula
marismortui) 		3 / 3 PHE F   6
VAL F   4
GLU F  52
 None
 0.79A 4fvqA-3g4sF:
undetectable		 4fvqA-3g4sF:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3g4s 50S RIBOSOMAL
PROTEIN L6P
(Haloarcula
marismortui) 		5 / 12 ILE E 118
THR E 122
VAL E 166
ILE E 148
GLU E 149
 None
 1.31A 4i41A-3g4sE:
undetectable		 4i41A-3g4sE:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3g4s 50S RIBOSOMAL
PROTEIN L6P
(Haloarcula
marismortui) 		3 / 3 ASP E 164
LEU E 108
PHE E  91
 None
None
A  02694 ( 4.5A)
 0.61A 4pthA-3g4sE:
undetectable		 4pthA-3g4sE:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3g4s 50S RIBOSOMAL
PROTEIN L6P
(Haloarcula
marismortui) 		5 / 12 GLY E  44
ASP E  43
PHE E  73
ILE E   7
ALA E  13
 None
 1.41A 4wh5A-3g4sE:
undetectable		 4wh5A-3g4sE:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3g4s 50S RIBOSOMAL
PROTEIN L6P
(Haloarcula
marismortui) 		4 / 6 ARG E  31
ILE E  69
ILE E 138
ASP E 137
 G  02794 ( 4.5A)
None
U  02781 ( 4.3A)
None
 1.18A 4z4cA-3g4sE:
1.9		 4z4cA-3g4sE:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3g4s 50S RIBOSOMAL
PROTEIN L6P
(Haloarcula
marismortui) 		4 / 6 ASP E  25
GLY E  24
ASP E  12
ASP E  10
 None
 1.28A 5hp1A-3g4sE:
5.1		 5hp1A-3g4sE:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3g4s 50S RIBOSOMAL
PROTEIN L6P
(Haloarcula
marismortui) 		3 / 3 THR E  61
PRO E   1
ARG E   2
 A  02792 ( 3.9A)
None
None
 0.87A 5nd7B-3g4sE:
undetectable		 5nd7B-3g4sE:
18.44