SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		4 / 6 THR A 651
PHE A 682
GLU A 685
GLY A 684
 None
 1.14A 1kqbA-3g5bA:
undetectable
1kqbB-3g5bA:
undetectable		 1kqbA-3g5bA:
20.19
1kqbB-3g5bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		4 / 6 THR A 651
PHE A 682
GLU A 685
GLY A 684
 None
 1.15A 1kqbC-3g5bA:
undetectable
1kqbD-3g5bA:
undetectable		 1kqbC-3g5bA:
20.19
1kqbD-3g5bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		4 / 7 GLU A 740
VAL A 739
TYR A 710
LEU A 758
 None
 0.95A 3qeoB-3g5bA:
undetectable		 3qeoB-3g5bA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		3 / 3 LYS A 743
PRO A 744
LEU A 745
 None
 0.81A 3tpxE-3g5bA:
undetectable		 3tpxE-3g5bA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		4 / 6 LEU A 796
LEU A 712
ILE A 699
THR A 826
 None
 0.98A 4do3B-3g5bA:
undetectable		 4do3B-3g5bA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		5 / 12 LEU A 907
GLU A 911
GLY A 570
LEU A 565
ARG A 555
 None
 1.22A 4retA-3g5bA:
undetectable		 4retA-3g5bA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		5 / 12 LEU A 907
GLU A 911
GLY A 570
LEU A 565
ARG A 555
 None
 1.21A 4retC-3g5bA:
undetectable		 4retC-3g5bA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		3 / 3 ARG A 881
ASP A 879
TRP A 880
 None
 1.03A 4xdqA-3g5bA:
undetectable		 4xdqA-3g5bA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		5 / 12 ALA A 691
TRP A 783
LEU A 746
HIS A 624
LEU A 601
 None
 1.31A 4xi3D-3g5bA:
undetectable		 4xi3D-3g5bA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		3 / 3 CYH A 808
LYS A 809
HIS A 759
 None
 1.24A 5js5A-3g5bA:
undetectable		 5js5A-3g5bA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		3 / 3 VAL A 619
ARG A 881
PRO A 902
 None
 0.76A 5koxA-3g5bA:
undetectable		 5koxA-3g5bA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3g5b NETRIN RECEPTOR
UNC5B
(Rattus
norvegicus) 		3 / 3 GLU A 776
ARG A 755
TYR A 774
 None
 0.61A 5trqB-3g5bA:
undetectable		 5trqB-3g5bA:
22.50