SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		4 / 8 GLU A 114
ALA A 109
ALA A  64
THR A  34
 None
 0.83A 1ie4B-3g5iA:
undetectable
1ie4D-3g5iA:
undetectable		 1ie4B-3g5iA:
19.00
1ie4D-3g5iA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 LEU A   7
THR A 124
THR A 244
ILE A 147
VAL A 148
 None
CA  A 501 ( 4.9A)
None
None
None
 0.99A 1pkvA-3g5iA:
undetectable
1pkvB-3g5iA:
undetectable		 1pkvA-3g5iA:
19.22
1pkvB-3g5iA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 THR A  34
THR A 124
THR A 244
ILE A 147
VAL A 148
 None
CA  A 501 ( 4.9A)
None
None
None
 1.10A 1pkvA-3g5iA:
undetectable
1pkvB-3g5iA:
undetectable		 1pkvA-3g5iA:
19.22
1pkvB-3g5iA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		4 / 7 LYS A  69
ALA A  67
LEU A 132
ALA A 173
 None
 1.07A 1sn0B-3g5iA:
undetectable
1sn0D-3g5iA:
undetectable		 1sn0B-3g5iA:
23.60
1sn0D-3g5iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 ILE A  77
GLY A  38
ASP A 241
PHE A 165
ASP A  14
 None
None
DNB  A 502 ( 2.5A)
DNB  A 502 ( 4.3A)
DNB  A 502 (-2.9A)
 1.07A 1zz1C-3g5iA:
2.4		 1zz1C-3g5iA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 GLY A 298
GLN A 297
LEU A 239
CYH A 243
PHE A 254
 None
 1.30A 3cldA-3g5iA:
0.0		 3cldA-3g5iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_1
(GLUCOCORTICOID
RECEPTOR)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 GLY A 298
GLN A 297
LEU A 239
CYH A 243
PHE A 254
 None
 1.30A 3cldB-3g5iA:
undetectable		 3cldB-3g5iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 10 LEU A  56
ARG A  51
PRO A 242
GLY A  12
PRO A  11
 None
 1.40A 3hcoB-3g5iA:
3.0		 3hcoB-3g5iA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 GLY A 298
GLN A 297
LEU A 239
CYH A 243
PHE A 254
 None
 1.29A 3mnoA-3g5iA:
undetectable		 3mnoA-3g5iA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 GLY A 298
GLN A 297
LEU A 239
CYH A 243
PHE A 254
 None
 1.24A 3mnpA-3g5iA:
undetectable		 3mnpA-3g5iA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 10 ALA A 195
VAL A 300
ILE A 197
GLY A 236
VAL A 235
 None
 1.05A 3oxvB-3g5iA:
undetectable		 3oxvB-3g5iA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 ASP A 241
PRO A  11
ILE A 167
MET A 150
ASP A  10
 DNB  A 502 ( 2.5A)
None
None
DNB  A 502 (-3.4A)
CA  A 501 (-3.0A)
 1.37A 3topA-3g5iA:
undetectable		 3topA-3g5iA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		4 / 5 LEU A 134
LEU A 133
LEU A 140
SER A 142
 None
 1.00A 3vhuA-3g5iA:
undetectable		 3vhuA-3g5iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 VAL A 276
ALA A 153
ASP A 190
SER A 256
VAL A 261
 None
 1.35A 4eilA-3g5iA:
undetectable		 4eilA-3g5iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 10 VAL A 276
ALA A 153
ASP A 190
SER A 256
VAL A 261
 None
 1.41A 4eilB-3g5iA:
undetectable		 4eilB-3g5iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		4 / 5 PRO A  11
ASP A  10
ILE A  33
VAL A 122
 None
CA  A 501 (-3.0A)
None
None
 1.34A 4hytA-3g5iA:
5.0		 4hytA-3g5iA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 LEU A  21
LEU A  28
ILE A  33
ILE A  61
LEU A  56
 None
 1.09A 4j24A-3g5iA:
undetectable		 4j24A-3g5iA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 LEU A  21
LEU A  28
ILE A  33
ILE A  61
LEU A  56
 None
 1.09A 4j24C-3g5iA:
undetectable		 4j24C-3g5iA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 LEU A  21
LEU A  28
ILE A  33
ILE A  61
LEU A  56
 None
 1.11A 4j26B-3g5iA:
undetectable		 4j26B-3g5iA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 VAL A 276
ALA A 153
ASP A 190
SER A 256
VAL A 261
 None
 1.37A 4kyaG-3g5iA:
2.2		 4kyaG-3g5iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		3 / 3 ILE A 176
MET A  72
ARG A  73
 None
 0.80A 4lnwA-3g5iA:
undetectable		 4lnwA-3g5iA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		3 / 3 ILE A 176
MET A  72
ARG A  73
 None
 0.81A 4lnxA-3g5iA:
undetectable		 4lnxA-3g5iA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 ASN A 166
LEU A  87
GLY A  12
ASP A  14
THR A  45
 DNB  A 502 (-3.4A)
None
None
DNB  A 502 (-2.9A)
None
 1.17A 4o5fA-3g5iA:
undetectable
4o5fB-3g5iA:
undetectable		 4o5fA-3g5iA:
24.17
4o5fB-3g5iA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 THR A  45
ASN A 166
LEU A  87
GLY A  12
ASP A  14
 None
DNB  A 502 (-3.4A)
None
None
DNB  A 502 (-2.9A)
 1.19A 4o5fA-3g5iA:
undetectable
4o5fB-3g5iA:
undetectable		 4o5fA-3g5iA:
24.17
4o5fB-3g5iA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 ALA A 153
GLY A 188
ILE A 167
ASN A 166
MET A 150
 None
None
None
DNB  A 502 (-3.4A)
DNB  A 502 (-3.4A)
 1.30A 4obwD-3g5iA:
undetectable		 4obwD-3g5iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		4 / 8 LEU A   6
LEU A 140
HIS A 141
ILE A 176
 None
 1.06A 4ok1A-3g5iA:
undetectable		 4ok1A-3g5iA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 ALA A 174
ALA A 173
GLY A 152
GLY A 151
SER A 123
 None
 1.02A 4qvlK-3g5iA:
undetectable
4qvlL-3g5iA:
undetectable		 4qvlK-3g5iA:
23.78
4qvlL-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 ALA A 174
ALA A 173
GLY A 152
GLY A 151
SER A 123
 None
 1.01A 4qvlY-3g5iA:
undetectable
4qvlZ-3g5iA:
undetectable		 4qvlY-3g5iA:
23.78
4qvlZ-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 10 ALA A 174
ALA A 173
GLY A 152
GLY A 151
SER A 123
 None
 1.01A 4qvmY-3g5iA:
undetectable
4qvmZ-3g5iA:
undetectable		 4qvmY-3g5iA:
23.78
4qvmZ-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 ALA A 174
ALA A 173
GLY A 152
GLY A 151
SER A 123
 None
 1.00A 4qvwK-3g5iA:
undetectable
4qvwL-3g5iA:
undetectable		 4qvwK-3g5iA:
23.45
4qvwL-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 THR A 274
ALA A 174
ALA A 173
GLY A 151
SER A 123
 None
 1.09A 4qvwK-3g5iA:
undetectable
4qvwL-3g5iA:
undetectable		 4qvwK-3g5iA:
23.45
4qvwL-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 ALA A 174
ALA A 173
GLY A 152
GLY A 151
SER A 123
 None
 1.00A 4qvwY-3g5iA:
undetectable
4qvwZ-3g5iA:
undetectable		 4qvwY-3g5iA:
23.45
4qvwZ-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 THR A 274
ALA A 174
ALA A 173
GLY A 151
SER A 123
 None
 1.09A 4qvwY-3g5iA:
undetectable
4qvwZ-3g5iA:
undetectable		 4qvwY-3g5iA:
23.45
4qvwZ-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 ALA A 174
ALA A 173
GLY A 152
GLY A 151
SER A 123
 None
 0.98A 4qw1K-3g5iA:
undetectable
4qw1L-3g5iA:
undetectable		 4qw1K-3g5iA:
23.78
4qw1L-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 9 THR A 274
ALA A 174
ALA A 173
GLY A 152
GLY A 151
 None
 1.16A 4qwuK-3g5iA:
undetectable
4qwuL-3g5iA:
undetectable		 4qwuK-3g5iA:
23.78
4qwuL-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 9 THR A 274
ALA A 174
ALA A 173
GLY A 152
GLY A 151
 None
 1.11A 4qwuY-3g5iA:
undetectable
4qwuZ-3g5iA:
undetectable		 4qwuY-3g5iA:
23.78
4qwuZ-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 ASP A  14
LEU A 239
LEU A 303
SER A  25
ILE A  17
 DNB  A 502 (-2.9A)
None
None
None
None
 1.07A 4x1fA-3g5iA:
undetectable		 4x1fA-3g5iA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 ASP A  14
LEU A 239
LEU A 303
SER A  25
ILE A  17
 DNB  A 502 (-2.9A)
None
None
None
None
 1.06A 4x1gA-3g5iA:
undetectable		 4x1gA-3g5iA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 LEU A  53
LEU A   7
ALA A  22
VAL A  20
ILE A 245
 None
 1.14A 4x1yB-3g5iA:
7.0		 4x1yB-3g5iA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 ASN A 166
LEU A  87
GLY A  12
ASP A  14
THR A  45
 DNB  A 502 (-3.4A)
None
None
DNB  A 502 (-2.9A)
None
 1.17A 5b8hA-3g5iA:
undetectable
5b8hB-3g5iA:
undetectable		 5b8hA-3g5iA:
21.88
5b8hB-3g5iA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 THR A  45
ASN A 166
LEU A  87
GLY A  12
ASP A  14
 None
DNB  A 502 (-3.4A)
None
None
DNB  A 502 (-2.9A)
 1.20A 5b8hA-3g5iA:
undetectable
5b8hB-3g5iA:
undetectable		 5b8hA-3g5iA:
21.88
5b8hB-3g5iA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 ALA A 174
ALA A 173
GLY A 152
GLY A 151
SER A 123
 None
 1.02A 5bxnK-3g5iA:
undetectable
5bxnL-3g5iA:
undetectable		 5bxnK-3g5iA:
23.78
5bxnL-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 11 ALA A 174
ALA A 173
GLY A 152
GLY A 151
SER A 123
 None
 1.02A 5bxnY-3g5iA:
undetectable
5bxnZ-3g5iA:
undetectable		 5bxnY-3g5iA:
23.78
5bxnZ-3g5iA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Escherichia
coli) 		5 / 12 VAL A 294
PHE A 299
PHE A 254
GLN A 127
ILE A  19
 None
 1.36A 6becA-3g5iA:
undetectable
6becB-3g5iA:
undetectable
6becC-3g5iA:
undetectable		 6becA-3g5iA:
20.00
6becB-3g5iA:
20.00
6becC-3g5iA:
20.00