SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		4 / 6 VAL A  18
MET A  37
VAL A 112
ILE A 103
 None
 0.96A 1e06A-3g5jA:
undetectable		 1e06A-3g5jA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		4 / 6 TYR A 124
VAL A 114
VAL A  15
ILE A   4
 None
 0.92A 3pyyA-3g5jA:
undetectable		 3pyyA-3g5jA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		4 / 7 ILE A  75
PHE A  40
LYS A  63
GLY A  64
 None
None
None
PGE  A 302 ( 4.0A)
 1.13A 3sj0X-3g5jA:
undetectable		 3sj0X-3g5jA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 11 SER A 102
ILE A 103
LEU A  82
ASP A  19
TYR A  26
 PGE  A 302 ( 3.9A)
None
None
None
None
 1.06A 4fogA-3g5jA:
undetectable		 4fogA-3g5jA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 11 SER A 102
ILE A 103
LEU A  82
ASP A  19
TYR A  26
 PGE  A 302 ( 3.9A)
None
None
None
None
 1.09A 4fogC-3g5jA:
undetectable		 4fogC-3g5jA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 12 SER A 102
ILE A 103
LEU A  82
ASP A  19
TYR A  26
 PGE  A 302 ( 3.9A)
None
None
None
None
 1.09A 4foxB-3g5jA:
undetectable		 4foxB-3g5jA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 12 SER A 102
ILE A 103
LEU A  82
ASP A  19
TYR A  26
 PGE  A 302 ( 3.9A)
None
None
None
None
 1.15A 4foxG-3g5jA:
undetectable		 4foxG-3g5jA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 12 GLY A 119
TYR A  52
ILE A  51
PHE A  40
GLY A  64
 None
None
None
None
PGE  A 302 ( 4.0A)
 0.98A 4ze2A-3g5jA:
undetectable		 4ze2A-3g5jA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		3 / 3 VAL A  68
HIS A  45
VAL A  48
 None
GOL  A 303 (-3.5A)
None
 0.71A 5jmnC-3g5jA:
undetectable		 5jmnC-3g5jA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 10 ALA A  83
LEU A  82
VAL A  18
ILE A 103
LEU A 107
 None
 1.45A 6h1lA-3g5jA:
undetectable		 6h1lA-3g5jA:
13.57