SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 5 GLY A 354
LEU A  20
THR A  19
VAL A 130
 None
 1.06A 1ekjF-3g5sA:
undetectable
1ekjG-3g5sA:
undetectable		 1ekjF-3g5sA:
19.51
1ekjG-3g5sA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 GLY A 354
LEU A 313
LEU A 131
ALA A 132
LEU A 319
 None
 1.11A 1jipA-3g5sA:
undetectable		 1jipA-3g5sA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 8 LEU A  66
VAL A 400
GLY A 377
GLU A  70
 None
 0.82A 1jlfA-3g5sA:
undetectable
1jlfB-3g5sA:
undetectable		 1jlfA-3g5sA:
21.75
1jlfB-3g5sA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 11 LEU A 362
LEU A  20
ALA A 132
VAL A  25
TYR A 332
 None
 1.37A 1kt6A-3g5sA:
undetectable		 1kt6A-3g5sA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 LEU A 375
GLY A 354
ASN A 356
ALA A 353
ALA A 333
 None
 1.16A 2bm9C-3g5sA:
undetectable		 2bm9C-3g5sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 LEU A 141
GLU A  31
GLY A   8
ALA A 132
ALA A 334
 FAD  A 444 ( 4.0A)
FAD  A 444 (-2.7A)
FAD  A 444 (-3.3A)
None
None
 0.96A 2br4A-3g5sA:
undetectable		 2br4A-3g5sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 LEU A 141
GLU A  31
GLY A   8
ALA A 132
ALA A 334
 FAD  A 444 ( 4.0A)
FAD  A 444 (-2.7A)
FAD  A 444 (-3.3A)
None
None
 1.00A 2br4D-3g5sA:
undetectable		 2br4D-3g5sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 LEU A 141
GLU A  31
GLY A   8
ALA A 132
ALA A 334
 FAD  A 444 ( 4.0A)
FAD  A 444 (-2.7A)
FAD  A 444 (-3.3A)
None
None
 1.05A 2br4F-3g5sA:
undetectable		 2br4F-3g5sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 ALA A  12
ALA A  47
ALA A 348
GLY A 342
GLY A 335
 FAD  A 444 (-3.4A)
None
None
FAD  A 444 (-3.1A)
FAD  A 444 (-3.3A)
 1.11A 2igtA-3g5sA:
undetectable		 2igtA-3g5sA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 ALA A  12
ALA A  47
ALA A 348
GLY A 342
GLY A 335
 FAD  A 444 (-3.4A)
None
None
FAD  A 444 (-3.1A)
FAD  A 444 (-3.3A)
 1.14A 2igtB-3g5sA:
2.6		 2igtB-3g5sA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 9 MET A  79
SER A  76
TRP A  18
ALA A  12
LEU A  11
 None
None
None
FAD  A 444 (-3.4A)
FAD  A 444 (-4.2A)
 1.38A 2o01B-3g5sA:
undetectable		 2o01B-3g5sA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 VAL A 226
CYH A 223
THR A 279
ASP A 158
GLN A 391
 None
GSH  A 445 (-2.5A)
None
None
MG  A 446 ( 2.7A)
 1.21A 3a35B-3g5sA:
undetectable		 3a35B-3g5sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 8 VAL A 340
THR A 349
GLY A  13
ALA A  12
 None
None
None
FAD  A 444 (-3.4A)
 0.75A 3aruA-3g5sA:
undetectable		 3aruA-3g5sA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 LEU A 399
PRO A 401
GLY A 420
GLY A 376
GLY A 377
 None
 1.02A 3axzA-3g5sA:
undetectable		 3axzA-3g5sA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		3 / 3 LEU A 113
VAL A   6
ARG A   3
 None
 0.72A 3b0wB-3g5sA:
undetectable		 3b0wB-3g5sA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 VAL A 226
CYH A 223
THR A 279
ASP A 158
GLN A 391
 None
GSH  A 445 (-2.5A)
None
None
MG  A 446 ( 2.7A)
 1.13A 3ddyA-3g5sA:
undetectable		 3ddyA-3g5sA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 ALA A 348
VAL A 130
VAL A   6
LEU A  20
THR A  19
 None
 1.09A 3hkuA-3g5sA:
undetectable		 3hkuA-3g5sA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 LEU A  66
GLY A 377
GLY A 376
PRO A 369
ALA A 395
 None
 1.20A 3i5uA-3g5sA:
undetectable		 3i5uA-3g5sA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.84A 3x2qC-3g5sA:
undetectable
3x2qJ-3g5sA:
undetectable		 3x2qC-3g5sA:
20.48
3x2qJ-3g5sA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 LEU A 375
GLY A 335
GLY A 134
LEU A 352
GLY A 354
 None
FAD  A 444 (-3.3A)
FAD  A 444 (-3.2A)
None
None
 0.85A 4blvA-3g5sA:
undetectable		 4blvA-3g5sA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		3 / 3 LEU A  11
GLU A  15
SER A 346
 FAD  A 444 (-4.2A)
None
FAD  A 444 (-3.3A)
 0.76A 4ccqA-3g5sA:
undetectable		 4ccqA-3g5sA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 ARG A  22
PRO A 369
SER A 373
TRP A 427
 None
 1.46A 4kmmA-3g5sA:
undetectable		 4kmmA-3g5sA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 VAL A  50
ALA A  40
THR A  38
GLY A 134
GLY A   8
 None
FAD  A 444 ( 4.1A)
FAD  A 444 (-4.5A)
FAD  A 444 (-3.2A)
FAD  A 444 (-3.3A)
 0.67A 4rzvB-3g5sA:
undetectable		 4rzvB-3g5sA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 9 MET A  79
SER A  76
TRP A  18
ALA A  12
LEU A  11
 None
None
None
FAD  A 444 (-3.4A)
FAD  A 444 (-4.2A)
 1.19A 4y28B-3g5sA:
0.2		 4y28B-3g5sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 LEU A 399
PRO A 401
GLY A 420
GLY A 376
GLY A 377
 None
 1.00A 4yvgA-3g5sA:
undetectable		 4yvgA-3g5sA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 VAL A  78
LEU A  11
SER A 346
GLU A 345
 None
FAD  A 444 (-4.2A)
FAD  A 444 (-3.3A)
None
 0.99A 4zphA-3g5sA:
undetectable
4zphB-3g5sA:
undetectable		 4zphA-3g5sA:
22.57
4zphB-3g5sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.89A 5b1aC-3g5sA:
undetectable
5b1aJ-3g5sA:
undetectable		 5b1aC-3g5sA:
20.48
5b1aJ-3g5sA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.87A 5b1aP-3g5sA:
undetectable
5b1aW-3g5sA:
undetectable		 5b1aP-3g5sA:
20.48
5b1aW-3g5sA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.87A 5b3sC-3g5sA:
undetectable
5b3sJ-3g5sA:
undetectable		 5b3sC-3g5sA:
20.48
5b3sJ-3g5sA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.88A 5b3sP-3g5sA:
undetectable		 5b3sP-3g5sA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 4 TYR A 103
GLY A  75
SER A  76
LEU A  77
 None
 1.46A 5bphC-3g5sA:
2.0		 5bphC-3g5sA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 11 THR A  19
SER A  76
GLY A 350
THR A 349
ALA A 348
 None
 1.22A 5bxnH-3g5sA:
undetectable
5bxnI-3g5sA:
undetectable		 5bxnH-3g5sA:
19.73
5bxnI-3g5sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 11 THR A  19
SER A  76
GLY A 350
THR A 349
ALA A 348
 None
 1.22A 5bxnV-3g5sA:
undetectable
5bxnW-3g5sA:
undetectable		 5bxnV-3g5sA:
19.73
5bxnW-3g5sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 9 ALA A 395
LEU A  66
GLY A  65
LEU A  67
LEU A 378
 None
 1.06A 5dqfA-3g5sA:
undetectable		 5dqfA-3g5sA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 6 PHE A  30
ARG A  28
GLU A 115
GLU A   2
 None
 1.38A 5h4dA-3g5sA:
1.7		 5h4dA-3g5sA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 PRO A  39
ALA A  40
VAL A  50
LEU A  11
SER A  14
 None
FAD  A 444 ( 4.1A)
None
FAD  A 444 (-4.2A)
None
 1.19A 5hv1A-3g5sA:
undetectable		 5hv1A-3g5sA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.94A 5iy5C-3g5sA:
undetectable
5iy5J-3g5sA:
undetectable		 5iy5C-3g5sA:
20.35
5iy5J-3g5sA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 LEU A  11
ALA A   9
GLY A 335
THR A 137
LEU A 108
 FAD  A 444 (-4.2A)
None
FAD  A 444 (-3.3A)
FAD  A 444 ( 4.8A)
None
 0.99A 5nfjA-3g5sA:
2.3		 5nfjA-3g5sA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 8 LEU A  20
ALA A 132
VAL A  25
TYR A 332
 None
 0.89A 5nu7A-3g5sA:
undetectable		 5nu7A-3g5sA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 MET A  79
SER A  76
TRP A  18
ALA A  12
LEU A  11
 None
None
None
FAD  A 444 (-3.4A)
FAD  A 444 (-4.2A)
 1.22A 5oy02-3g5sA:
undetectable		 5oy02-3g5sA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 8 GLN A 391
MET A 393
TYR A 381
MET A 271
 MG  A 446 ( 2.7A)
None
None
None
 1.48A 5wqpA-3g5sA:
4.1		 5wqpA-3g5sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 ALA A 353
VAL A   6
GLY A  10
ALA A  47
LEU A  55
 None
None
FAD  A 444 (-3.1A)
None
None
 1.38A 5x23A-3g5sA:
undetectable		 5x23A-3g5sA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 LEU A 337
GLY A 134
ALA A 333
GLY A 339
LEU A 154
 None
FAD  A 444 (-3.2A)
None
None
None
 0.98A 5xv7A-3g5sA:
undetectable		 5xv7A-3g5sA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.87A 5z84C-3g5sA:
undetectable
5z84J-3g5sA:
undetectable		 5z84C-3g5sA:
20.48
5z84J-3g5sA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.87A 5z85C-3g5sA:
undetectable
5z85J-3g5sA:
undetectable		 5z85C-3g5sA:
20.48
5z85J-3g5sA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.88A 5zcoC-3g5sA:
undetectable
5zcoJ-3g5sA:
undetectable		 5zcoC-3g5sA:
20.48
5zcoJ-3g5sA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		4 / 7 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.85A 5zcqP-3g5sA:
undetectable
5zcqW-3g5sA:
undetectable		 5zcqP-3g5sA:
20.48
5zcqW-3g5sA:
9.02