SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  21
GLY A  48
THR A  49
ALA A  50
 SAH  A 308 (-4.6A)
None
SAH  A 308 (-3.4A)
SAH  A 308 ( 4.6A)
 0.86A 2a1hA-3g5tA:
undetectable
2a1hB-3g5tA:
undetectable		 2a1hA-3g5tA:
20.80
2a1hB-3g5tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 TYR A  21
GLY A  44
GLY A  48
THR A  49
ALA A  50
 SAH  A 308 (-4.6A)
SAH  A 308 (-3.6A)
None
SAH  A 308 (-3.4A)
SAH  A 308 ( 4.6A)
 0.81A 2ej3B-3g5tA:
undetectable		 2ej3B-3g5tA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 7 TYR A  14
GLY A  46
THR A  49
TYR A  21
ASP A  68
 SAH  A 308 ( 4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-3.4A)
SAH  A 308 (-4.6A)
SAH  A 308 (-2.6A)
 0.89A 2g70A-3g5tA:
12.6		 2g70A-3g5tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 7 TYR A  14
GLY A  46
THR A  49
TYR A  21
ASP A  68
 SAH  A 308 ( 4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-3.4A)
SAH  A 308 (-4.6A)
SAH  A 308 (-2.6A)
 0.95A 2g70B-3g5tA:
12.5		 2g70B-3g5tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A  14
GLY A  46
TYR A  21
ASP A  68
 SAH  A 308 ( 4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.6A)
SAH  A 308 (-2.6A)
 0.78A 2g72A-3g5tA:
12.8		 2g72A-3g5tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A  14
GLY A  46
TYR A  21
ASP A  68
 SAH  A 308 ( 4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.6A)
SAH  A 308 (-2.6A)
 0.82A 2g72B-3g5tA:
12.7		 2g72B-3g5tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A  87
SER A  84
PHE A  93
 None
 0.76A 3d4sA-3g5tA:
undetectable		 3d4sA-3g5tA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A   4
TYR A  21
GLY A  44
GLY A  46
SER A  70
 SAH  A 308 ( 4.3A)
SAH  A 308 (-4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.8A)
 1.32A 3dlcA-3g5tA:
15.2		 3dlcA-3g5tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 143
ILE A 145
ALA A 135
ASP A 115
GLN A 112
 None
 1.22A 3nmuB-3g5tA:
undetectable
3nmuJ-3g5tA:
9.9		 3nmuB-3g5tA:
21.05
3nmuJ-3g5tA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  14
GLY A  46
ASP A  68
 SAH  A 308 ( 4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-2.6A)
 0.26A 3ou6C-3g5tA:
12.8		 3ou6C-3g5tA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A  41
PHE A 126
GLY A  46
TYR A  14
ILE A  74
 None
SAH  A 308 (-4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 ( 4.6A)
None
 1.43A 3owxA-3g5tA:
undetectable
3owxB-3g5tA:
undetectable		 3owxA-3g5tA:
23.10
3owxB-3g5tA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  44
GLY A  46
ASP A  68
SER A  97
GLU A 121
 SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-2.6A)
SAH  A 308 (-3.7A)
T8N  A 309 ( 4.4A)
 1.27A 3t7sA-3g5tA:
15.1		 3t7sA-3g5tA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  44
GLY A  46
ASP A  68
SER A  97
GLU A 121
 SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-2.6A)
SAH  A 308 (-3.7A)
T8N  A 309 ( 4.4A)
 1.34A 3t7sB-3g5tA:
15.5		 3t7sB-3g5tA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  44
GLY A  46
ASP A  68
SER A  97
GLU A 121
 SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-2.6A)
SAH  A 308 (-3.7A)
T8N  A 309 ( 4.4A)
 1.35A 3t7sD-3g5tA:
15.4		 3t7sD-3g5tA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 TRP A 246
TRP A 179
TYR A 170
TYR A 242
 EDO  A 301 ( 4.1A)
None
None
T8N  A 309 ( 4.2A)
 1.50A 4a3uA-3g5tA:
undetectable		 4a3uA-3g5tA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 184
THR A 245
TRP A 246
 T8N  A 309 ( 2.9A)
None
EDO  A 301 ( 4.1A)
 0.99A 4d7hA-3g5tA:
undetectable		 4d7hA-3g5tA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  44
GLY A  46
LEU A  69
SER A  70
TRP A 125
 SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.1A)
SAH  A 308 (-4.8A)
T8N  A 309 (-3.9A)
 0.56A 4htfA-3g5tA:
14.0		 4htfA-3g5tA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  44
GLY A  46
LEU A  69
SER A  70
TRP A 125
 SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.1A)
SAH  A 308 (-4.8A)
T8N  A 309 (-3.9A)
 0.51A 4htfB-3g5tA:
14.1		 4htfB-3g5tA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  44
GLY A  46
LEU A  69
SER A  70
CYH A 122
 SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.1A)
SAH  A 308 (-4.8A)
SAH  A 308 (-4.8A)
 0.95A 4krhA-3g5tA:
14.9		 4krhA-3g5tA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  44
GLY A  46
LEU A  69
SER A  70
CYH A 122
 SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.1A)
SAH  A 308 (-4.8A)
SAH  A 308 (-4.8A)
 0.92A 4krhB-3g5tA:
15.0		 4krhB-3g5tA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A   4
GLY A  44
GLY A  46
SER A  70
MET A  73
 SAH  A 308 ( 4.3A)
SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.8A)
SAH  A 308 (-4.4A)
 0.58A 4qdjA-3g5tA:
12.9		 4qdjA-3g5tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR A  26
ASP A  42
ASP A  68
TYR A  14
 None
SAH  A 308 ( 4.9A)
SAH  A 308 (-2.6A)
SAH  A 308 ( 4.6A)
 1.41A 4qdjA-3g5tA:
12.8		 4qdjA-3g5tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  14
GLY A  44
GLY A  46
MET A  73
TRP A 125
 SAH  A 308 ( 4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.4A)
T8N  A 309 (-3.9A)
 0.89A 4qtuD-3g5tA:
13.9		 4qtuD-3g5tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  14
GLY A  44
GLY A  46
SER A  70
MET A  73
 SAH  A 308 ( 4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.8A)
SAH  A 308 (-4.4A)
 0.40A 4qtuD-3g5tA:
13.9		 4qtuD-3g5tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 184
THR A 245
TRP A 246
 T8N  A 309 ( 2.9A)
None
EDO  A 301 ( 4.1A)
 0.99A 4uglA-3g5tA:
undetectable		 4uglA-3g5tA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 266
TYR A 249
ASP A 263
TYR A 242
 None
None
EDO  A 300 (-4.8A)
T8N  A 309 ( 4.2A)
 0.92A 5cfsA-3g5tA:
undetectable		 5cfsA-3g5tA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  21
GLY A  44
LEU A  69
SER A  70
SER A  97
 SAH  A 308 (-4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.1A)
SAH  A 308 (-4.8A)
SAH  A 308 (-3.7A)
 0.79A 5dpdA-3g5tA:
10.8		 5dpdA-3g5tA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A  21
GLY A  44
ASP A  68
LEU A  69
SER A  70
SER A  97
 SAH  A 308 (-4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-2.6A)
SAH  A 308 (-4.1A)
SAH  A 308 (-4.8A)
SAH  A 308 (-3.7A)
 0.85A 5dpdB-3g5tA:
10.9		 5dpdB-3g5tA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  44
SER A  67
GLY A  66
ALA A 119
 SAH  A 308 (-3.6A)
None
None
None
 0.85A 5e26A-3g5tA:
undetectable
5e26B-3g5tA:
undetectable		 5e26A-3g5tA:
22.76
5e26B-3g5tA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 119
GLY A  44
SER A  67
GLY A  66
 None
SAH  A 308 (-3.6A)
None
None
 0.88A 5e26A-3g5tA:
undetectable
5e26B-3g5tA:
undetectable		 5e26A-3g5tA:
22.76
5e26B-3g5tA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  44
SER A  67
GLY A  66
ALA A 119
 SAH  A 308 (-3.6A)
None
None
None
 0.87A 5e26C-3g5tA:
undetectable
5e26D-3g5tA:
undetectable		 5e26C-3g5tA:
22.76
5e26D-3g5tA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 184
THR A 245
TRP A 246
 T8N  A 309 ( 2.9A)
None
EDO  A 301 ( 4.1A)
 1.01A 5g6cA-3g5tA:
undetectable		 5g6cA-3g5tA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 101
CYH A  45
THR A  51
PHE A  93
 None
 1.12A 5mwyA-3g5tA:
undetectable		 5mwyA-3g5tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 TRP A 148
TYR A  21
VAL A  43
ASP A 127
PHE A 126
 None
SAH  A 308 (-4.6A)
None
None
SAH  A 308 (-4.6A)
 1.36A 5vlmC-3g5tA:
undetectable		 5vlmC-3g5tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 147
TRP A 148
TYR A  21
VAL A  43
 None
None
SAH  A 308 (-4.6A)
None
 0.96A 5vlmF-3g5tA:
undetectable		 5vlmF-3g5tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  58
TYR A  26
LEU A 228
ALA A 146
LEU A 295
 None
 1.15A 5y7pB-3g5tA:
undetectable		 5y7pB-3g5tA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  58
TYR A  26
LEU A 228
ALA A 146
LEU A 295
 None
 1.19A 5y7pD-3g5tA:
undetectable		 5y7pD-3g5tA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  58
TYR A  26
LEU A 228
ALA A 146
LEU A 295
 None
 1.16A 5y7pH-3g5tA:
undetectable		 5y7pH-3g5tA:
23.46