SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g64'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3g64 PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
coelicolor) 		4 / 7 PHE A  72
PHE A  96
ILE A  82
GLY A 126
 None
 1.00A 2v0mC-3g64A:
undetectable		 2v0mC-3g64A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3g64 PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
coelicolor) 		4 / 7 LEU A  54
VAL A  60
VAL A  19
LEU A 214
 None
 0.93A 3rgfA-3g64A:
undetectable		 3rgfA-3g64A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3g64 PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
coelicolor) 		3 / 3 THR A  22
VAL A  25
GLU A  20
 None
 0.71A 3v4tA-3g64A:
undetectable
3v4tD-3g64A:
undetectable		 3v4tA-3g64A:
24.48
3v4tD-3g64A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3g64 PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
coelicolor) 		4 / 5 GLY A 274
ARG A 275
GLY A 254
GLU A 255
 None
 1.20A 4z2eB-3g64A:
undetectable
4z2eC-3g64A:
undetectable		 4z2eB-3g64A:
20.36
4z2eC-3g64A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3g64 PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
coelicolor) 		5 / 9 LEU A 164
LEU A 177
ALA A 132
VAL A 104
MET A 158
 None
 1.07A 5g44A-3g64A:
undetectable		 5g44A-3g64A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3g64 PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
coelicolor) 		3 / 3 LEU A  30
LEU A  17
TRP A  14
 None
 0.81A 5nwuA-3g64A:
undetectable		 5nwuA-3g64A:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3g64 PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
coelicolor) 		4 / 6 LEU A 251
GLN A 248
LEU A 243
LEU A 228
 None
 1.11A 5yvnA-3g64A:
undetectable		 5yvnA-3g64A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 3g64 PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
coelicolor) 		4 / 4 LEU A 228
ASP A 244
GLN A 248
VAL A  60
 None
 1.41A 6bzoF-3g64A:
undetectable		 6bzoF-3g64A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3g64 PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
coelicolor) 		3 / 3 HIS A 172
ARG A 190
ILE A 191
 None
 0.86A 6fgdA-3g64A:
undetectable		 6fgdA-3g64A:
24.48