SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		5 / 12 LEU A  55
LEU A 153
ILE A  61
VAL A 132
VAL A  28
 None
 1.36A 1hrkB-3g68A:
undetectable		 1hrkB-3g68A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		4 / 4 HIS A 215
ASP A 221
SER A  47
ASP A 217
 None
 1.12A 1n2xA-3g68A:
0.9		 1n2xA-3g68A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		4 / 5 GLU A 224
LEU A 230
LEU A 227
LEU A 229
 None
 1.11A 1np1A-3g68A:
undetectable		 1np1A-3g68A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		3 / 3 TYR A 308
ARG A 162
GLN A 159
 None
 1.00A 1tw4A-3g68A:
undetectable		 1tw4A-3g68A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		4 / 7 SER A 113
ILE A 129
ASP A 127
ASP A 123
 None
 1.01A 1yc5A-3g68A:
4.4		 1yc5A-3g68A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		5 / 12 PHE A 311
VAL A  51
VAL A 132
GLY A 157
LEU A 180
 None
 1.11A 2cbrA-3g68A:
undetectable		 2cbrA-3g68A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_A_SAMA1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		5 / 12 VAL A 270
ASN A 251
TYR A 250
SER A 257
TRP A 280
 None
 1.42A 2cl5A-3g68A:
undetectable		 2cl5A-3g68A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		4 / 6 ALA A 252
TYR A 240
ILE A 253
ILE A 249
 None
 1.21A 2dcfA-3g68A:
undetectable		 2dcfA-3g68A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		6 / 12 ALA A 225
ASP A 221
ILE A 218
GLY A 214
ILE A 213
ILE A 317
 None
 1.34A 2nmzB-3g68A:
undetectable		 2nmzB-3g68A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		4 / 7 GLY A  87
THR A  39
MET A 114
SER A  47
 None
 1.25A 2o5yH-3g68A:
undetectable
2o5yL-3g68A:
undetectable		 2o5yH-3g68A:
20.11
2o5yL-3g68A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		4 / 7 ILE A 314
THR A 149
ILE A 212
GLY A  42
 None
None
None
CIT  A 401 ( 3.7A)
 0.66A 2v0mB-3g68A:
undetectable		 2v0mB-3g68A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		5 / 12 ILE A 274
VAL A 270
ILE A 213
ILE A 246
VAL A 284
 None
 1.09A 3fpjB-3g68A:
undetectable		 3fpjB-3g68A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		5 / 12 LEU A 155
ILE A  18
PHE A 186
PHE A 311
SER A  47
 None
 1.23A 3ko0K-3g68A:
0.6
3ko0L-3g68A:
0.5
3ko0S-3g68A:
0.6
3ko0T-3g68A:
0.5		 3ko0K-3g68A:
14.66
3ko0L-3g68A:
14.66
3ko0S-3g68A:
14.66
3ko0T-3g68A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		4 / 5 GLU A 209
THR A 258
THR A 222
HIS A 215
 None
 1.26A 5axaC-3g68A:
3.0		 5axaC-3g68A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		3 / 3 ILE A 317
PRO A 316
ILE A 320
 None
 0.42A 5hw8F-3g68A:
undetectable		 5hw8F-3g68A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		3 / 3 LEU A 262
ILE A 218
TYR A 147
 None
 0.55A 5uunB-3g68A:
undetectable		 5uunB-3g68A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		5 / 7 ILE A 287
LEU A 204
THR A 281
THR A 232
ARG A 211
 None
 1.41A 5vc0A-3g68A:
undetectable		 5vc0A-3g68A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Clostridioides
difficile) 		4 / 6 SER A 113
GLY A  87
THR A  39
ILE A  71
 None
 0.83A 6f8cA-3g68A:
undetectable		 6f8cA-3g68A:
9.69