SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		4 / 7 ILE A  50
PHE A  53
ILE A 110
PRO A 123
 None
 0.93A 1oniB-3g69A:
undetectable
1oniC-3g69A:
undetectable		 1oniB-3g69A:
21.30
1oniC-3g69A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		4 / 5 LEU A 232
LEU A 140
CYH A 221
THR A 222
 None
 1.39A 2oaxD-3g69A:
undetectable		 2oaxD-3g69A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		3 / 3 LEU A 145
PRO A 146
ARG A  68
 None
 0.38A 2qd4B-3g69A:
undetectable		 2qd4B-3g69A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		5 / 12 ALA A 143
LEU A 139
LEU A 189
ARG A 237
ALA A 216
 None
 1.10A 3dfrA-3g69A:
undetectable		 3dfrA-3g69A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		5 / 10 ILE A 115
ILE A 122
GLY A 138
PRO A  87
LEU A 182
 None
 1.41A 3elzB-3g69A:
undetectable		 3elzB-3g69A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		5 / 9 VAL A 155
HIS A 153
VAL A 199
VAL A 197
GLN A 195
 None
 1.39A 3fi0A-3g69A:
undetectable		 3fi0A-3g69A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		5 / 9 VAL A 155
HIS A 153
VAL A 199
VAL A 197
GLN A 195
 None
 1.34A 3fi0C-3g69A:
undetectable		 3fi0C-3g69A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		5 / 9 VAL A 155
HIS A 153
VAL A 199
VAL A 197
GLN A 195
 None
 1.31A 3fi0J-3g69A:
undetectable		 3fi0J-3g69A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		5 / 9 VAL A 155
HIS A 153
VAL A 199
VAL A 197
GLN A 195
 None
 1.35A 3fi0O-3g69A:
undetectable		 3fi0O-3g69A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		4 / 5 ARG A 230
LEU A 232
VAL A 199
ASP A  86
 None
 1.14A 3ufnA-3g69A:
undetectable
3ufnB-3g69A:
undetectable		 3ufnA-3g69A:
19.16
3ufnB-3g69A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		5 / 12 MET A 124
ALA A 137
TYR A 191
GLY A 138
ILE A 156
 None
 1.47A 3vwqA-3g69A:
undetectable		 3vwqA-3g69A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		4 / 8 ILE A 156
LEU A 139
VAL A 147
GLY A 148
 None
 0.90A 3w1wA-3g69A:
undetectable		 3w1wA-3g69A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		4 / 5 HIS A 183
VAL A 113
GLU A 114
VAL A 188
 None
 1.11A 4p6vB-3g69A:
undetectable
4p6vE-3g69A:
undetectable		 4p6vB-3g69A:
17.79
4p6vE-3g69A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3g69 SORTASE C
(Streptococcus
pneumoniae) 		4 / 4 LEU A 219
ASP A  86
PRO A  87
ARG A 230
 None
 1.02A 6fgdA-3g69A:
undetectable		 6fgdA-3g69A:
21.30