SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3g6e 50S RIBOSOMAL
PROTEIN L22P
(Haloarcula
marismortui) 		4 / 4 HIS R  68
ALA R  77
PHE R  59
GLY R  67
 A  02841 ( 3.3A)
C  02087 ( 4.9A)
None
A  02841 ( 3.5A)
 1.15A 1mjoD-3g6eR:
undetectable		 1mjoD-3g6eR:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3g6e 50S RIBOSOMAL
PROTEIN L13P
(Haloarcula
marismortui) 		5 / 12 GLY J  77
LEU J 132
GLY J  20
ALA J  23
ALA J  27
 None
None
A  01242 ( 3.1A)
None
C  01103 ( 3.3A)
 0.94A 2bm9F-3g6eJ:
undetectable		 2bm9F-3g6eJ:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 3g6e 50S RIBOSOMAL
PROTEIN L23P
(Haloarcula
marismortui) 		4 / 7 VAL S  47
THR S  48
ARG S  67
LYS S  23
 None
None
C  01508 ( 4.3A)
C  01507 ( 2.6A)
 1.16A 2kotA-3g6eS:
undetectable		 2kotA-3g6eS:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3g6e 50S RIBOSOMAL
PROTEIN L13P
(Haloarcula
marismortui) 		5 / 10 VAL J  22
ALA J  23
VAL J 101
VAL J 103
VAL J  36
 None
None
None
G  02815 ( 4.2A)
None
 1.01A 2nnjA-3g6eJ:
undetectable		 2nnjA-3g6eJ:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3g6e 50S RIBOSOMAL
PROTEIN L22P
(Haloarcula
marismortui) 		4 / 5 ALA R  43
ALA R  95
ALA R  16
VAL R 143
 None
None
G  0 500 ( 4.1A)
None
 0.76A 2nyrB-3g6eR:
undetectable		 2nyrB-3g6eR:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3g6e 50S RIBOSOMAL
PROTEIN L22P
(Haloarcula
marismortui) 		4 / 6 ARG R  19
LEU R  91
MET R  17
ASP R 142
 G  0 500 ( 4.3A)
None
G  0 501 ( 4.8A)
None
 1.45A 4cevA-3g6eR:
undetectable
4cevB-3g6eR:
undetectable		 4cevA-3g6eR:
21.15
4cevB-3g6eR:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 3g6e 50S RIBOSOMAL
PROTEIN L22P
(Haloarcula
marismortui) 		4 / 6 MET R  17
ASP R 142
ARG R  19
LEU R  91
 G  0 501 ( 4.8A)
None
G  0 500 ( 4.3A)
None
 1.46A 4cevA-3g6eR:
undetectable
4cevC-3g6eR:
undetectable		 4cevA-3g6eR:
21.15
4cevC-3g6eR:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 3g6e 50S RIBOSOMAL
PROTEIN L22P
(Haloarcula
marismortui) 		4 / 6 ARG R  19
LEU R  91
MET R  17
ASP R 142
 G  0 500 ( 4.3A)
None
G  0 501 ( 4.8A)
None
 1.47A 4cevD-3g6eR:
undetectable
4cevE-3g6eR:
undetectable		 4cevD-3g6eR:
21.15
4cevE-3g6eR:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 3g6e 50S RIBOSOMAL
PROTEIN L22P
(Haloarcula
marismortui) 		4 / 6 ARG R  19
LEU R  91
MET R  17
ASP R 142
 G  0 500 ( 4.3A)
None
G  0 501 ( 4.8A)
None
 1.47A 4cevE-3g6eR:
undetectable
4cevF-3g6eR:
undetectable		 4cevE-3g6eR:
21.15
4cevF-3g6eR:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g6e 50S RIBOSOMAL
PROTEIN L13P
(Haloarcula
marismortui) 		5 / 10 VAL J 101
ALA J  97
SER J  24
LEU J 116
VAL J  36
 None
None
C  01102 ( 2.4A)
None
None
 1.42A 4eilB-3g6eJ:
undetectable		 4eilB-3g6eJ:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g6e 50S RIBOSOMAL
PROTEIN L13P
(Haloarcula
marismortui) 		5 / 11 VAL J 101
ALA J  97
SER J  24
LEU J 116
VAL J  36
 None
None
C  01102 ( 2.4A)
None
None
 1.43A 4eilC-3g6eJ:
undetectable		 4eilC-3g6eJ:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 3g6e 50S RIBOSOMAL
PROTEIN L11P
(Haloarcula
marismortui) 		4 / 4 LYS I 107
LEU I 111
ALA I 104
VAL I 100
 U  01164 ( 4.4A)
G  01163 ( 4.9A)
None
None
 1.44A 4ik6A-3g6eI:
undetectable		 4ik6A-3g6eI:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3g6e 50S RIBOSOMAL
PROTEIN L22P
(Haloarcula
marismortui) 		4 / 5 HIS R 113
VAL R 114
GLU R 144
VAL R   6
 G  0 525 ( 4.1A)
None
None
None
 1.36A 4p6vB-3g6eR:
undetectable
4p6vE-3g6eR:
undetectable		 4p6vB-3g6eR:
16.54
4p6vE-3g6eR:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3g6e 50S RIBOSOMAL
PROTEIN L22P
(Haloarcula
marismortui) 		4 / 6 VAL R 143
LEU R  47
ILE R  31
ALA R  32
 None
 0.63A 4zf8A-3g6eR:
undetectable		 4zf8A-3g6eR:
16.51