SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g79'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		5 / 8 LYS A 159
GLU A 163
ALA A 158
ALA A 228
THR A 229
 None
 1.22A 1ie4B-3g79A:
undetectable
1ie4D-3g79A:
undetectable		 1ie4B-3g79A:
16.44
1ie4D-3g79A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		5 / 10 ARG A  98
LEU A  47
ALA A  38
ILE A  81
GLY A  82
 None
 1.03A 1k6cA-3g79A:
undetectable		 1k6cA-3g79A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		4 / 6 PHE A 174
ALA A 175
LEU A 176
ILE A 202
 None
 0.94A 1sbrA-3g79A:
undetectable
1sbrB-3g79A:
undetectable		 1sbrA-3g79A:
17.34
1sbrB-3g79A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		3 / 3 LYS A 296
ASP A 369
ASN A 372
 None
 1.01A 2bm9A-3g79A:
4.1		 2bm9A-3g79A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		3 / 3 ASP A 369
ASP A 393
ASN A 372
 None
 0.84A 2bm9D-3g79A:
4.9		 2bm9D-3g79A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		5 / 12 LEU A  47
GLY A  48
VAL A 133
ALA A 108
MET A  26
 None
 1.09A 2oz7A-3g79A:
undetectable		 2oz7A-3g79A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		3 / 3 ASN A 250
LEU A 254
HIS A 335
 None
 0.69A 2q6fB-3g79A:
undetectable		 2q6fB-3g79A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		5 / 12 MET A 336
THR A 340
ALA A 343
GLU A 345
LEU A 347
 None
 1.15A 2qxsB-3g79A:
undetectable		 2qxsB-3g79A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		4 / 6 THR A 373
GLU A 376
MET A 358
ILE A 404
 None
 0.90A 2w98B-3g79A:
6.8		 2w98B-3g79A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		5 / 12 MET A 336
LEU A 339
THR A 340
ALA A 343
GLU A 345
 None
 1.16A 3hm1A-3g79A:
undetectable		 3hm1A-3g79A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		5 / 9 ALA A 228
LEU A 176
GLU A 155
ILE A 130
ILE A 149
 None
 1.32A 3jw3B-3g79A:
undetectable		 3jw3B-3g79A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		5 / 12 ARG A 326
ALA A 248
ILE A 246
ASP A 243
LEU A 244
 None
 1.23A 3lcvB-3g79A:
2.9		 3lcvB-3g79A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		4 / 6 ALA A 253
ILE A 468
HIS A 335
HIS A 474
 None
 1.05A 3nneG-3g79A:
2.6		 3nneG-3g79A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		5 / 10 ILE A  31
VAL A  35
GLY A  76
VAL A 217
LEU A  36
 None
 1.28A 3ogpB-3g79A:
undetectable		 3ogpB-3g79A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		5 / 10 LEU A  11
GLY A 201
ILE A 202
SER A   6
LEU A  12
 None
 1.03A 3ogpA-3g79A:
undetectable		 3ogpA-3g79A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		4 / 5 VAL A 199
ARG A 197
GLU A 146
LEU A 213
 None
 1.39A 4hojA-3g79A:
undetectable		 4hojA-3g79A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		4 / 8 LEU A 119
ARG A 326
VAL A 289
GLY A 290
 None
 0.95A 4klrB-3g79A:
2.0		 4klrB-3g79A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		3 / 3 HIS A 335
ASN A 338
ALA A 342
 None
 0.40A 5n4tB-3g79A:
undetectable		 5n4tB-3g79A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		4 / 7 ARG A 197
ALA A 177
THR A 154
ILE A 149
 None
 0.91A 5te8C-3g79A:
undetectable		 5te8C-3g79A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		3 / 3 MET A 358
GLU A 376
ARG A 379
 None
 1.00A 5tjyA-3g79A:
6.5		 5tjyA-3g79A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE
(Methanosarcina
mazei) 		3 / 3 LEU A 126
SER A 124
PHE A 123
 None
 0.61A 6fgcA-3g79A:
undetectable		 6fgcA-3g79A:
25.05