SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g7j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 5 LEU A  30
ILE A  52
SER A   9
GLY A   8
 None
GTX  A 220 (-4.2A)
GTX  A 220 (-3.2A)
GTX  A 220 (-3.7A)
 0.95A 2otfA-3g7jA:
undetectable		 2otfA-3g7jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 12 SER A 167
PRO A  53
VAL A  15
GLN A  70
LEU A  73
 None
GTX  A 220 (-4.3A)
None
None
None
 1.39A 2xrlA-3g7jA:
undetectable		 2xrlA-3g7jA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 8 SER A  66
ARG A  67
ALA A  10
THR A 174
 GTX  A 220 (-2.6A)
GTX  A 220 (-3.6A)
None
None
 0.96A 3bpxA-3g7jA:
undetectable
3bpxB-3g7jA:
undetectable		 3bpxA-3g7jA:
18.72
3bpxB-3g7jA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 6 GLN A  70
PHE A   3
PRO A  53
LEU A  55
 None
None
GTX  A 220 (-4.3A)
None
 1.24A 3tgvB-3g7jA:
undetectable		 3tgvB-3g7jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 6 GLN A  70
PHE A   3
PRO A  53
LEU A  55
 None
None
GTX  A 220 (-4.3A)
None
 1.23A 3tgvD-3g7jA:
undetectable		 3tgvD-3g7jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 11 VAL A  22
ALA A  79
PHE A  61
LEU A  55
VAL A  24
 None
 1.00A 4eilA-3g7jA:
undetectable		 4eilA-3g7jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 11 VAL A  22
ALA A  79
PHE A  61
LEU A  55
VAL A  24
 None
 1.03A 4eilC-3g7jA:
undetectable		 4eilC-3g7jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 11 VAL A  22
ALA A  79
PHE A  61
LEU A  55
VAL A  24
 None
 1.05A 4eilE-3g7jA:
undetectable		 4eilE-3g7jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 11 VAL A  22
ALA A  79
PHE A  61
LEU A  55
VAL A  24
 None
 0.94A 4kyaA-3g7jA:
undetectable		 4kyaA-3g7jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 10 VAL A  22
ALA A  79
PHE A  61
LEU A  55
VAL A  24
 None
 0.94A 4kyaC-3g7jA:
undetectable		 4kyaC-3g7jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 11 VAL A  22
ALA A  79
PHE A  61
LEU A  55
VAL A  24
 None
 0.94A 4kyaE-3g7jA:
undetectable		 4kyaE-3g7jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 11 VAL A  22
ALA A  79
PHE A  61
LEU A  55
VAL A  24
 None
 0.91A 4kyaG-3g7jA:
undetectable		 4kyaG-3g7jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 5 GLU A 116
GLY A 133
SER A 137
ARG A 113
 None
 1.13A 5kprA-3g7jA:
undetectable		 5kprA-3g7jA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 7 GLU A  65
TRP A  64
THR A  54
PRO A  53
 GTX  A 220 (-3.2A)
None
None
GTX  A 220 (-4.3A)
 1.41A 6a4iB-3g7jA:
3.6		 6a4iB-3g7jA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 9 ALA A 178
ALA A 209
GLY A 213
ALA A  10
GLY A   8
 None
None
None
None
GTX  A 220 (-3.7A)
 1.05A 6bklE-3g7jA:
undetectable
6bklF-3g7jA:
undetectable
6bklG-3g7jA:
undetectable
6bklH-3g7jA:
undetectable		 6bklE-3g7jA:
9.14
6bklF-3g7jA:
9.14
6bklG-3g7jA:
9.14
6bklH-3g7jA:
9.14