SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 12 GLN A  82
GLY A 305
GLY A  97
ASN A  98
PHE A  80
 None
 0.92A 1bx4A-3g7kA:
undetectable		 1bx4A-3g7kA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		4 / 6 ASN A 203
ILE A  99
ASN A 126
THR A 129
 None
 1.21A 1h7xA-3g7kA:
undetectable		 1h7xA-3g7kA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		4 / 6 ASN A 203
ILE A  99
ASN A 126
THR A 129
 None
 1.21A 1h7xB-3g7kA:
undetectable		 1h7xB-3g7kA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		4 / 6 ASN A 203
ILE A  99
ASN A 126
THR A 129
 None
 1.20A 1h7xC-3g7kA:
undetectable		 1h7xC-3g7kA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		4 / 6 ASN A 203
ILE A  99
ASN A 126
THR A 129
 None
 1.21A 1h7xD-3g7kA:
undetectable		 1h7xD-3g7kA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 12 GLY A 312
VAL A 177
ILE A 349
THR A 169
VAL A 201
 None
 0.94A 1k6cB-3g7kA:
undetectable		 1k6cB-3g7kA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 11 THR A 320
VAL A 199
THR A 311
ILE A 321
VAL A 322
 None
 1.21A 1phgA-3g7kA:
undetectable		 1phgA-3g7kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 11 ARG A 362
GLY A 342
VAL A 343
ASP A 275
ILE A 282
 None
 1.16A 1pk9C-3g7kA:
undetectable		 1pk9C-3g7kA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 12 THR A 129
PHE A 261
PHE A  80
ALA A 307
ALA A 304
 None
 1.22A 1q23A-3g7kA:
undetectable
1q23B-3g7kA:
undetectable		 1q23A-3g7kA:
18.60
1q23B-3g7kA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		4 / 6 PHE A  42
ALA A  54
LEU A  53
ILE A  11
 None
 1.07A 1sbrA-3g7kA:
undetectable
1sbrB-3g7kA:
undetectable		 1sbrA-3g7kA:
21.43
1sbrB-3g7kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 12 THR A  16
ASP A  57
ARG A 292
GLY A 342
ILE A 337
 None
 1.07A 1xvaA-3g7kA:
undetectable		 1xvaA-3g7kA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 10 ALA A 172
ALA A 202
PHE A 261
ALA A 173
ILE A  99
 None
 1.18A 2aclC-3g7kA:
undetectable		 2aclC-3g7kA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 11 ALA A 314
GLY A 305
THR A 306
ALA A 307
CYH A 205
 None
 1.19A 2f16V-3g7kA:
undetectable
2f16W-3g7kA:
undetectable		 2f16V-3g7kA:
20.10
2f16W-3g7kA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 11 ARG A 362
GLY A 342
VAL A 343
ASP A 275
ILE A 282
 None
 1.22A 3uawA-3g7kA:
undetectable		 3uawA-3g7kA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		4 / 8 SER A  44
GLN A  49
GLN A  82
PHE A 295
 None
 0.90A 4dx7B-3g7kA:
0.0		 4dx7B-3g7kA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		4 / 8 SER A  17
GLY A 154
THR A 302
GLY A 305
 None
 0.80A 4fo4B-3g7kA:
undetectable		 4fo4B-3g7kA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 12 PHE A  21
PHE A 295
ILE A  99
TYR A  78
THR A 306
 None
 1.20A 4mbsB-3g7kA:
0.0		 4mbsB-3g7kA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		4 / 5 LEU A  63
SER A  61
LEU A  39
LEU A  22
 None
 1.22A 4n09B-3g7kA:
undetectable		 4n09B-3g7kA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		4 / 5 LEU A  63
SER A  61
LEU A  39
LEU A  22
 None
 1.23A 4n09D-3g7kA:
undetectable		 4n09D-3g7kA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3g7k 3-METHYLITACONATE
ISOMERASE
(Eubacterium
barkeri) 		5 / 9 ARG A  13
ILE A 108
GLY A 104
GLY A 102
ALA A 144
 None
 1.01A 5o96A-3g7kA:
undetectable
5o96B-3g7kA:
undetectable		 5o96A-3g7kA:
20.10
5o96B-3g7kA:
20.10