SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.80A 1c6zA-3g7rA:
undetectable
1c6zA-3g7rA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.72A 1hxbA-3g7rA:
undetectable
1hxbA-3g7rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 10 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.96A 1muiA-3g7rA:
undetectable
1muiA-3g7rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 11 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.87A 1n49B-3g7rA:
undetectable
1n49B-3g7rA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 101
ALA A  95
SER A  97
GLY A 109
TYR A  28
None
None
IOD  A 203 (-3.6A)
None
None
1.24A 1nbiC-3g7rA:
undetectable
1nbiC-3g7rA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 101
ALA A  95
SER A  97
GLY A 109
TYR A  28
None
None
IOD  A 203 (-3.6A)
None
None
1.23A 1nbiD-3g7rA:
undetectable
1nbiD-3g7rA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.91A 1rl8A-3g7rA:
undetectable
1rl8A-3g7rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
6 / 12 LEU A 144
GLY A 157
ALA A 156
ASP A 193
GLY A 151
ALA A  87
None
None
EDO  A 967 ( 4.4A)
None
EDO  A 967 ( 3.3A)
None
1.35A 1rl8B-3g7rA:
undetectable
1rl8B-3g7rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
6 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
None
EDO  A 960 ( 4.8A)
0.99A 2bpxB-3g7rA:
undetectable
2bpxB-3g7rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.89A 2f8gB-3g7rA:
undetectable
2f8gB-3g7rA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.86A 2o4kB-3g7rA:
undetectable
2o4kB-3g7rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 9 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.90A 2o4pB-3g7rA:
undetectable
2o4pB-3g7rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.87A 2q63A-3g7rA:
undetectable
2q63A-3g7rA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.86A 2q63A-3g7rA:
undetectable
2q63A-3g7rA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
6 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
None
EDO  A 960 ( 4.8A)
1.05A 2q64B-3g7rA:
undetectable
2q64B-3g7rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
4 / 7 LEU A 138
VAL A 141
THR A 142
VAL A 190
None
0.87A 2qblA-3g7rA:
undetectable
2qblA-3g7rA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 11 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.89A 2qhcA-3g7rA:
undetectable
2qhcA-3g7rA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.90A 2z54B-3g7rA:
undetectable
2z54B-3g7rA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.88A 2z54B-3g7rA:
undetectable
2z54B-3g7rA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.78A 3bvbA-3g7rA:
undetectable
3bvbA-3g7rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.84A 3bvbA-3g7rA:
undetectable
3bvbA-3g7rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
6 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
None
EDO  A 960 ( 4.8A)
1.06A 3bvbB-3g7rA:
undetectable
3bvbB-3g7rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
3 / 3 GLU A 118
HIS A 127
HIS A 124
None
None
PEG  A 201 (-4.2A)
0.69A 3co4A-3g7rA:
undetectable
3co4A-3g7rA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 10 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.89A 3ekvA-3g7rA:
undetectable
3ekvA-3g7rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 11 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.78A 3ekxA-3g7rA:
undetectable
3ekxA-3g7rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 11 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.96A 3ekxB-3g7rA:
undetectable
3ekxB-3g7rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.85A 3el1B-3g7rA:
undetectable
3el1B-3g7rA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 10 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.89A 3em3A-3g7rA:
undetectable
3em3A-3g7rA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.86A 3em6B-3g7rA:
undetectable
3em6B-3g7rA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 LEU A 160
LEU A 163
ARG A 164
PHE A 137
ALA A 167
None
None
EDO  A 960 (-3.7A)
EDO  A 960 (-3.7A)
None
1.13A 3gwuA-3g7rA:
undetectable
3gwuA-3g7rA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.78A 3jw2A-3g7rA:
undetectable
3jw2A-3g7rA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.83A 3jw2A-3g7rA:
undetectable
3jw2A-3g7rA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
6 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
None
EDO  A 960 ( 4.8A)
0.90A 3jw2B-3g7rA:
undetectable
3jw2B-3g7rA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
6 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
None
EDO  A 960 ( 4.8A)
0.98A 3k4vB-3g7rA:
undetectable
3k4vB-3g7rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.88A 3lzuB-3g7rA:
undetectable
3lzuB-3g7rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.89A 3nu5A-3g7rA:
undetectable
3nu5A-3g7rA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.79A 3oxcA-3g7rA:
undetectable
3oxcA-3g7rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 9 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.92A 3oxvC-3g7rA:
undetectable
3oxvC-3g7rA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.85A 3tkwB-3g7rA:
undetectable
3tkwB-3g7rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.83A 3tkwB-3g7rA:
undetectable
3tkwB-3g7rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.88A 3tl9B-3g7rA:
undetectable
3tl9B-3g7rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.83A 3tl9B-3g7rA:
undetectable
3tl9B-3g7rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.88A 4dqfA-3g7rA:
undetectable
4dqfA-3g7rA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
4 / 6 PHE A  55
ALA A  64
ALA A  23
THR A  24
None
1.09A 4dtzB-3g7rA:
undetectable
4dtzB-3g7rA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 9 ALA A 167
VAL A  99
GLY A 186
VAL A  94
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.89A 4ll3B-3g7rA:
undetectable
4ll3B-3g7rA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
3 / 3 SER A 104
ASP A 100
GLN A  76
None
None
IOD  A 203 (-3.9A)
0.90A 4oltA-3g7rA:
undetectable
4oltB-3g7rA:
undetectable
4oltA-3g7rA:
24.15
4oltB-3g7rA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
3 / 3 GLN A  76
SER A 104
ASP A 100
IOD  A 203 (-3.9A)
None
None
0.81A 4qwpA-3g7rA:
undetectable
4qwpB-3g7rA:
undetectable
4qwpA-3g7rA:
24.15
4qwpB-3g7rA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
3 / 3 GLU A 118
ILE A  26
ALA A 111
None
0.59A 4wnwB-3g7rA:
0.6
4wnwB-3g7rA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
4 / 6 GLY A 109
TYR A  -4
ALA A 111
ARG A 164
None
None
None
EDO  A 960 (-3.7A)
1.16A 4yshB-3g7rA:
undetectable
4yshB-3g7rA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 11 GLY A 149
ALA A  87
VAL A 148
GLU A 143
ASP A 150
EDO  A 967 (-3.2A)
None
None
None
EDO  A 983 (-4.8A)
1.17A 5i3cC-3g7rA:
undetectable
5i3cC-3g7rA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
4 / 8 GLY A 166
ALA A 167
VAL A  99
GLY A 186
None
0.67A 5kr1B-3g7rA:
undetectable
5kr1B-3g7rA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 GLY A 166
ALA A 167
VAL A  99
GLY A 186
ILE A  98
None
None
None
None
EDO  A 960 ( 4.8A)
0.87A 6dilB-3g7rA:
undetectable
6dilB-3g7rA:
13.45