SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 6 ASN A 280
ILE A 277
ASN A 249
ASN A 224
 None
 1.15A 1h7xA-3g85A:
undetectable		 1h7xA-3g85A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 6 ASN A 280
ILE A 277
ASN A 249
ASN A 224
 None
 1.17A 1h7xB-3g85A:
4.2		 1h7xB-3g85A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 6 ASN A 280
ILE A 277
ASN A 249
ASN A 224
 None
 1.14A 1h7xC-3g85A:
undetectable		 1h7xC-3g85A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 6 ASN A 280
ILE A 277
ASN A 249
ASN A 224
 None
 1.15A 1h7xD-3g85A:
4.4		 1h7xD-3g85A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 8 ILE A 219
LEU A 188
PHE A 247
GLY A 169
 None
 0.83A 1os6A-3g85A:
undetectable		 1os6A-3g85A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 10 MET A 168
VAL A 163
ARG A 199
MET A 279
ILE A 297
 None
None
GOL  A 401 (-2.9A)
None
None
 1.18A 1pn0A-3g85A:
undetectable		 1pn0A-3g85A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 10 MET A 168
VAL A 163
ARG A 199
MET A 279
ILE A 297
 None
None
GOL  A 401 (-2.9A)
None
None
 1.18A 1pn0B-3g85A:
undetectable		 1pn0B-3g85A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 ILE A 307
ILE A 149
VAL A 161
PHE A 326
ILE A 299
 None
 0.98A 1xozA-3g85A:
undetectable		 1xozA-3g85A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 8 ILE A 297
ILE A  76
ASN A 162
VAL A 163
 None
 0.68A 2nniA-3g85A:
undetectable		 2nniA-3g85A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 7 ILE A 253
PRO A 290
ILE A 268
LEU A 261
ILE A 258
 None
 1.44A 2q83A-3g85A:
undetectable		 2q83A-3g85A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 10 GLU A 300
ILE A 297
GLY A 278
ILE A  80
MET A 196
 None
None
None
None
GOL  A 401 (-3.8A)
 1.24A 3adsA-3g85A:
undetectable		 3adsA-3g85A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 7 TYR A 158
LEU A 144
ALA A 126
TYR A 138
 None
 1.15A 3rodD-3g85A:
undetectable		 3rodD-3g85A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 8 ILE A 219
LEU A 188
PHE A 247
GLY A 169
 None
 0.84A 3selX-3g85A:
undetectable		 3selX-3g85A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 6 ILE A 219
LEU A 188
PHE A 247
GLY A 169
 None
 0.84A 3sj1X-3g85A:
undetectable		 3sj1X-3g85A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 7 ILE A 219
LEU A 188
PHE A 247
GLY A 169
 None
 0.79A 4hajA-3g85A:
undetectable		 4hajA-3g85A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 7 ILE A 219
LEU A 188
PHE A 247
GLY A 169
 None
 0.84A 4hbfA-3g85A:
undetectable		 4hbfA-3g85A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		4 / 7 ILE A 219
LEU A 188
PHE A 247
GLY A 169
 None
 0.78A 4hc3A-3g85A:
undetectable		 4hc3A-3g85A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 LEU A 261
PRO A 290
ILE A 187
LEU A 255
GLY A 228
 None
 1.08A 4l9qB-3g85A:
undetectable		 4l9qB-3g85A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 CYH A 248
LEU A 246
ALA A 185
ALA A 232
ILE A 253
 None
 1.02A 4o2bB-3g85A:
2.8		 4o2bB-3g85A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 CYH A 248
LEU A 246
ALA A 185
ALA A 232
ILE A 253
 None
 0.96A 4o2bD-3g85A:
4.0		 4o2bD-3g85A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		3 / 3 ASN A 193
ALA A 195
ARG A 199
 GOL  A 401 ( 3.8A)
GOL  A 401 ( 4.4A)
GOL  A 401 (-2.9A)
 0.67A 5cvtB-3g85A:
7.1		 5cvtB-3g85A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 CYH A 248
LEU A 246
ALA A 185
ALA A 232
ILE A 253
 None
 1.10A 5itzB-3g85A:
4.0		 5itzB-3g85A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 ASP A 251
GLY A 278
ALA A 195
PHE A 151
ASN A 152
 None
None
GOL  A 401 ( 4.4A)
None
GOL  A 401 (-4.6A)
 1.29A 5kc4E-3g85A:
undetectable		 5kc4E-3g85A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 GLU A 300
GLY A 278
ALA A 195
PHE A 151
ASN A 152
 None
None
GOL  A 401 ( 4.4A)
None
GOL  A 401 (-4.6A)
 1.10A 5kc4E-3g85A:
undetectable		 5kc4E-3g85A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 CYH A 248
LEU A 246
ALA A 185
ALA A 232
ILE A 253
 None
 1.01A 5mioB-3g85A:
2.8		 5mioB-3g85A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 ILE A 307
ILE A 127
PHE A 151
ALA A 129
ILE A  80
 None
 1.09A 5vceA-3g85A:
undetectable		 5vceA-3g85A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 11 VAL A 257
GLY A 256
ALA A 233
LEU A 261
ASN A 262
 None
 1.16A 5x6yA-3g85A:
3.1		 5x6yA-3g85A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 11 VAL A 257
GLY A 256
ALA A 233
LEU A 261
ASN A 262
 None
 1.12A 5x6yC-3g85A:
undetectable		 5x6yC-3g85A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)
(Clostridium
acetobutylicum) 		5 / 11 GLU A 301
ARG A  86
GLY A 278
PRO A 329
ILE A 331
 None
 1.10A 5yk2A-3g85A:
undetectable		 5yk2A-3g85A:
20.84