SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		5 / 10 LEU A 215
LEU A 308
THR A 300
ILE A 303
THR A 304
 None
 1.01A 1i18A-3g8dA:
undetectable
1i18B-3g8dA:
undetectable		 1i18A-3g8dA:
12.67
1i18B-3g8dA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		5 / 10 LEU A 215
LEU A 308
THR A 300
ILE A 303
THR A 304
 None
 1.01A 1i18A-3g8dA:
undetectable
1i18B-3g8dA:
undetectable		 1i18A-3g8dA:
12.67
1i18B-3g8dA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		5 / 11 ILE A  66
ALA A  69
VAL A   6
VAL A  42
ALA A  14
 None
 1.21A 1n4hA-3g8dA:
undetectable		 1n4hA-3g8dA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 VAL A  76
ALA A  77
HIS A  79
 None
 0.62A 1q23C-3g8dA:
undetectable		 1q23C-3g8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 VAL A  76
ALA A  77
HIS A  79
 None
 0.58A 1q23H-3g8dA:
undetectable		 1q23H-3g8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 VAL A  76
ALA A  77
HIS A  79
 None
 0.63A 1q23G-3g8dA:
undetectable		 1q23G-3g8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 VAL A  76
ALA A  77
HIS A  79
 None
 0.70A 1q23L-3g8dA:
undetectable		 1q23L-3g8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 THR A 304
GLU A 227
HIS A 333
 None
 0.81A 1xwfA-3g8dA:
5.1		 1xwfA-3g8dA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 THR A 304
GLU A 227
HIS A 333
 None
 0.81A 1xwfB-3g8dA:
5.6		 1xwfB-3g8dA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 THR A 304
GLU A 227
HIS A 333
 None
 0.83A 1xwfC-3g8dA:
2.7		 1xwfC-3g8dA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 THR A 304
GLU A 227
HIS A 333
 None
 0.83A 1xwfD-3g8dA:
5.2		 1xwfD-3g8dA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		5 / 8 ARG A 270
PHE A 102
THR A 109
ILE A 110
THR A 291
 None
 1.33A 3bpxA-3g8dA:
undetectable
3bpxB-3g8dA:
undetectable		 3bpxA-3g8dA:
17.66
3bpxB-3g8dA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		4 / 5 HIS A  32
ALA A  30
HIS A  41
TYR A  60
 None
 1.18A 4gboB-3g8dA:
undetectable		 4gboB-3g8dA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		5 / 12 ILE A 315
THR A 304
VAL A 328
ILE A 323
GLU A 326
 None
 1.42A 4i41A-3g8dA:
undetectable		 4i41A-3g8dA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		4 / 6 VAL A  31
VAL A   6
ILE A  78
LEU A  85
 None
 0.95A 4l1wB-3g8dA:
undetectable		 4l1wB-3g8dA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A  79
ILE A  26
ILE A   5
ALA A  77
 None
 0.78A 4lv9A-3g8dA:
undetectable		 4lv9A-3g8dA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		4 / 7 HIS A  79
ILE A  26
ILE A   5
ALA A  77
 None
 0.78A 4lv9B-3g8dA:
undetectable		 4lv9B-3g8dA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		6 / 7 LYS A 238
ASN A 290
ARG A 292
GLN A 294
VAL A 295
ARG A 338
 SO4  A1003 (-3.4A)
SO4  A1003 (-4.1A)
SO4  A1003 (-2.9A)
SO4  A1003 (-3.4A)
SO4  A1003 (-3.8A)
SO4  A1003 (-3.5A)
 0.28A 4mv7A-3g8dA:
63.9		 4mv7A-3g8dA:
82.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		4 / 5 HIS A 209
VAL A 210
GLU A 211
LYS A 238
 None
None
None
SO4  A1003 (-3.4A)
 1.08A 4p6vB-3g8dA:
undetectable
4p6vE-3g8dA:
undetectable		 4p6vB-3g8dA:
23.32
4p6vE-3g8dA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		4 / 8 GLY A 386
GLU A  12
GLU A 241
GLU A 336
 None
 0.86A 4rjdA-3g8dA:
undetectable
4rjdB-3g8dA:
undetectable		 4rjdA-3g8dA:
11.24
4rjdB-3g8dA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 ASP A  36
SER A  59
TYR A  60
 None
 0.86A 5glmA-3g8dA:
undetectable		 5glmA-3g8dA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		5 / 12 ILE A 293
THR A 304
ILE A 303
ALA A 243
GLU A 241
 None
 0.95A 5vceA-3g8dA:
undetectable		 5vceA-3g8dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 GLU A 311
LEU A 308
ARG A  16
 None
 0.64A 6d8fA-3g8dA:
3.5		 6d8fA-3g8dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		3 / 3 TYR A  60
ALA A  14
LEU A  39
 None
 0.71A 6d9kF-3g8dA:
3.7		 6d9kF-3g8dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3g8d BIOTIN CARBOXYLASE
(Escherichia
coli) 		4 / 6 LEU A 252
THR A 249
GLY A 247
ARG A 208
 None
 1.16A 6gtqB-3g8dA:
undetectable
6gtqD-3g8dA:
undetectable		 6gtqB-3g8dA:
17.34
6gtqD-3g8dA:
8.47