SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 5 GLY A 243
LEU A 246
THR A 247
VAL A 222
 None
 0.92A 1ekjF-3g8qA:
undetectable
1ekjG-3g8qA:
undetectable		 1ekjF-3g8qA:
23.88
1ekjG-3g8qA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 7 PRO A 156
LEU A 112
GLY A  88
LEU A  91
 None
 0.81A 1ya4B-3g8qA:
undetectable		 1ya4B-3g8qA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 10 LEU A  96
VAL A 101
GLY A 100
GLY A  92
ALA A  75
 None
 0.89A 2v3kA-3g8qA:
undetectable		 2v3kA-3g8qA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 10 ASP A  54
VAL A  50
GLY A  78
ALA A  77
ALA A  75
 None
 1.24A 3ucjA-3g8qA:
undetectable		 3ucjA-3g8qA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 8 VAL A 222
ILE A 242
SER A 235
ALA A 231
 None
 0.87A 4eyzA-3g8qA:
undetectable		 4eyzA-3g8qA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 8 VAL A 222
ILE A 242
SER A 235
ALA A 231
 None
 0.89A 4eyzB-3g8qA:
undetectable		 4eyzB-3g8qA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 6 ARG A  22
ASP A 109
GLY A  88
THR A  25
 None
 0.95A 4l1aB-3g8qA:
undetectable		 4l1aB-3g8qA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN
(Methanopyrus
kandleri) 		3 / 4 ARG A 191
GLY A 274
GLU A 276
 NA  A 302 (-4.0A)
None
None
 0.59A 4z2dB-3g8qA:
undetectable
4z2dC-3g8qA:
undetectable		 4z2dB-3g8qA:
21.58
4z2dC-3g8qA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 5 GLU A 135
GLY A 113
ARG A  65
GLY A  88
 None
 1.12A 5kprA-3g8qA:
undetectable		 5kprA-3g8qA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 8 LEU A  28
ALA A  77
VAL A  35
GLN A   8
 None
 1.00A 5nu7A-3g8qA:
undetectable		 5nu7A-3g8qA:
22.02