SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3g9h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 688
ASP A 843
ASN A 845
TYR A 642
 None
 1.32A 1hpkA-3g9hA:
undetectable		 1hpkA-3g9hA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 701
GLY A 697
ALA A 698
LEU A 671
 None
 0.76A 2wekB-3g9hA:
undetectable		 2wekB-3g9hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 739
GLY A 834
GLY A 830
THR A 857
ASN A 823
THR A 838
 None
 1.41A 2y7hC-3g9hA:
undetectable		 2y7hC-3g9hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 751
GLY A 811
LYS A 810
ARG A 775
 None
 0.77A 3bjwA-3g9hA:
undetectable		 3bjwA-3g9hA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 756
LEU A 804
SER A 720
THR A 801
 None
 1.01A 3d2tB-3g9hA:
undetectable		 3d2tB-3g9hA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 710
PHE A 816
ASP A 746
GLU A 745
 None
 1.07A 3kp6A-3g9hA:
undetectable
3kp6B-3g9hA:
undetectable		 3kp6A-3g9hA:
22.09
3kp6B-3g9hA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 870
VAL A 725
VAL A 812
ALA A 809
LEU A 727
 None
 1.05A 3sm2B-3g9hA:
undetectable		 3sm2B-3g9hA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 756
LEU A 804
SER A 720
THR A 801
 None
 1.04A 4d7bB-3g9hA:
undetectable		 4d7bB-3g9hA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 756
LEU A 804
SER A 720
THR A 801
 None
 1.04A 4i89A-3g9hA:
2.2		 4i89A-3g9hA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 756
LEU A 804
SER A 720
THR A 801
 None
 1.01A 4pwjB-3g9hA:
undetectable		 4pwjB-3g9hA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 698
ASN A 672
LEU A 671
 None
 0.50A 5i1nC-3g9hA:
undetectable		 5i1nC-3g9hA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 756
LEU A 804
SER A 720
THR A 801
 None
 1.04A 5l4iA-3g9hA:
undetectable		 5l4iA-3g9hA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 756
LEU A 804
SER A 720
THR A 801
 None
 1.04A 5l4iB-3g9hA:
undetectable		 5l4iB-3g9hA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 671
GLY A 697
VAL A 686
ILE A 616
ILE A 676
 None
 1.01A 6dh3B-3g9hA:
undetectable		 6dh3B-3g9hA:
16.85