SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ga3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 3ga3 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1, MDA5
(Homo
sapiens) 		4 / 7 MET A 972
TYR A1015
ASP A 953
HIS A 927
 None
 1.40A 2bytA-3ga3A:
undetectable		 2bytA-3ga3A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 3ga3 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1, MDA5
(Homo
sapiens) 		4 / 7 MET A 972
TYR A1015
ASP A 953
HIS A 927
 None
 1.40A 2bytD-3ga3A:
undetectable		 2bytD-3ga3A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 3ga3 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1, MDA5
(Homo
sapiens) 		5 / 12 ILE A1008
PRO A 900
ILE A 984
HIS A 928
PHE A1010
 None
 1.42A 2oa1A-3ga3A:
undetectable		 2oa1A-3ga3A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 3ga3 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1, MDA5
(Homo
sapiens) 		5 / 12 ILE A1008
PRO A 900
ILE A 984
HIS A 928
PHE A1010
 None
 1.46A 2oa1B-3ga3A:
undetectable		 2oa1B-3ga3A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3ga3 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1, MDA5
(Homo
sapiens) 		3 / 3 HIS A1021
GLU A1017
ASN A1012
 None
 1.02A 5wbvA-3ga3A:
undetectable		 5wbvA-3ga3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3ga3 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1, MDA5
(Homo
sapiens) 		3 / 3 HIS A1021
GLU A1017
ASN A1012
 None
 1.02A 5wbvB-3ga3A:
undetectable		 5wbvB-3ga3A:
18.73