SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ga4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3ga4 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE-PROTEI
N
GLYCOSYLTRANSFERASE
SUBUNIT OST6
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 150
ASN A 152
GLY A 144
PHE A 146
ALA A  76
 None
None
None
EDO  A 182 ( 4.9A)
None
 1.23A 1hvyB-3ga4A:
undetectable		 1hvyB-3ga4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3ga4 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE-PROTEI
N
GLYCOSYLTRANSFERASE
SUBUNIT OST6
(Saccharomyces
cerevisiae) 		4 / 7 HIS A  66
THR A  85
ASN A  39
LEU A 106
 None
 0.91A 1qzrB-3ga4A:
undetectable		 1qzrB-3ga4A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3ga4 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE-PROTEI
N
GLYCOSYLTRANSFERASE
SUBUNIT OST6
(Saccharomyces
cerevisiae) 		4 / 4 THR A  85
VAL A 103
GLY A  47
THR A  48
 None
 1.09A 3cflA-3ga4A:
undetectable		 3cflA-3ga4A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3ga4 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE-PROTEI
N
GLYCOSYLTRANSFERASE
SUBUNIT OST6
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  73
ILE A  40
THR A  44
 None
 0.67A 3ia4D-3ga4A:
undetectable		 3ia4D-3ga4A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3ga4 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE-PROTEI
N
GLYCOSYLTRANSFERASE
SUBUNIT OST6
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 130
LEU A  57
PHE A  61
TYR A  42
 EDO  A 182 (-4.2A)
None
None
None
 1.13A 3po7A-3ga4A:
undetectable		 3po7A-3ga4A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3ga4 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE-PROTEI
N
GLYCOSYLTRANSFERASE
SUBUNIT OST6
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 144
ARG A  73
ILE A 155
LEU A 141
 None
 0.99A 4acbC-3ga4A:
undetectable		 4acbC-3ga4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ga4 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE-PROTEI
N
GLYCOSYLTRANSFERASE
SUBUNIT OST6
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  98
TYR A 109
SER A  31
 PG4  A 178 (-4.0A)
None
None
 0.69A 5iktA-3ga4A:
undetectable		 5iktA-3ga4A:
16.22