SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gaf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		4 / 8 SER A 145
VAL A 166
GLY A 160
GLY A 149
 None
 0.71A 1aq7A-3gafA:
undetectable		 1aq7A-3gafA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		4 / 5 SER A 145
ASN A 167
ALA A 164
GLU A 150
 None
 1.20A 1lqtA-3gafA:
5.4
1lqtB-3gafA:
5.7		 1lqtA-3gafA:
20.92
1lqtB-3gafA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		4 / 5 SER A 145
ASN A 167
ALA A 164
GLU A 150
 None
 1.21A 1lquA-3gafA:
5.8
1lquB-3gafA:
5.2		 1lquA-3gafA:
20.92
1lquB-3gafA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		4 / 6 SER A 145
VAL A 166
GLY A 160
GLY A 149
 None
 0.69A 1tnlA-3gafA:
undetectable		 1tnlA-3gafA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		4 / 4 SER A 145
ILE A 144
VAL A 246
THR A 213
 None
 1.23A 1u70A-3gafA:
undetectable		 1u70A-3gafA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		4 / 5 ALA A  19
ALA A  32
ALA A  36
VAL A  91
 None
 0.85A 2nyrB-3gafA:
4.8		 2nyrB-3gafA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		5 / 12 GLY A  18
ALA A  20
LEU A  43
VAL A  69
LEU A 117
 None
 0.87A 2nyuA-3gafA:
9.2		 2nyuA-3gafA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		5 / 12 GLY A  18
ALA A  26
LEU A  43
VAL A  69
LEU A 117
 None
 1.01A 2nyuA-3gafA:
9.2		 2nyuA-3gafA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		6 / 12 GLY A  18
ALA A  20
LEU A  43
VAL A  69
THR A  70
LEU A 117
 None
 0.83A 2nyuB-3gafA:
4.2		 2nyuB-3gafA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		4 / 6 SER A 145
VAL A 166
GLY A 160
GLY A 149
 None
 0.74A 2otvA-3gafA:
undetectable		 2otvA-3gafA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ILE A  27
ALA A  26
GLY A  22
ILE A 224
GLY A  18
 None
 0.78A 2qe6A-3gafA:
6.6		 2qe6A-3gafA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ILE A  27
ALA A  26
GLY A  22
ILE A 224
GLY A  18
 None
 0.84A 2qe6B-3gafA:
6.3		 2qe6B-3gafA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		4 / 8 SER A 145
VAL A 166
GLY A 160
GLY A 149
 None
 0.67A 2vinA-3gafA:
undetectable		 2vinA-3gafA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		4 / 7 ALA A 188
SER A 247
THR A 245
VAL A 243
 None
 0.92A 3ozkB-3gafA:
undetectable		 3ozkB-3gafA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		5 / 11 ILE A  27
ILE A  23
GLY A  22
VAL A 246
GLY A 219
 None
 0.95A 4ac9B-3gafA:
6.3
4ac9C-3gafA:
6.2		 4ac9B-3gafA:
21.58
4ac9C-3gafA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		5 / 12 THR A 170
GLY A 241
ILE A 141
SER A 126
ASN A 167
 None
 1.39A 4pooB-3gafA:
8.7		 4pooB-3gafA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		5 / 9 ILE A  27
ASN A  94
VAL A 184
ILE A 182
PHE A  31
 None
 1.28A 4r38C-3gafA:
undetectable		 4r38C-3gafA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ILE A 187
ILE A 144
VAL A  93
VAL A  91
LEU A   9
 None
 1.18A 4y0pA-3gafA:
undetectable		 4y0pA-3gafA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		5 / 12 PHE A  31
PHE A  86
ALA A  26
ALA A  54
GLY A  60
 None
 0.84A 5veuA-3gafA:
undetectable		 5veuA-3gafA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE
(Brucella
abortus) 		4 / 7 LEU A 201
LEU A 197
ALA A 191
THR A 213
 None
 0.67A 6a7jA-3gafA:
undetectable		 6a7jA-3gafA:
14.88