SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 7 MET A 260
PHE A 301
MET A 293
ALA A 289
 None
 1.21A 1linA-3gayA:
undetectable		 1linA-3gayA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 ASN A 253
GLU A 133
HIS A 210
ALA A 169
 P6T  A 327 (-3.8A)
None
ZN  A 326 ( 3.3A)
None
 0.92A 2bnnA-3gayA:
undetectable
2bnnB-3gayA:
undetectable		 2bnnA-3gayA:
20.12
2bnnB-3gayA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 LEU A  10
GLU A 133
HIS A 210
ALA A 169
 None
None
ZN  A 326 ( 3.3A)
None
 0.87A 2bnnA-3gayA:
undetectable
2bnnB-3gayA:
undetectable		 2bnnA-3gayA:
20.12
2bnnB-3gayA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 MET A   9
SER A 303
TYR A  18
TYR A 310
 None
 1.23A 2bteA-3gayA:
undetectable		 2bteA-3gayA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 ILE A 241
ALA A  13
VAL A 254
PHE A 301
SER A  43
 None
None
P6T  A 327 (-4.3A)
None
None
 1.20A 2gl0A-3gayA:
undetectable
2gl0C-3gayA:
undetectable		 2gl0A-3gayA:
18.90
2gl0C-3gayA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 PHE A 301
SER A  43
ILE A 241
ALA A  13
VAL A 254
 None
None
None
None
P6T  A 327 (-4.3A)
 1.28A 2gl0D-3gayA:
undetectable
2gl0E-3gayA:
undetectable		 2gl0D-3gayA:
18.90
2gl0E-3gayA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 MET A   9
SER A 303
TYR A  18
TYR A 310
 None
 1.34A 2v0gA-3gayA:
undetectable		 2v0gA-3gayA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 ASN A  24
THR A 176
VAL A 236
ILE A 241
ILE A 252
 P6T  A 327 (-3.5A)
None
None
None
None
 1.22A 3kpbA-3gayA:
undetectable		 3kpbA-3gayA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 ILE A 245
VAL A  38
ILE A  34
ILE A 252
ALA A  13
 None
 1.24A 3ohtA-3gayA:
undetectable
3ohtB-3gayA:
undetectable		 3ohtA-3gayA:
21.27
3ohtB-3gayA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 9 ARG A  14
LEU A 207
ALA A 158
ASP A 157
ILE A 199
 None
 1.45A 3wsjA-3gayA:
undetectable		 3wsjA-3gayA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 ILE A 238
ILE A 241
VAL A 254
GLY A  21
 None
None
P6T  A 327 (-4.3A)
None
 0.71A 4acaC-3gayA:
2.1		 4acaC-3gayA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 ILE A  34
GLY A  33
VAL A 254
SER A 214
 None
None
P6T  A 327 (-4.3A)
None
 0.80A 4acbB-3gayA:
undetectable
4acbC-3gayA:
2.8		 4acbB-3gayA:
22.63
4acbC-3gayA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 ILE A 238
ILE A 241
VAL A 254
GLY A  21
 None
None
P6T  A 327 (-4.3A)
None
 0.72A 4acbC-3gayA:
2.8		 4acbC-3gayA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 4 HIS A 109
GLU A 135
HIS A  84
LEU A  82
 None
None
ZN  A 326 (-3.4A)
None
 1.48A 4m2rA-3gayA:
undetectable		 4m2rA-3gayA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 6 LEU A 136
PHE A 161
THR A 165
VAL A 122
 None
 1.10A 4udaA-3gayA:
undetectable		 4udaA-3gayA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 5 GLU A 163
THR A 203
THR A 118
HIS A 109
 None
 1.18A 5axaA-3gayA:
undetectable		 5axaA-3gayA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 5 GLU A 163
THR A 203
THR A 118
HIS A 109
 None
 1.19A 5axaC-3gayA:
undetectable		 5axaC-3gayA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 6 SER A 107
ALA A 106
MET A 103
LEU A 136
 None
 1.26A 5dzkB-3gayA:
undetectable
5dzkP-3gayA:
undetectable		 5dzkB-3gayA:
25.15
5dzkP-3gayA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 ILE A  46
LEU A   6
SER A 303
GLY A  21
GLY A  19
 None
 1.15A 5nnaA-3gayA:
1.6		 5nnaA-3gayA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 ILE A  46
LEU A   6
SER A 303
GLY A  21
GLY A  19
 None
 1.15A 5nnaB-3gayA:
undetectable		 5nnaB-3gayA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 ILE A  46
LEU A   6
SER A 303
GLY A  21
GLY A  19
 None
 1.15A 5nnaC-3gayA:
undetectable		 5nnaC-3gayA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 ILE A  46
LEU A   6
SER A 303
GLY A  21
GLY A  19
 None
 1.13A 5nnaD-3gayA:
1.5		 5nnaD-3gayA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 ASP A 168
HIS A  81
GLY A 129
LEU A 315
 None
 0.69A 5w3jB-3gayA:
undetectable		 5w3jB-3gayA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 6 SER A 107
GLY A 137
THR A 153
ILE A 199
 None
 0.80A 6f8cA-3gayA:
undetectable		 6f8cA-3gayA:
11.29