SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gaz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 8 GLY A  99
GLY A  97
MET A  69
LEU A  47
 None
 0.76A 1aegA-3gazA:
undetectable		 1aegA-3gazA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 9 ILE A 156
LEU A 246
VAL A 163
GLY A 162
ALA A 167
 None
None
None
CA  A 401 ( 3.7A)
None
 1.21A 1e7aA-3gazA:
undetectable		 1e7aA-3gazA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 PHE A 281
LEU A  47
TYR A 315
GLY A  97
GLY A  93
 None
 1.07A 1fe2A-3gazA:
undetectable		 1fe2A-3gazA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 PHE A 281
LEU A  47
TYR A 315
GLY A  97
GLY A  93
 None
 1.07A 1igxA-3gazA:
undetectable		 1igxA-3gazA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 LEU A 272
GLY A  96
VAL A  37
LEU A  71
LEU A 278
 None
 1.10A 1mx1B-3gazA:
undetectable		 1mx1B-3gazA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 6 PHE A  20
GLU A 310
ARG A  52
ILE A 333
 None
 1.24A 1nsiC-3gazA:
0.0
1nsiD-3gazA:
undetectable		 1nsiC-3gazA:
22.57
1nsiD-3gazA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A  43
ILE A  66
GLY A  96
VAL A  37
ILE A  39
 None
 0.89A 2aquB-3gazA:
undetectable		 2aquB-3gazA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.75A 2avoB-3gazA:
undetectable		 2avoB-3gazA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.76A 2bpxB-3gazA:
undetectable		 2bpxB-3gazA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A  43
ILE A  66
GLY A  96
VAL A  37
ILE A  39
 None
 0.90A 2fxeB-3gazA:
undetectable		 2fxeB-3gazA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.72A 2fxeB-3gazA:
undetectable		 2fxeB-3gazA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.72A 2hs1B-3gazA:
undetectable		 2hs1B-3gazA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 ARG A  52
ILE A 333
PHE A  20
GLU A 310
 None
 1.33A 2nsiA-3gazA:
undetectable
2nsiB-3gazA:
undetectable		 2nsiA-3gazA:
22.57
2nsiB-3gazA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 PHE A  20
GLU A 310
ARG A  52
ILE A 333
 None
 1.29A 2nsiA-3gazA:
undetectable
2nsiB-3gazA:
undetectable		 2nsiA-3gazA:
22.57
2nsiB-3gazA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 ARG A  52
ILE A 333
PHE A  20
GLU A 310
 None
 1.27A 2nsiC-3gazA:
undetectable
2nsiD-3gazA:
undetectable		 2nsiC-3gazA:
22.57
2nsiD-3gazA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 PHE A  20
GLU A 310
ARG A  52
ILE A 333
 None
 1.27A 2nsiC-3gazA:
undetectable
2nsiD-3gazA:
undetectable		 2nsiC-3gazA:
22.57
2nsiD-3gazA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.62A 2o4sA-3gazA:
undetectable		 2o4sA-3gazA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.76A 2r5pB-3gazA:
undetectable		 2r5pB-3gazA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.76A 2r5pD-3gazA:
undetectable		 2r5pD-3gazA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 9 VAL A 134
VAL A 163
PRO A  46
THR A  44
GLY A  43
 None
None
CA  A 401 ( 4.7A)
None
None
 1.40A 3bjwG-3gazA:
undetectable		 3bjwG-3gazA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.77A 3bvbA-3gazA:
undetectable		 3bvbA-3gazA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.70A 3d1xA-3gazA:
undetectable		 3d1xA-3gazA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.67A 3d1yA-3gazA:
undetectable		 3d1yA-3gazA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 158
GLY A 160
ALA A 200
THR A 181
LEU A 155
 None
 1.09A 3dh0B-3gazA:
8.4		 3dh0B-3gazA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 PHE A  20
GLU A 310
ARG A  52
ILE A 333
 None
 1.25A 3e7gA-3gazA:
undetectable
3e7gB-3gazA:
undetectable		 3e7gA-3gazA:
22.83
3e7gB-3gazA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 ARG A  52
ILE A 333
PHE A  20
GLU A 310
 None
 1.26A 3e7gC-3gazA:
undetectable
3e7gD-3gazA:
0.0		 3e7gC-3gazA:
22.83
3e7gD-3gazA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.74A 3el1B-3gazA:
undetectable		 3el1B-3gazA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.85A 3em4A-3gazA:
undetectable		 3em4A-3gazA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A  43
ILE A  66
GLY A  96
VAL A  37
ILE A  39
 None
 0.92A 3em4U-3gazA:
undetectable		 3em4U-3gazA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 158
THR A 223
ASP A 199
ILE A 198
ASP A 222
 None
 1.32A 3iv6B-3gazA:
9.1		 3iv6B-3gazA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 ASN A 275
ALA A  56
VAL A  98
LEU A 133
PHE A 267
 None
 1.29A 3jwqB-3gazA:
undetectable
3jwqC-3gazA:
undetectable		 3jwqB-3gazA:
19.15
3jwqC-3gazA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.77A 3nu3A-3gazA:
undetectable		 3nu3A-3gazA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.82A 3nu5A-3gazA:
undetectable		 3nu5A-3gazA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 PHE A  85
GLY A  93
THR A  95
VAL A 111
 None
 1.01A 3wrkD-3gazA:
undetectable		 3wrkD-3gazA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 6 ASP A  70
THR A 334
ILE A 333
THR A  95
 None
 1.06A 4acbC-3gazA:
2.6		 4acbC-3gazA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 LEU A 187
GLU A 188
SER A 185
 None
 0.83A 4ccqA-3gazA:
2.9		 4ccqA-3gazA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 8 PHE A  20
GLU A 310
ARG A  52
ILE A 333
 None
 1.30A 4cx7A-3gazA:
undetectable
4cx7B-3gazA:
undetectable		 4cx7A-3gazA:
22.57
4cx7B-3gazA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 PHE A  20
GLU A 310
ARG A  52
ILE A 333
 None
 1.33A 4cx7C-3gazA:
undetectable
4cx7D-3gazA:
undetectable		 4cx7C-3gazA:
22.57
4cx7D-3gazA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  96
GLY A 103
ILE A 136
GLY A  93
LEU A 285
 None
 1.10A 4n48A-3gazA:
6.8		 4n48A-3gazA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 109
GLY A  96
GLY A 103
GLY A  93
LEU A 285
 None
 0.73A 4n48B-3gazA:
6.7		 4n48B-3gazA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 320
ASP A 323
ILE A 331
GLN A 327
ASN A 322
 None
None
None
CA  A 401 (-4.0A)
None
 1.36A 4pooB-3gazA:
9.3		 4pooB-3gazA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 6 LEU A  71
LEU A  36
PHE A 108
VAL A 335
 None
 1.01A 4udaA-3gazA:
undetectable		 4udaA-3gazA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 CYH A 245
LEU A 246
THR A 181
VAL A 163
ILE A 156
 None
 1.13A 4x1yB-3gazA:
3.6		 4x1yB-3gazA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 CYH A 245
LEU A 246
THR A 181
VAL A 163
ILE A 156
 None
 1.02A 4x20B-3gazA:
undetectable		 4x20B-3gazA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 ILE A 311
GLY A  68
ILE A 333
LEU A  67
 None
 0.87A 5dzkl-3gazA:
undetectable
5dzkz-3gazA:
undetectable		 5dzkl-3gazA:
19.41
5dzkz-3gazA:
0.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A 198
TYR A 207
GLY A 158
THR A 223
HIS A 251
 None
 1.17A 5esgA-3gazA:
undetectable		 5esgA-3gazA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A 198
TYR A 207
GLY A 158
THR A 223
HIS A 251
 None
 1.22A 5eslA-3gazA:
undetectable		 5eslA-3gazA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 6 GLU A 283
GLY A 282
ARG A 286
PHE A  85
 None
 1.18A 5jcnB-3gazA:
3.4		 5jcnB-3gazA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  43
ILE A  66
GLY A  97
VAL A  37
ILE A  39
 None
 0.57A 5kqxA-3gazA:
undetectable		 5kqxA-3gazA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 ALA A 180
THR A 181
ALA A 182
VAL A 178
GLY A 164
 None
 0.89A 5lf7K-3gazA:
undetectable
5lf7L-3gazA:
undetectable		 5lf7K-3gazA:
21.28
5lf7L-3gazA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A 168
GLY A 164
ALA A 180
ALA A 195
VAL A 154
 None
 1.14A 5n0oB-3gazA:
2.4		 5n0oB-3gazA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 GLU A 188
TYR A 189
ARG A 300
 None
 0.86A 5uunA-3gazA:
undetectable		 5uunA-3gazA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 GLU A 188
TYR A 189
ARG A 300
 None
 0.77A 5uunB-3gazA:
undetectable		 5uunB-3gazA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A 198
TYR A 207
GLY A 158
THR A 223
HIS A 251
 None
 1.30A 5v5zA-3gazA:
undetectable		 5v5zA-3gazA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 8 VAL A 111
ASP A 112
GLY A 282
LEU A 285
 None
 0.82A 5w3jB-3gazA:
3.1		 5w3jB-3gazA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 285
LEU A 131
THR A 137
VAL A 163
THR A 268
 None
 1.19A 6debB-3gazA:
6.6		 6debB-3gazA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 10 VAL A 111
LEU A 115
GLY A 103
GLY A  73
VAL A  37
 None
 1.11A 6eu9B-3gazA:
undetectable		 6eu9B-3gazA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 SER A 232
GLY A 164
GLY A 159
LEU A 193
VAL A 190
 None
 1.19A 6i5zD-3gazA:
5.7		 6i5zD-3gazA:
25.23