SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		5 / 12 GLN A 288
ASP A 145
VAL A 144
HIS A 143
ALA A 287
 None
 1.35A 2g70A-3gb4A:
undetectable		 2g70A-3gb4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		5 / 12 GLN A 288
ASP A 145
VAL A 144
HIS A 143
ALA A 287
 None
 1.29A 2g70B-3gb4A:
undetectable		 2g70B-3gb4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		4 / 8 ASP A 294
LEU A 290
TYR A 263
HIS A 165
 CO  A 502 (-1.9A)
None
None
CO  A 502 (-3.3A)
 1.05A 3af0A-3gb4A:
undetectable		 3af0A-3gb4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		4 / 7 ASP A 294
HIS A 165
LEU A 155
ASN A 230
 CO  A 502 (-1.9A)
CO  A 502 (-3.3A)
None
D3M  A 601 (-2.8A)
 1.00A 3avpA-3gb4A:
undetectable		 3avpA-3gb4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		3 / 3 LYS A  21
PRO A  22
LEU A  23
 None
 0.87A 3tpxE-3gb4A:
undetectable		 3tpxE-3gb4A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		4 / 7 TYR A 148
VAL A 152
VAL A   5
ILE A 252
 None
 0.88A 3zjqA-3gb4A:
undetectable		 3zjqA-3gb4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		4 / 7 TYR A 148
VAL A 152
VAL A   5
ILE A 252
 None
 0.88A 3zjqB-3gb4A:
undetectable		 3zjqB-3gb4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		4 / 8 PRO A  55
ASP A  47
SER A  57
ASP A  58
 None
 0.98A 4k0bB-3gb4A:
undetectable		 4k0bB-3gb4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		4 / 8 PRO A  55
ASP A  47
SER A  57
ASP A  58
 None
 0.97A 4l7iB-3gb4A:
undetectable		 4l7iB-3gb4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		5 / 12 GLY A 266
SER A 267
VAL A 144
CYH A 146
LEU A 151
 None
 1.14A 5ergB-3gb4A:
undetectable		 5ergB-3gb4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		4 / 7 LEU A 158
ILE A 331
TRP A 222
MET A 228
 D3M  A 601 ( 4.0A)
None
None
None
 1.43A 5ljcA-3gb4A:
1.9		 5ljcA-3gb4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		3 / 3 ASP A 294
ASN A 154
ASP A 157
 CO  A 502 (-1.9A)
CO  A 502 (-3.9A)
None
 0.69A 5vopA-3gb4A:
undetectable		 5vopA-3gb4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		3 / 3 ASP A 294
ASN A 154
ASP A 157
 CO  A 502 (-1.9A)
CO  A 502 (-3.9A)
None
 0.69A 5vopB-3gb4A:
undetectable		 5vopB-3gb4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3gb4 DDMC
(Stenotrophomonas
maltophilia) 		3 / 3 ARG A 283
ARG A 130
ARG A 136
 None
 0.97A 6bplA-3gb4A:
undetectable
6bplB-3gb4A:
undetectable		 6bplA-3gb4A:
12.39
6bplB-3gb4A:
12.39