SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		5 / 12 TYR A 184
THR A 303
GLY A 301
ILE A 194
LEU A 113
 None
 1.17A 1r30A-3gbfA:
undetectable		 1r30A-3gbfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		5 / 12 TYR A 184
THR A 303
GLY A 301
ILE A 194
LEU A 113
 None
 1.17A 1r30B-3gbfA:
undetectable		 1r30B-3gbfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_A_FCNA1199_1
(EPOXIDASE)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		5 / 9 ARG A  90
TYR A  98
ASN A 126
HIS A 129
HIS A 182
 2HE  A 550 (-3.8A)
2HE  A 550 (-4.4A)
2HE  A 550 (-3.8A)
CD  A 513 ( 3.5A)
CD  A 513 ( 3.5A)
 0.78A 2bnnA-3gbfA:
12.4
2bnnB-3gbfA:
11.1		 2bnnA-3gbfA:
18.59
2bnnB-3gbfA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		4 / 7 LEU A 367
LEU A 380
PRO A 110
GLU A 355
 None
 1.03A 2jn3A-3gbfA:
undetectable		 2jn3A-3gbfA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		3 / 3 ASP A 309
ARG A 312
ARG A 157
 CD  A 505 (-2.1A)
CD  A 505 ( 4.5A)
None
 0.98A 3k37A-3gbfA:
undetectable		 3k37A-3gbfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		5 / 12 ALA A 253
LEU A 276
LEU A 279
SER A 248
GLY A 272
 None
 1.39A 3lbdA-3gbfA:
undetectable		 3lbdA-3gbfA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		4 / 5 ARG A 246
LEU A 260
PRO A 267
ASP A 236
 None
 1.17A 3ufnA-3gbfA:
undetectable
3ufnB-3gbfA:
undetectable		 3ufnA-3gbfA:
12.19
3ufnB-3gbfA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		4 / 5 LEU A 113
HIS A 182
GLU A 176
HIS A 129
 None
CD  A 513 ( 3.5A)
2HE  A 550 ( 2.5A)
CD  A 513 ( 3.5A)
 1.22A 4a7bB-3gbfA:
undetectable		 4a7bB-3gbfA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		4 / 7 ASP A 309
GLY A 171
THR A 170
ILE A 169
 CD  A 505 (-2.1A)
None
None
None
 0.89A 4acaC-3gbfA:
undetectable		 4acaC-3gbfA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		4 / 6 THR A 303
GLN A 296
THR A 198
HIS A 129
 None
CD  A 512 ( 3.7A)
None
CD  A 513 ( 3.5A)
 1.26A 4pfjB-3gbfA:
undetectable		 4pfjB-3gbfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		4 / 8 HIS A 160
ASN A 137
GLY A 145
VAL A 158
 CD  A 508 (-3.4A)
None
None
None
 1.01A 5m8rC-3gbfA:
undetectable		 5m8rC-3gbfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3gbf PHPD
(Streptomyces
viridochromogene
s) 		4 / 4 LEU A 283
LEU A 279
SER A 248
ALA A 250
 None
 1.11A 5uunA-3gbfA:
undetectable		 5uunA-3gbfA:
21.43