SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 117
SER A 269
ALA A 270
THR A  92
ILE A  96
 PRP  A 401 (-3.2A)
None
None
PRP  A 401 (-4.2A)
None
 0.98A 1gtnL-3gbrA:
undetectable
1gtnV-3gbrA:
undetectable		 1gtnL-3gbrA:
14.29
1gtnV-3gbrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		3 / 3 THR A 249
GLU A 286
ASP A 281
 None
 0.85A 1nt2A-3gbrA:
2.8		 1nt2A-3gbrA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 7 GLU A 282
GLU A 286
ILE A 253
LEU A 261
 None
 1.39A 1q0yH-3gbrA:
undetectable
1q0yL-3gbrA:
undetectable		 1q0yH-3gbrA:
18.16
1q0yL-3gbrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 THR A  92
ILE A  96
GLY A 117
SER A 269
ALA A 270
 PRP  A 401 (-4.2A)
None
PRP  A 401 (-3.2A)
None
None
 1.01A 1utdL-3gbrA:
undetectable
1utdM-3gbrA:
undetectable		 1utdL-3gbrA:
14.29
1utdM-3gbrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 THR A  92
ILE A  96
GLY A 117
SER A 269
ALA A 270
 PRP  A 401 (-4.2A)
None
PRP  A 401 (-3.2A)
None
None
 0.99A 1utdO-3gbrA:
undetectable
1utdP-3gbrA:
undetectable		 1utdO-3gbrA:
14.29
1utdP-3gbrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 11 THR A  92
ILE A  96
GLY A 117
SER A 269
ALA A 270
 PRP  A 401 (-4.2A)
None
PRP  A 401 (-3.2A)
None
None
 1.01A 1utdP-3gbrA:
undetectable
1utdQ-3gbrA:
undetectable		 1utdP-3gbrA:
14.29
1utdQ-3gbrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 5 VAL A 140
ASN A 141
VAL A  71
ILE A  69
 None
 1.05A 1z2bC-3gbrA:
2.6		 1z2bC-3gbrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 7 ASP A 268
SER A 265
SER A 116
ASN A  89
 None
None
None
PRP  A 401 (-4.1A)
 0.88A 2cmlA-3gbrA:
undetectable		 2cmlA-3gbrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 268
SER A 265
SER A 116
ASN A  89
 None
None
None
PRP  A 401 (-4.1A)
 0.89A 2cmlC-3gbrA:
undetectable		 2cmlC-3gbrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		3 / 3 ARG A  46
GLY A  49
SER A 204
 None
 0.60A 2xctB-3gbrA:
undetectable		 2xctB-3gbrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 9 HIS A 154
ASN A 109
HIS A 107
GLY A 108
THR A 180
 None
 1.20A 3gn0A-3gbrA:
2.4		 3gn0A-3gbrA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 9 HIS A 154
ASN A 109
HIS A 107
GLY A 108
THR A 180
 None
 1.23A 3gn0B-3gbrA:
2.4		 3gn0B-3gbrA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 208
GLY A 177
ASP A  76
GLY A 191
VAL A 192
 None
 0.93A 3oxvC-3gbrA:
undetectable		 3oxvC-3gbrA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 8 ILE A  29
ALA A  66
LEU A  65
PRO A 182
 None
 0.63A 3ozwA-3gbrA:
2.6		 3ozwA-3gbrA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 6 VAL A 160
MET A 157
VAL A  33
PHE A  58
 None
 0.95A 3soaA-3gbrA:
undetectable		 3soaA-3gbrA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 6 ILE A  28
ILE A   6
PHE A  58
LEU A  45
 None
 0.97A 4m51A-3gbrA:
undetectable		 4m51A-3gbrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 176
GLY A 177
MET A 190
VAL A 192
ARG A 170
 None
 1.25A 4olmA-3gbrA:
undetectable		 4olmA-3gbrA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 196
VAL A 192
LEU A 201
 None
 0.62A 5e5jB-3gbrA:
undetectable		 5e5jB-3gbrA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A  76
SER A  99
PHE A 145
LEU A 122
TYR A 127
 None
 1.49A 5ef8B-3gbrA:
2.1		 5ef8B-3gbrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  86
GLY A  82
GLU A 224
ASP A 268
ILE A 262
 None
None
MN  A 502 (-2.5A)
None
None
 1.00A 5ehiC-3gbrA:
undetectable		 5ehiC-3gbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 214
VAL A 216
THR A 231
ASN A 247
ASP A 250
 None
 1.05A 5lg3E-3gbrA:
undetectable		 5lg3E-3gbrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A 216
THR A 231
ASN A 247
ASP A 250
ALA A 293
 None
 0.94A 5lg3E-3gbrA:
undetectable		 5lg3E-3gbrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 214
VAL A 216
THR A 231
ASN A 247
ASP A 250
 None
 1.00A 5lg3J-3gbrA:
undetectable		 5lg3J-3gbrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 11 VAL A 284
ILE A 288
ASN A 291
THR A 292
ILE A 273
 None
 0.87A 5y80A-3gbrA:
undetectable		 5y80A-3gbrA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 7 GLY A  82
GLY A  83
GLY A 221
PRO A 220
GLY A 218
 None
 1.01A 6ag0A-3gbrA:
undetectable		 6ag0A-3gbrA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 209
ASP A  70
ASN A 141
 None
 0.84A 6gngB-3gbrA:
3.8		 6gngB-3gbrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 6 GLY A 177
LEU A 179
VAL A 160
PHE A  58
 None
 0.83A 6h7lA-3gbrA:
undetectable		 6h7lA-3gbrA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 6 GLY A 177
LEU A 179
VAL A 160
PHE A  58
 None
 0.83A 6h7lB-3gbrA:
undetectable		 6h7lB-3gbrA:
14.20