SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gbv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		4 / 6 VAL A 303
THR A 302
GLU A 300
LEU A 298
 None
 0.98A 1s8fB-3gbvA:
2.2		 1s8fB-3gbvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		5 / 11 LEU A 275
LEU A 285
SER A 304
LEU A 188
VAL A 258
 None
 1.31A 2po5B-3gbvA:
3.4		 2po5B-3gbvA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		5 / 11 ILE A 123
PHE A 143
THR A 105
PRO A  73
VAL A 122
 None
 1.09A 2w3aA-3gbvA:
3.2		 2w3aA-3gbvA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		5 / 11 PHE A 283
LEU A 232
PHE A 252
PHE A 198
LEU A 185
 None
 1.34A 3a9eB-3gbvA:
undetectable		 3a9eB-3gbvA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		5 / 9 ILE A 157
ILE A 155
VAL A  84
ILE A 319
ILE A  88
 None
 1.16A 3p4wB-3gbvA:
undetectable		 3p4wB-3gbvA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		5 / 10 ILE A 157
ILE A 155
VAL A  84
ILE A 319
ILE A  88
 None
 1.17A 3p4wD-3gbvA:
undetectable		 3p4wD-3gbvA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		5 / 10 ILE A 157
ILE A 155
VAL A  84
ILE A 319
ILE A  88
 None
 1.15A 3p4wE-3gbvA:
undetectable		 3p4wE-3gbvA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		4 / 5 TYR A  80
SER A 208
ASP A 341
ILE A 340
 EDO  A 363 (-3.5A)
None
None
None
 1.20A 3uj7B-3gbvA:
2.5		 3uj7B-3gbvA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		5 / 10 ILE A 262
VAL A 268
PHE A 264
ILE A 206
ILE A 197
 None
 1.39A 3um5A-3gbvA:
3.2		 3um5A-3gbvA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		5 / 10 ILE A 262
VAL A 268
PHE A 264
ILE A 206
ILE A 197
 None
 1.37A 3um5B-3gbvA:
2.6		 3um5B-3gbvA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		4 / 8 ASP A 163
GLY A 142
THR A 140
ASN A 148
 None
None
EDO  A 362 (-4.2A)
None
 0.96A 5hwaA-3gbvA:
undetectable		 5hwaA-3gbvA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bacteroides
fragilis) 		3 / 3 SER A 174
SER A 177
PHE A 169
 None
 0.96A 5mugA-3gbvA:
undetectable		 5mugA-3gbvA:
22.22