SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gbw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Mus
musculus) 		5 / 11 SER A1250
VAL A1304
LEU A1305
ALA A1306
LEU A1269
 None
 1.07A 1jinA-3gbwA:
undetectable		 1jinA-3gbwA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Mus
musculus) 		3 / 3 HIS A1347
ASP A1373
ASN A1370
 None
 0.87A 1wg8B-3gbwA:
undetectable		 1wg8B-3gbwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Mus
musculus) 		3 / 3 TYR A1307
TYR A1246
GLY A1271
 None
 0.72A 3eteB-3gbwA:
undetectable
3eteD-3gbwA:
undetectable
3eteF-3gbwA:
undetectable		 3eteB-3gbwA:
16.97
3eteD-3gbwA:
16.97
3eteF-3gbwA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Mus
musculus) 		4 / 6 PHE A1256
ALA A1333
GLY A1266
LEU A1282
 None
 0.87A 4dubB-3gbwA:
undetectable		 4dubB-3gbwA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Mus
musculus) 		4 / 7 ARG A1255
GLY A1289
TYR A1331
GLY A1286
 None
 0.83A 4rdxA-3gbwA:
undetectable		 4rdxA-3gbwA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Mus
musculus) 		3 / 3 ALA A1306
TYR A1307
PRO A1340
 None
 0.71A 4zdyA-3gbwA:
undetectable		 4zdyA-3gbwA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Mus
musculus) 		3 / 3 ASP A1343
ASN A1235
GLN A1381
 None
 0.78A 5k7uA-3gbwA:
undetectable		 5k7uA-3gbwA:
20.25