SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		5 / 11 ILE A 121
LEU A 120
MET A 281
LEU A 266
LEU A 211
 None
 0.99A 1dtlA-3gbzA:
undetectable		 1dtlA-3gbzA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		6 / 9 LEU A  21
VAL A  29
LYS A  44
LEU A  77
LEU A  89
LEU A 162
 None
 1.10A 1xkkA-3gbzA:
18.1		 1xkkA-3gbzA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		5 / 10 LEU A  21
ALA A  42
ILE A  75
ASP A  97
LEU A 143
 None
 0.96A 1yi4A-3gbzA:
23.0		 1yi4A-3gbzA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		4 / 8 LEU A 277
TYR A 300
ILE A 121
ILE A 203
 None
 0.79A 2bu8A-3gbzA:
undetectable		 2bu8A-3gbzA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		3 / 3 LYS A 152
ARG A 111
VAL A 112
 None
 0.99A 2r2vC-3gbzA:
undetectable
2r2vD-3gbzA:
undetectable		 2r2vC-3gbzA:
12.21
2r2vD-3gbzA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		5 / 12 ALA A 165
LEU A  66
ILE A 157
LEU A 137
TYR A  26
 None
 1.11A 2w3bB-3gbzA:
undetectable		 2w3bB-3gbzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		5 / 12 ALA A 165
LEU A  66
ILE A 157
LEU A 137
TYR A  26
 None
 1.07A 2w3mA-3gbzA:
undetectable		 2w3mA-3gbzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		4 / 8 LEU A  89
VAL A  29
TYR A  26
LEU A  87
 None
 1.07A 3v81A-3gbzA:
undetectable		 3v81A-3gbzA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		6 / 12 LYS A  44
ASP A 136
LYS A 138
ASN A 141
ASP A 159
GLY A 161
 None
 1.25A 4an2A-3gbzA:
24.5		 4an2A-3gbzA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		6 / 12 LYS A  44
LEU A  66
ASP A 136
LYS A 138
ASN A 141
ASP A 159
 None
 1.36A 4an2A-3gbzA:
24.5		 4an2A-3gbzA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		4 / 5 VAL A  29
ILE A  74
TYR A  93
ILE A 157
 None
 0.61A 4c8bA-3gbzA:
22.4		 4c8bA-3gbzA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		6 / 11 LEU A  21
GLY A  22
GLY A  24
VAL A  29
ALA A  42
TYR A  93
 None
 0.74A 4ckiA-3gbzA:
12.3		 4ckiA-3gbzA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		7 / 11 LEU A  21
GLY A  24
VAL A  29
ALA A  42
TYR A  93
ALA A  94
LEU A 143
 None
 0.95A 4ckiA-3gbzA:
12.3		 4ckiA-3gbzA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		5 / 12 ALA A 165
LEU A  66
ILE A 157
LEU A 137
TYR A  26
 None
 1.06A 4kebB-3gbzA:
undetectable		 4kebB-3gbzA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		5 / 12 ALA A 165
LEU A  66
ILE A 157
LEU A 137
TYR A  26
 None
 1.07A 4kfjB-3gbzA:
undetectable		 4kfjB-3gbzA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		4 / 6 LEU A  21
VAL A  29
ARG A 135
ILE A 157
 None
 0.70A 4tyjA-3gbzA:
21.8		 4tyjA-3gbzA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		4 / 7 VAL A  29
ALA A  94
ARG A 135
ILE A 157
 None
 0.86A 4uxqA-3gbzA:
18.4		 4uxqA-3gbzA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		6 / 9 VAL A  29
ILE A  75
CYH A 132
ARG A 135
LEU A 143
ILE A 157
 None
 0.92A 4v01A-3gbzA:
16.6		 4v01A-3gbzA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		6 / 9 VAL A  29
ILE A  75
TYR A  93
ARG A 135
LEU A 143
ILE A 157
 None
 0.94A 4v01A-3gbzA:
16.6		 4v01A-3gbzA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		4 / 8 ILE A  75
TYR A  93
LEU A 143
ILE A 157
 None
 0.65A 4v04A-3gbzA:
21.8		 4v04A-3gbzA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		5 / 12 GLY A 274
LEU A 120
PHE A 160
ILE A  74
LEU A 296
 None
 1.09A 4ze2A-3gbzA:
undetectable		 4ze2A-3gbzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		5 / 12 LEU A 275
LEU A 282
LEU A 266
THR A 214
ALA A 204
 None
 1.10A 5eypB-3gbzA:
undetectable		 5eypB-3gbzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		6 / 12 LEU A  21
VAL A  29
ALA A  42
LYS A  44
LEU A 143
GLY A 158
 None
 0.68A 5h2uA-3gbzA:
20.3		 5h2uA-3gbzA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		7 / 12 LEU A  21
VAL A  29
ALA A  42
LYS A  44
LEU A 143
GLY A 158
ASP A 159
 None
 0.66A 5h2uB-3gbzA:
20.7		 5h2uB-3gbzA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		5 / 12 VAL A  29
ALA A  42
ILE A  75
TYR A  93
ALA A  94
 None
 0.56A 5hesA-3gbzA:
23.7		 5hesA-3gbzA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		4 / 5 TYR A  30
LYS A  20
GLU A  23
GLY A  27
 None
 0.66A 5jhdJ-3gbzA:
undetectable		 5jhdJ-3gbzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		3 / 3 LYS A 251
TRP A 250
SER A 253
 None
 1.21A 5nwwA-3gbzA:
undetectable		 5nwwA-3gbzA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		5 / 12 LEU A 275
LEU A 282
LEU A 266
THR A 214
ALA A 204
 None
 1.12A 5xiwD-3gbzA:
undetectable		 5xiwD-3gbzA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3gbz KINASE, CMGC CDK
(Giardia
intestinalis) 		6 / 12 LEU A  21
VAL A  29
ALA A  42
LEU A  89
LEU A 143
ASP A 159
 None
 0.56A 5yu9A-3gbzA:
24.1		 5yu9A-3gbzA:
14.59