SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		4 / 7 GLY A  41
TYR A  31
ALA A  90
GLU A  44
 SIN  A 401 ( 4.7A)
None
None
None
 0.78A 1dmaA-3gc2A:
undetectable		 1dmaA-3gc2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 12 ALA A  92
GLU A  93
LEU A  91
ARG A 301
ILE A 261
 None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-3.2A)
None
 1.21A 1errA-3gc2A:
undetectable		 1errA-3gc2A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 12 ALA A  90
LEU A  91
LEU A  34
LEU A  63
LEU A  77
 None
 1.22A 1errB-3gc2A:
undetectable		 1errB-3gc2A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 9 ALA A 175
ILE A 186
VAL A 146
ILE A 210
ILE A 208
 None
 0.85A 1hshB-3gc2A:
undetectable		 1hshB-3gc2A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 11 VAL A  67
LEU A  71
TYR A   7
LEU A 320
GLN A   5
 None
 1.05A 1rlbF-3gc2A:
undetectable		 1rlbF-3gc2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 12 LEU A 109
GLY A 288
VAL A 260
LEU A 158
ILE A 129
 None
SIN  A 400 (-3.2A)
None
None
EPE  A 402 (-4.4A)
 1.38A 3h52A-3gc2A:
undetectable		 3h52A-3gc2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		4 / 4 ARG A 246
ASP A 213
GLY A 288
THR A 282
 None
NA  A 321 (-3.3A)
SIN  A 400 (-3.2A)
None
 1.25A 3k4vB-3gc2A:
undetectable		 3k4vB-3gc2A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 9 SER A 263
ILE A 277
ALA A 278
THR A 282
ALA A 259
 SIN  A 400 (-4.9A)
None
None
None
None
 1.26A 3mdtA-3gc2A:
undetectable		 3mdtA-3gc2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 11 ALA A  92
GLY A  43
LEU A  77
PRO A 236
LEU A 242
 None
 1.02A 3sm2B-3gc2A:
undetectable		 3sm2B-3gc2A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 VAL A 178
LEU A 160
VAL A 134
PHE A 174
 None
 0.97A 4lb0B-3gc2A:
undetectable		 4lb0B-3gc2A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 12 LEU A 109
ALA A 130
LEU A 149
LEU A 158
LEU A 121
 None
 1.16A 4zn7A-3gc2A:
undetectable		 4zn7A-3gc2A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		4 / 7 GLY A  41
GLY A  43
PHE A  85
LEU A 242
 SIN  A 401 ( 4.7A)
None
None
None
 0.80A 5izfA-3gc2A:
undetectable		 5izfA-3gc2A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 9 ALA A 275
ALA A 279
ALA A 102
GLY A 288
ALA A 106
 None
None
None
SIN  A 400 (-3.2A)
None
 1.01A 5l5zK-3gc2A:
undetectable
5l5zL-3gc2A:
undetectable		 5l5zK-3gc2A:
20.54
5l5zL-3gc2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 9 ALA A 275
ALA A 279
ALA A 102
GLY A 288
ALA A 106
 None
None
None
SIN  A 400 (-3.2A)
None
 1.01A 5l5zY-3gc2A:
undetectable
5l5zZ-3gc2A:
undetectable		 5l5zY-3gc2A:
20.54
5l5zZ-3gc2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		5 / 12 ALA A 107
LEU A 121
VAL A 132
ASP A 113
THR A 111
 None
 1.34A 5vlmD-3gc2A:
undetectable		 5vlmD-3gc2A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 LEU A 149
THR A 111
ARG A 159
ARG A 105
 None
None
EPE  A 402 (-3.8A)
None
 1.15A 6ew0B-3gc2A:
undetectable		 6ew0B-3gc2A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 LEU A 149
THR A 111
ARG A 159
ARG A 105
 None
None
EPE  A 402 (-3.8A)
None
 1.15A 6ew0D-3gc2A:
undetectable		 6ew0D-3gc2A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 LEU A 149
THR A 111
ARG A 159
ARG A 105
 None
None
EPE  A 402 (-3.8A)
None
 1.15A 6ew0H-3gc2A:
undetectable		 6ew0H-3gc2A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3gc2 O-SUCCINYLBENZOATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 LEU A 149
THR A 111
ARG A 159
ARG A 105
 None
None
EPE  A 402 (-3.8A)
None
 1.15A 6ew0I-3gc2A:
undetectable		 6ew0I-3gc2A:
15.55