SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 3gc3 BETA-ARRESTIN-1
(Bos
taurus) 		5 / 12 LEU A 343
VAL A 253
TYR A 238
VAL A 319
LEU A 129
 None
 0.99A 1s19A-3gc3A:
undetectable		 1s19A-3gc3A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 3gc3 BETA-ARRESTIN-1
(Bos
taurus) 		5 / 12 SER A 193
LEU A 199
ASP A 334
GLY A 333
VAL A 228
 None
 1.25A 2kceA-3gc3A:
undetectable		 2kceA-3gc3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3gc3 BETA-ARRESTIN-1
(Bos
taurus) 		3 / 3 THR A  56
VAL A  81
GLU A 145
 None
 0.70A 3v4tA-3gc3A:
undetectable
3v4tD-3gc3A:
undetectable		 3v4tA-3gc3A:
24.78
3v4tD-3gc3A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3gc3 BETA-ARRESTIN-1
(Bos
taurus) 		5 / 12 GLY A 141
VAL A 127
THR A 128
LEU A 129
TYR A  63
 None
 1.22A 4f84A-3gc3A:
undetectable		 4f84A-3gc3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 3gc3 BETA-ARRESTIN-1
(Bos
taurus) 		4 / 5 ASP A  26
VAL A  37
ASP A  38
GLY A  23
 None
 1.16A 4xp6A-3gc3A:
undetectable		 4xp6A-3gc3A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3gc3 BETA-ARRESTIN-1
(Bos
taurus) 		4 / 6 PHE A 117
PRO A  36
VAL A  37
THR A  98
 None
 0.74A 5t7bA-3gc3A:
undetectable		 5t7bA-3gc3A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3gc3 BETA-ARRESTIN-1
(Bos
taurus) 		3 / 3 HIS A 210
SER A 302
ARG A 169
 None
 0.98A 5u63A-3gc3A:
undetectable		 5u63A-3gc3A:
22.77