SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gcf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		5 / 10 ILE A 293
ASN A 176
LEU A  55
GLY A  56
ALA A  27
 CL  A 396 ( 4.9A)
None
None
None
None
 1.41A 1ju6C-3gcfA:
undetectable		 1ju6C-3gcfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		5 / 11 ILE A 293
ASN A 176
LEU A  55
GLY A  56
ALA A  27
 CL  A 396 ( 4.9A)
None
None
None
None
 1.42A 1ju6D-3gcfA:
undetectable		 1ju6D-3gcfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 6 VAL A 250
THR A 249
GLU A 242
LEU A 251
 None
 1.08A 1s8fB-3gcfA:
undetectable		 1s8fB-3gcfA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		5 / 12 GLU A 299
PHE A  40
VAL A 338
VAL A 173
HIS A 298
 CL  A 396 ( 4.0A)
None
None
None
None
 1.47A 1x70A-3gcfA:
undetectable		 1x70A-3gcfA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		5 / 12 ILE A 190
VAL A 276
LEU A 274
ALA A 329
PHE A 333
 None
 1.18A 2jj8C-3gcfA:
undetectable		 2jj8C-3gcfA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		5 / 12 ARG A 381
ILE A 143
GLY A  74
LEU A 105
VAL A  52
 None
None
None
None
CL  A 396 ( 4.6A)
 1.45A 2nyrB-3gcfA:
undetectable		 2nyrB-3gcfA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 6 VAL A 121
PRO A 117
THR A 115
TRP A 101
 None
None
None
FES  A 401 (-4.1A)
 1.16A 2q6oB-3gcfA:
undetectable		 2q6oB-3gcfA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		5 / 12 GLU A  57
PHE A 142
GLU A 146
ASP A 154
GLY A 379
 None
None
None
None
CL  A 395 ( 4.3A)
 1.09A 3jzjA-3gcfA:
undetectable		 3jzjA-3gcfA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 5 LEU A  55
ALA A  27
PHE A  31
ASN A 176
 None
 1.28A 3uq6A-3gcfA:
undetectable		 3uq6A-3gcfA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 4 LEU A  55
ALA A  27
PHE A  31
ASN A 176
 None
 1.24A 3vaqA-3gcfA:
undetectable		 3vaqA-3gcfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 4 LEU A  55
ALA A  27
PHE A  31
ASN A 176
 None
 1.24A 3vasA-3gcfA:
undetectable		 3vasA-3gcfA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		5 / 10 ALA A  64
LEU A  60
LEU A 105
ASP A 106
ILE A  71
 None
 1.16A 3wdmB-3gcfA:
undetectable		 3wdmB-3gcfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		5 / 10 ALA A  64
LEU A  60
LEU A 105
ASP A 106
ILE A  71
 None
 1.08A 3wdmD-3gcfA:
undetectable		 3wdmD-3gcfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 5 LEU A 330
ASP A 328
ARG A 324
TRP A 325
 None
 1.44A 4mwrA-3gcfA:
undetectable		 4mwrA-3gcfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 5 ILE A 366
ASP A 337
GLU A 182
VAL A 268
 None
FE2  A 501 (-1.9A)
None
None
 1.19A 4nkxC-3gcfA:
undetectable		 4nkxC-3gcfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 5 ILE A 366
ASP A 337
GLU A 182
VAL A 268
 None
FE2  A 501 (-1.9A)
None
None
 1.20A 4nkxD-3gcfA:
undetectable		 4nkxD-3gcfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 4 THR A  53
ARG A 170
GLU A 299
VAL A  52
 None
None
CL  A 396 ( 4.0A)
CL  A 396 ( 4.6A)
 1.30A 4odoC-3gcfA:
undetectable		 4odoC-3gcfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 6 LEU A 330
ASN A 334
LEU A 284
VAL A 262
 None
 1.16A 4okbA-3gcfA:
undetectable		 4okbA-3gcfA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 6 ASP A 154
GLY A 377
VAL A 380
HIS A  36
 None
None
CL  A 395 ( 4.5A)
None
 1.07A 4oltB-3gcfA:
undetectable		 4oltB-3gcfA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		3 / 3 PRO A 156
LEU A 155
GLN A 136
 None
 0.73A 4pevB-3gcfA:
undetectable		 4pevB-3gcfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		3 / 3 ARG A 178
GLU A 357
TYR A  24
 None
 0.89A 4r29D-3gcfA:
undetectable		 4r29D-3gcfA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 7 LEU A 284
PHE A 279
LEU A 304
PHE A 321
 None
 0.99A 5b3sC-3gcfA:
undetectable
5b3sJ-3gcfA:
undetectable		 5b3sC-3gcfA:
18.91
5b3sJ-3gcfA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		4 / 5 LEU A 284
PHE A 279
LEU A 304
PHE A 321
 None
 1.06A 5xdxP-3gcfA:
undetectable
5xdxW-3gcfA:
undetectable		 5xdxP-3gcfA:
18.75
5xdxW-3gcfA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		5 / 12 LEU A 179
GLY A 180
HIS A 298
VAL A 229
VAL A 268
 None
 1.26A 6bxlB-3gcfA:
undetectable		 6bxlB-3gcfA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Nocardioides
aromaticivorans) 		3 / 3 ARG A 306
LEU A 284
PHE A 279
 None
 0.76A 6nknP-3gcfA:
undetectable		 6nknP-3gcfA:
18.91