SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 ASN A 354
THR A 339
ASP A 367
GLY A 337
 None
 0.77A 1bu5B-3gcwA:
3.0		 1bu5B-3gcwA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 10 ALA A 388
SER A 419
ILE A 416
ILE A 334
THR A 385
 None
 1.24A 1j3jA-3gcwA:
undetectable		 1j3jA-3gcwA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 7 LEU A 348
LEU A 351
PHE A 318
ALA A 315
 None
 0.62A 1j8uA-3gcwA:
undetectable		 1j8uA-3gcwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 387
THR A 385
GLY A 365
GLY A 240
ALA A 390
 None
 1.11A 1jg4A-3gcwA:
undetectable		 1jg4A-3gcwA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLY A 316
ASP A 320
ALA A 388
SER A 386
LEU A 361
 None
 1.39A 1kiaD-3gcwA:
undetectable		 1kiaD-3gcwA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 HIS A 391
ALA A 363
PHE A 362
GLY A 365
 None
 1.25A 1mj2B-3gcwA:
undetectable		 1mj2B-3gcwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 HIS A 391
ALA A 363
PHE A 362
GLY A 365
 None
 1.26A 1mj2D-3gcwA:
undetectable		 1mj2D-3gcwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 HIS A 391
ALA A 363
PHE A 362
GLY A 365
 None
 1.24A 1mjoB-3gcwA:
undetectable		 1mjoB-3gcwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 HIS A 391
ALA A 363
PHE A 362
GLY A 365
 None
 1.19A 1mjoA-3gcwA:
undetectable		 1mjoA-3gcwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 HIS A 391
ALA A 363
PHE A 362
GLY A 365
 None
 1.25A 1mjoD-3gcwA:
undetectable		 1mjoD-3gcwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 10 LEU A 230
ALA A 290
ALA A 314
VAL A 233
GLN A 382
 None
 1.31A 1rlbE-3gcwA:
undetectable		 1rlbE-3gcwA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 PHE A 318
ASN A 354
SER A 386
ALA A 322
 None
 1.09A 1rqpC-3gcwA:
2.3		 1rqpC-3gcwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 PHE A 318
ASN A 354
SER A 386
ALA A 322
 None
 1.09A 1rqpA-3gcwA:
2.8		 1rqpA-3gcwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 7 PHE A 270
LEU A 287
PHE A 205
MET A 201
 None
 1.09A 1wrlE-3gcwA:
undetectable		 1wrlE-3gcwA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 VAL A 312
VAL A 336
LEU A 286
HIS A 391
 None
 0.99A 2ddwA-3gcwA:
3.0		 2ddwA-3gcwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 TYR A 183
ARG A 248
PHE A 270
VAL A 285
 None
 0.89A 2fl5E-3gcwA:
undetectable
2fl5F-3gcwA:
undetectable		 2fl5E-3gcwA:
17.96
2fl5F-3gcwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 PHE A 318
ASN A 354
SER A 386
ALA A 322
 None
 1.11A 2v7uA-3gcwA:
5.8		 2v7uA-3gcwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		3 / 3 ARG A 495
GLU A 620
SER A 487
 None
 0.88A 2xkkA-3gcwA:
undetectable
2xkkC-3gcwA:
undetectable		 2xkkA-3gcwA:
21.62
2xkkC-3gcwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 GLN A 382
GLN A 190
ASP A 374
SER A 221
 None
 1.23A 2xz5C-3gcwA:
undetectable
2xz5D-3gcwA:
undetectable		 2xz5C-3gcwA:
15.80
2xz5D-3gcwA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 THR A 385
GLY A 337
LEU A 268
PRO A 327
THR A 264
 None
 0.96A 2y7hC-3gcwA:
undetectable		 2y7hC-3gcwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 5 VAL A 182
VAL A 284
GLN A 275
ARG A 272
 None
 1.40A 3bjwB-3gcwA:
0.7		 3bjwB-3gcwA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 6 VAL A 336
LEU A 436
ILE A 395
ILE A 334
 None
 0.95A 3gcsA-3gcwA:
undetectable		 3gcsA-3gcwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLY A 352
TRP A 428
THR A 437
VAL A 359
PHE A 362
 None
 1.34A 3gn8B-3gcwA:
undetectable		 3gn8B-3gcwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
 None
 1.04A 3keeB-3gcwA:
undetectable		 3keeB-3gcwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 0.94A 3keeB-3gcwA:
undetectable		 3keeB-3gcwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 4 GLN A 433
PHE A 355
TYR A 325
LEU A 440
 None
 1.45A 3keeC-3gcwA:
0.0		 3keeC-3gcwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
 None
 1.10A 3keeD-3gcwA:
undetectable		 3keeD-3gcwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 0.96A 3keeD-3gcwA:
undetectable		 3keeD-3gcwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 VAL A 284
PRO A 282
ALA A 409
LEU A 415
ILE A 334
 None
 0.84A 3ku1A-3gcwA:
2.2		 3ku1A-3gcwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 VAL A 284
PRO A 282
ALA A 409
LEU A 415
ILE A 334
 None
 0.84A 3ku1C-3gcwA:
2.7		 3ku1C-3gcwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 VAL A 284
PRO A 282
ALA A 409
LEU A 415
ILE A 334
 None
 0.80A 3ku1G-3gcwA:
2.2		 3ku1G-3gcwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 VAL A 284
PRO A 282
ALA A 409
LEU A 415
ILE A 334
 None
 0.82A 3ku1H-3gcwA:
2.7		 3ku1H-3gcwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 LEU A 297
ALA A 315
THR A 313
GLY A 259
 None
 0.93A 3ny4A-3gcwA:
undetectable		 3ny4A-3gcwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
 None
 1.07A 3sudA-3gcwA:
undetectable		 3sudA-3gcwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		6 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
 None
 1.40A 3sueA-3gcwA:
undetectable		 3sueA-3gcwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
 None
 1.15A 3sueB-3gcwA:
undetectable		 3sueB-3gcwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 0.97A 3sueB-3gcwA:
undetectable		 3sueB-3gcwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		6 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
 None
 1.42A 3sueC-3gcwA:
undetectable		 3sueC-3gcwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 0.93A 3sueD-3gcwA:
undetectable		 3sueD-3gcwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
 None
 0.97A 3sufA-3gcwA:
undetectable		 3sufA-3gcwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 0.91A 3sufA-3gcwA:
undetectable		 3sufA-3gcwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 11 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 0.95A 3sufC-3gcwA:
undetectable		 3sufC-3gcwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
 None
 0.82A 3sufD-3gcwA:
undetectable		 3sufD-3gcwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 5 HIS A 193
GLN A 190
SER A 191
VAL A 200
 None
 1.35A 4a99D-3gcwA:
undetectable		 4a99D-3gcwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 7 GLY A 337
THR A 339
ILE A 424
PHE A 429
 None
 0.84A 4ejjA-3gcwA:
undetectable		 4ejjA-3gcwA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 7 GLY A 337
THR A 339
ILE A 424
PHE A 429
 None
 0.85A 4ejjD-3gcwA:
undetectable		 4ejjD-3gcwA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 LEU A 415
ALA A 393
ALA A 388
GLY A 365
ALA A 442
 None
 1.16A 4enhA-3gcwA:
undetectable		 4enhA-3gcwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 6 ASP A 360
GLY A 356
PRO A 345
THR A 339
 None
 1.10A 4l1aB-3gcwA:
undetectable		 4l1aB-3gcwA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 MET A 398
VAL A 284
VAL A 233
GLY A 232
 None
 1.01A 4mk4A-3gcwA:
2.4		 4mk4A-3gcwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 ALA A 442
GLY A 365
ALA A 388
ILE A 395
VAL A 233
 None
 0.94A 4nkxB-3gcwA:
undetectable		 4nkxB-3gcwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 7 LEU A 289
THR A 335
ALA A 314
THR A 385
 None
 1.04A 4pwjB-3gcwA:
undetectable		 4pwjB-3gcwA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 9 ALA A 314
THR A 313
ALA A 389
GLY A 291
ASP A 186
 None
 1.16A 4qwuK-3gcwA:
undetectable
4qwuL-3gcwA:
undetectable		 4qwuK-3gcwA:
17.78
4qwuL-3gcwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 VAL A 310
LEU A 411
VAL A 392
GLY A 394
ALA A 393
 None
 1.20A 4rrwB-3gcwA:
undetectable		 4rrwB-3gcwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 VAL A 310
LEU A 411
VAL A 392
GLY A 394
ALA A 393
 None
 1.20A 4rrzB-3gcwA:
undetectable		 4rrzB-3gcwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 TYR A 648
SER A 487
THR A 623
ALA A 674
ALA A 637
 None
 1.41A 4u15A-3gcwA:
undetectable		 4u15A-3gcwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 5 ALA A 363
THR A 339
VAL A 423
ILE A 424
 None
 0.95A 4xe3B-3gcwA:
undetectable		 4xe3B-3gcwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 12 LEU A 230
VAL A 233
LEU A 415
VAL A 312
VAL A 310
 None
 0.95A 4y0qA-3gcwA:
undetectable		 4y0qA-3gcwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		3 / 3 THR A 335
HIS A 464
LEU A 436
 None
 0.73A 5axdA-3gcwA:
3.2		 5axdA-3gcwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		3 / 3 THR A 335
HIS A 464
LEU A 436
 None
 0.74A 5axdC-3gcwA:
undetectable		 5axdC-3gcwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 7 LEU A 289
THR A 335
ALA A 314
THR A 385
 None
 1.03A 5bojB-3gcwA:
undetectable		 5bojB-3gcwA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 THR A 437
GLY A 337
ALA A 322
THR A 353
 None
 0.97A 5eevL-3gcwA:
undetectable
5eevV-3gcwA:
undetectable		 5eevL-3gcwA:
7.93
5eevV-3gcwA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 THR A 437
GLY A 337
ALA A 322
THR A 353
 None
 0.97A 5eewL-3gcwA:
undetectable
5eewV-3gcwA:
undetectable		 5eewL-3gcwA:
7.93
5eewV-3gcwA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 8 THR A 437
GLY A 337
ALA A 322
THR A 353
 None
 0.96A 5ef3L-3gcwA:
undetectable
5ef3V-3gcwA:
undetectable		 5ef3L-3gcwA:
7.93
5ef3V-3gcwA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		6 / 12 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
 None
 1.20A 6c2mC-3gcwA:
undetectable		 6c2mC-3gcwA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 9 VAL A 234
HIS A 391
GLY A 394
ILE A 271
ASP A 186
 None
 1.32A 6c2mC-3gcwA:
undetectable		 6c2mC-3gcwA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		3 / 3 LEU A 484
ASP A 651
ILE A 416
 None
 0.48A 6dh0B-3gcwA:
undetectable		 6dh0B-3gcwA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		4 / 5 ARG A 160
ALA A 420
GLN A 344
ILE A 424
 None
 1.25A 6g9bA-3gcwA:
undetectable
6g9bB-3gcwA:
0.4		 6g9bA-3gcwA:
9.96
6g9bB-3gcwA:
10.75