SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3gcz POLYPROTEIN
(Yokose
virus) 		6 / 12 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
LYS A 183
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
SAM  A4633 ( 4.8A)
 0.66A 1eizA-3gczA:
15.3		 1eizA-3gczA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
 0.35A 1ej0A-3gczA:
15.1		 1ej0A-3gczA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  81
GLY A  85
TRP A  87
LEU A 105
LYS A 183
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
SAM  A4633 ( 4.8A)
 0.77A 1ej0A-3gczA:
15.1		 1ej0A-3gczA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 9 SER A  59
ARG A  38
LEU A  45
ILE A  53
ASP A 257
 SAM  A4633 ( 4.9A)
SO4  A 268 (-3.9A)
None
None
None
 1.35A 1nb9A-3gczA:
undetectable		 1nb9A-3gczA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 9 THR A 118
ARG A  38
LEU A  45
ILE A  53
ASP A 257
 None
SO4  A 268 (-3.9A)
None
None
None
 1.14A 1nb9A-3gczA:
undetectable		 1nb9A-3gczA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 11 THR A 118
ARG A  38
LEU A  45
ILE A  53
ASP A 257
 None
SO4  A 268 (-3.9A)
None
None
None
 1.10A 1t6zA-3gczA:
undetectable		 1t6zA-3gczA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 11 THR A 118
ARG A  38
LEU A  45
ILE A  53
ASP A 257
 None
SO4  A 268 (-3.9A)
None
None
None
 1.09A 1t6zB-3gczA:
undetectable		 1t6zB-3gczA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 11 VAL A 230
VAL A 234
TYR A 188
LEU A 165
ILE A 192
 None
 1.45A 1t6zB-3gczA:
undetectable		 1t6zB-3gczA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3gcz POLYPROTEIN
(Yokose
virus) 		3 / 3 VAL A 164
TRP A 171
VAL A 132
 None
None
SAM  A4633 (-3.6A)
 0.78A 2izqA-3gczA:
undetectable
2izqB-3gczA:
undetectable		 2izqA-3gczA:
6.09
2izqB-3gczA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  81
GLY A  85
TRP A  87
LEU A 105
VAL A 132
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.6A)
 0.46A 2nyuA-3gczA:
14.8		 2nyuA-3gczA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  85
TRP A  87
LEU A 105
VAL A 132
LYS A 183
 SAM  A4633 ( 4.3A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.6A)
SAM  A4633 ( 4.8A)
 0.76A 2nyuA-3gczA:
14.8		 2nyuA-3gczA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3gcz POLYPROTEIN
(Yokose
virus) 		6 / 12 GLY A  81
GLY A  85
TRP A  87
LEU A 105
VAL A 132
LYS A 183
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.6A)
SAM  A4633 ( 4.8A)
 0.71A 2nyuB-3gczA:
14.7		 2nyuB-3gczA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		7 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
THR A 104
LEU A 105
GLU A 111
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
None
 0.65A 2oxtA-3gczA:
40.6		 2oxtA-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		8 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LEU A 105
ASP A 146
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.7A)
 0.36A 2oxtA-3gczA:
40.6		 2oxtA-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		3 / 3 SER A  56
HIS A 110
ASP A 131
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
 0.28A 2oxtA-3gczA:
40.6		 2oxtA-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		8 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  85
TRP A  87
THR A 104
LEU A 105
GLU A 111
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
None
 0.78A 2oxtB-3gczA:
40.6		 2oxtB-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		8 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  85
TRP A  87
THR A 104
LEU A 105
LYS A 183
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
SAM  A4633 ( 4.8A)
 0.62A 2oxtB-3gczA:
40.6		 2oxtB-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		7 / 12 GLY A  81
GLY A  83
GLY A  85
THR A 104
LEU A 105
GLU A 111
ILE A 147
 SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
None
SAM  A4633 ( 4.2A)
 1.33A 2oxtB-3gczA:
40.6		 2oxtB-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 5 SER A  56
GLY A  86
HIS A 110
ASP A 131
ASP A 146
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.28A 2oxtB-3gczA:
40.6		 2oxtB-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		8 / 12 GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LEU A 105
ASP A 146
LYS A 183
 SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.8A)
 0.47A 2oxtC-3gczA:
40.4		 2oxtC-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		8 / 12 GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LEU A 105
GLU A 111
ASP A 146
 SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
None
SAM  A4633 (-3.7A)
 0.50A 2oxtC-3gczA:
40.4		 2oxtC-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 4 SER A  56
GLY A  58
HIS A 110
ASP A 131
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
 0.31A 2oxtC-3gczA:
40.4		 2oxtC-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
ASP A  79
GLY A  81
GLY A  83
GLY A  86
THR A 104
LEU A 105
HIS A 110
GLU A 111
ASP A 146
 SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.7A)
 0.52A 2oxtD-3gczA:
40.6		 2oxtD-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.31A 2pxcA-3gczA:
40.5		 2pxcA-3gczA:
54.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 10 LEU A 144
VAL A  77
LEU A  62
SER A  59
ALA A  91
 None
None
None
SAM  A4633 ( 4.9A)
None
 0.95A 2v3kA-3gczA:
undetectable		 2v3kA-3gczA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
TRP A  87
THR A 104
LEU A 105
GLU A 111
ASP A 131
VAL A 132
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
None
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 ( 4.2A)
 0.39A 2wa2A-3gczA:
34.3		 2wa2A-3gczA:
51.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
TRP A  87
THR A 104
LEU A 105
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.33A 2wa2B-3gczA:
41.5		 2wa2B-3gczA:
51.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		3 / 3 MET A 193
VAL A 164
GLU A 157
 None
 0.92A 2x9gA-3gczA:
5.3		 2x9gA-3gczA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LEU A 105
 SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.0A)
 0.37A 3douA-3gczA:
14.7		 3douA-3gczA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LEU A 105
VAL A 132
PHE A 133
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.9A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.20A 3eluA-3gczA:
40.6		 3eluA-3gczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LEU A 105
VAL A 132
PHE A 133
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.9A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.18A 3elwA-3gczA:
41.7		 3elwA-3gczA:
55.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LEU A 105
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.28A 3embA-3gczA:
40.8		 3embA-3gczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		12 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LEU A 105
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.00A 3gczA-3gczA:
48.1		 3gczA-3gczA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  81
GLY A  83
GLY A  85
ASP A 131
ASP A 146
 SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.64A 3ihtA-3gczA:
7.5		 3ihtA-3gczA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 3gcz POLYPROTEIN
(Yokose
virus) 		3 / 3 VAL A 132
VAL A 164
TRP A 171
 SAM  A4633 (-3.6A)
None
None
 0.84A 3l8lA-3gczA:
undetectable
3l8lB-3gczA:
undetectable		 3l8lA-3gczA:
6.09
3l8lB-3gczA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 VAL A 132
LEU A  80
CYH A  82
ILE A 124
PHE A 126
 SAM  A4633 (-3.6A)
None
None
None
None
 1.41A 3mnoA-3gczA:
undetectable		 3mnoA-3gczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 LEU A  62
ILE A 124
GLY A 120
ALA A  92
SER A  93
 None
 1.11A 3n8xB-3gczA:
undetectable		 3n8xB-3gczA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 LEU A  62
ILE A 124
GLY A 120
SER A  93
LEU A  94
 None
 1.08A 3n8xB-3gczA:
undetectable		 3n8xB-3gczA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.46A 3p97A-3gczA:
41.3		 3p97A-3gczA:
55.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
None
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.37A 3p97C-3gczA:
40.9		 3p97C-3gczA:
55.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 5 TYR A 177
THR A 178
PHE A 180
LEU A 144
 None
 1.45A 3qelC-3gczA:
2.2		 3qelC-3gczA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 8 GLY A  86
ALA A 102
SER A  88
TYR A  89
 SAM  A4633 (-3.2A)
None
None
None
 0.91A 3u9hA-3gczA:
undetectable		 3u9hA-3gczA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A 148
ILE A 182
CYH A 145
ILE A 147
LEU A 196
 None
None
None
SAM  A4633 ( 4.2A)
None
 1.03A 3uj7B-3gczA:
8.9		 3uj7B-3gczA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 3gcz POLYPROTEIN
(Yokose
virus) 		7 / 12 SER A  56
GLY A  81
GLY A  85
GLY A  86
TRP A  87
ASP A 131
ASP A 146
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.69A 4b17A-3gczA:
13.7		 4b17A-3gczA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 6 ARG A  38
GLU A 255
LEU A 212
ASP A 257
 SO4  A 268 (-3.9A)
None
None
None
 1.24A 4cevA-3gczA:
undetectable
4cevB-3gczA:
undetectable		 4cevA-3gczA:
24.49
4cevB-3gczA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 6 ASP A 257
ARG A  38
GLU A 255
LEU A 212
 None
SO4  A 268 (-3.9A)
None
None
 1.24A 4cevA-3gczA:
undetectable
4cevC-3gczA:
undetectable		 4cevA-3gczA:
24.49
4cevC-3gczA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 6 ARG A  38
GLU A 255
LEU A 212
ASP A 257
 SO4  A 268 (-3.9A)
None
None
None
 1.24A 4cevD-3gczA:
undetectable
4cevE-3gczA:
undetectable		 4cevD-3gczA:
24.49
4cevE-3gczA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 6 ARG A  38
GLU A 255
LEU A 212
ASP A 257
 SO4  A 268 (-3.9A)
None
None
None
 1.25A 4cevE-3gczA:
undetectable
4cevF-3gczA:
undetectable		 4cevE-3gczA:
24.49
4cevF-3gczA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 7 THR A 142
VAL A 100
ASP A  79
VAL A  77
 None
 0.99A 4cp4A-3gczA:
undetectable		 4cp4A-3gczA:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
None
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.42A 4ctjA-3gczA:
41.2		 4ctjA-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.47A 4ctjC-3gczA:
41.0		 4ctjC-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.38A 4ctkA-3gczA:
41.1		 4ctkA-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.32A 4ctkC-3gczA:
40.8		 4ctkC-3gczA:
55.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		3 / 3 ARG A 209
THR A 242
TRP A  13
 None
 1.08A 4d7hA-3gczA:
1.2		 4d7hA-3gczA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 7 GLY A  86
ALA A 102
SER A  88
TYR A  89
 SAM  A4633 (-3.2A)
None
None
None
 0.91A 4hyfA-3gczA:
undetectable		 4hyfA-3gczA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 8 GLY A  86
ALA A 102
SER A  88
TYR A  89
 SAM  A4633 (-3.2A)
None
None
None
 0.90A 4hyfC-3gczA:
undetectable		 4hyfC-3gczA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 SER A  56
ASP A  79
GLY A  81
LEU A 105
ASP A 131
 SAM  A4633 (-2.7A)
None
SAM  A4633 (-3.4A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.7A)
 1.13A 4pghB-3gczA:
8.3		 4pghB-3gczA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  81
GLY A  83
GLY A  85
LEU A 105
LYS A 183
 SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-4.0A)
SAM  A4633 ( 4.8A)
 0.92A 4uciA-3gczA:
10.1		 4uciA-3gczA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  81
GLY A  83
GLY A  85
LEU A 105
LYS A 183
 SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 ( 4.3A)
SAM  A4633 (-4.0A)
SAM  A4633 ( 4.8A)
 0.90A 4uciB-3gczA:
8.3		 4uciB-3gczA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3gcz POLYPROTEIN
(Yokose
virus) 		3 / 3 SER A  56
ASP A 131
ASP A 146
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.78A 4uckA-3gczA:
9.6		 4uckA-3gczA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 6 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.76A 4uckB-3gczA:
9.6		 4uckB-3gczA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		3 / 3 ARG A 209
THR A 242
TRP A  13
 None
 1.11A 4ug5A-3gczA:
1.3		 4ug5A-3gczA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		3 / 3 ARG A 209
THR A 242
TRP A  13
 None
 1.15A 4uglA-3gczA:
undetectable		 4uglA-3gczA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 7 ALA A  91
ARG A  84
GLY A  83
GLU A 111
 None
SO4  A 268 (-3.4A)
SAM  A4633 (-3.4A)
None
 0.96A 5btdA-3gczA:
undetectable
5btdB-3gczA:
undetectable
5btdC-3gczA:
undetectable		 5btdA-3gczA:
19.09
5btdB-3gczA:
23.24
5btdC-3gczA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 7 ALA A  91
ARG A  84
GLY A  83
GLU A 111
 None
SO4  A 268 (-3.4A)
SAM  A4633 (-3.4A)
None
 1.00A 5btdA-3gczA:
undetectable
5btdC-3gczA:
undetectable
5btdD-3gczA:
undetectable		 5btdA-3gczA:
19.09
5btdC-3gczA:
19.09
5btdD-3gczA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 6 ALA A  91
ARG A  84
GLY A  83
GLU A 111
 None
SO4  A 268 (-3.4A)
SAM  A4633 (-3.4A)
None
 0.95A 5btgA-3gczA:
undetectable
5btgB-3gczA:
undetectable
5btgC-3gczA:
undetectable		 5btgA-3gczA:
19.09
5btgB-3gczA:
23.24
5btgC-3gczA:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.40A 5e9qA-3gczA:
41.0		 5e9qA-3gczA:
50.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.36A 5e9qC-3gczA:
41.0		 5e9qC-3gczA:
50.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.39A 5ec8A-3gczA:
40.8		 5ec8A-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		6 / 12 SER A  56
GLY A  58
GLY A  83
GLY A  86
THR A 104
GLU A 111
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-4.5A)
None
 1.01A 5ec8A-3gczA:
40.8		 5ec8A-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
None
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.42A 5ec8C-3gczA:
40.5		 5ec8C-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.40A 5ehgA-3gczA:
40.9		 5ehgA-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.36A 5ehgC-3gczA:
40.8		 5ehgC-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  58
GLY A  83
GLY A  86
THR A 104
GLU A 111
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-4.5A)
None
 0.96A 5ehgC-3gczA:
40.8		 5ehgC-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
None
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.37A 5ehiA-3gczA:
41.3		 5ehiA-3gczA:
55.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
None
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.36A 5ehiC-3gczA:
40.7		 5ehiC-3gczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.38A 5eifA-3gczA:
41.3		 5eifA-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.34A 5eifC-3gczA:
41.0		 5eifC-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
None
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.47A 5eiwA-3gczA:
41.0		 5eiwA-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.37A 5eiwC-3gczA:
40.9		 5eiwC-3gczA:
55.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.40A 5ekxA-3gczA:
41.2		 5ekxA-3gczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.39A 5ekxB-3gczA:
41.1		 5ekxB-3gczA:
55.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		6 / 12 GLY A  86
TRP A  87
HIS A 110
GLU A 111
ASP A 146
ILE A 147
 SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 1.45A 5ekxB-3gczA:
41.1		 5ekxB-3gczA:
55.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		3 / 3 ARG A 209
THR A 242
TRP A  13
 None
 1.11A 5g6cA-3gczA:
undetectable		 5g6cA-3gczA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.42A 5ikmA-3gczA:
40.2		 5ikmA-3gczA:
54.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 ( 4.2A)
 0.35A 5kqrA-3gczA:
40.9		 5kqrA-3gczA:
54.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.41A 5kqsA-3gczA:
40.7		 5kqsA-3gczA:
54.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 ( 4.2A)
 0.37A 5m5bA-3gczA:
41.1		 5m5bA-3gczA:
55.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_A_SAMA301_0
(NS5)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.37A 5njvA-3gczA:
41.7		 5njvA-3gczA:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_B_SAMB301_0
(NS5)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.34A 5njvB-3gczA:
41.4		 5njvB-3gczA:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_B_SAMB301_0
(NS5)		 3gcz POLYPROTEIN
(Yokose
virus) 		6 / 12 GLY A  86
TRP A  87
HIS A 110
ASP A 131
ASP A 146
ILE A 147
 SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 1.42A 5njvB-3gczA:
41.4		 5njvB-3gczA:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_C_SAMC301_0
(NS5)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.58A 5njvC-3gczA:
40.6		 5njvC-3gczA:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_D_SAMD301_0
(NS5)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
TRP A  87
THR A 104
HIS A 110
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.44A 5njvD-3gczA:
40.9		 5njvD-3gczA:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 183
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.9A)
SAM  A4633 ( 4.2A)
SAM  A4633 ( 4.8A)
 0.51A 5vimA-3gczA:
40.8		 5vimA-3gczA:
56.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAM  A4633 (-2.7A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.33A 5vimA-3gczA:
40.8		 5vimA-3gczA:
56.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 183
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.9A)
SAM  A4633 ( 4.2A)
SAM  A4633 ( 4.8A)
 0.43A 5vimB-3gczA:
40.8		 5vimB-3gczA:
56.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAM  A4633 (-2.7A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.32A 5vimB-3gczA:
40.8		 5vimB-3gczA:
56.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.45A 5wz1A-3gczA:
41.5		 5wz1A-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.65A 5wz1A-3gczA:
41.5		 5wz1A-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 ( 4.2A)
 0.43A 5wz1B-3gczA:
41.5		 5wz1B-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 ( 4.2A)
 0.63A 5wz1B-3gczA:
41.5		 5wz1B-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.47A 5wz1C-3gczA:
41.3		 5wz1C-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.68A 5wz1C-3gczA:
41.3		 5wz1C-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.44A 5wz1D-3gczA:
41.5		 5wz1D-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.67A 5wz1D-3gczA:
41.5		 5wz1D-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		6 / 12 GLY A  86
TRP A  87
HIS A 110
ASP A 131
ASP A 146
ILE A 147
 SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 1.50A 5wz1D-3gczA:
41.5		 5wz1D-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.46A 5wz1E-3gczA:
41.3		 5wz1E-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.65A 5wz1E-3gczA:
41.3		 5wz1E-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.43A 5wz1F-3gczA:
41.5		 5wz1F-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.67A 5wz1F-3gczA:
41.5		 5wz1F-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.45A 5wz1G-3gczA:
41.3		 5wz1G-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.65A 5wz1G-3gczA:
41.3		 5wz1G-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		6 / 12 GLY A  86
TRP A  87
HIS A 110
ASP A 131
ASP A 146
ILE A 147
 SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 1.49A 5wz1G-3gczA:
41.3		 5wz1G-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.45A 5wz1H-3gczA:
41.3		 5wz1H-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
None
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.66A 5wz1H-3gczA:
41.3		 5wz1H-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		6 / 12 GLY A  86
TRP A  87
HIS A 110
ASP A 131
ASP A 146
ILE A 147
 SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 1.48A 5wz1H-3gczA:
41.3		 5wz1H-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.37A 5wz2A-3gczA:
41.1		 5wz2A-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.37A 5wz2B-3gczA:
41.4		 5wz2B-3gczA:
54.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
SAM  A4633 ( 4.2A)
 0.38A 5wz2C-3gczA:
41.2		 5wz2C-3gczA:
54.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3gcz POLYPROTEIN
(Yokose
virus) 		4 / 8 LEU A 207
VAL A 234
VAL A 230
ILE A 192
 None
 0.80A 5y9mA-3gczA:
undetectable		 5y9mA-3gczA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  81
GLY A  86
LEU A 105
ASP A 131
ASP A 146
 SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.90A 5yn6A-3gczA:
10.9		 5yn6A-3gczA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  81
GLY A  86
LEU A 105
ASP A 131
ASP A 146
 SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.90A 5yniA-3gczA:
11.0		 5yniA-3gczA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 12 GLY A  81
GLY A  86
LEU A 105
ASP A 131
ASP A 146
 SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.85A 5ynmA-3gczA:
11.2		 5ynmA-3gczA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 9 VAL A  71
GLY A  58
TYR A 221
MET A  65
ASP A 146
 None
SAM  A4633 (-3.5A)
None
None
SAM  A4633 (-3.7A)
 1.34A 5zncA-3gczA:
undetectable		 5zncA-3gczA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3gcz POLYPROTEIN
(Yokose
virus) 		5 / 11 SER A  59
GLY A  81
GLY A  83
LEU A 105
ASP A 131
 SAM  A4633 ( 4.9A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.7A)
 1.07A 6i5zD-3gczA:
6.4		 6i5zD-3gczA:
20.67