SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		4 / 4 LYS A 179
LEU A 175
ALA A 178
LEU A 174
 None
 1.27A 1f86A-3gd5A:
undetectable		 1f86A-3gd5A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 12 PRO A 194
THR A 188
ILE A 184
ALA A 200
SER A 203
 None
 1.49A 1fm4A-3gd5A:
undetectable		 1fm4A-3gd5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 11 LEU A  30
LEU A 145
ALA A 211
VAL A 142
LEU A  19
 None
 1.19A 1kt6A-3gd5A:
undetectable		 1kt6A-3gd5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 11 LEU A  30
LEU A 145
ALA A 211
VAL A 142
LEU A  19
 None
 1.19A 1kt7A-3gd5A:
undetectable		 1kt7A-3gd5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 10 LEU A  53
ARG A 110
PHE A  55
THR A  62
ALA A  58
 None
 1.30A 1wygA-3gd5A:
undetectable		 1wygA-3gd5A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_B_SALB3006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		4 / 4 ARG A 110
PHE A  55
THR A  62
ALA A  58
 None
 1.39A 2e1qB-3gd5A:
0.0		 2e1qB-3gd5A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		4 / 5 ARG A 110
PHE A  55
THR A  62
ALA A  58
 None
 1.43A 2e1qD-3gd5A:
undetectable		 2e1qD-3gd5A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		6 / 12 GLY A  48
GLY A 106
GLY A  75
ASP A  15
ASP A 105
ILE A 126
 None
 1.24A 2pxcA-3gd5A:
3.6		 2pxcA-3gd5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		4 / 4 LYS A 179
LEU A 175
ALA A 178
LEU A 174
 None
 1.25A 2roxA-3gd5A:
undetectable		 2roxA-3gd5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		4 / 7 VAL A  77
ALA A  69
MET A  70
LEU A  73
 None
 0.77A 2wekB-3gd5A:
8.1		 2wekB-3gd5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 10 ALA A 211
ILE A 184
ILE A 215
PRO A 194
THR A 209
 None
 1.25A 3clbD-3gd5A:
2.2		 3clbD-3gd5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 10 ALA A 211
ILE A 184
ILE A 215
PRO A 194
THR A 209
 None
 1.22A 3hbbD-3gd5A:
undetectable		 3hbbD-3gd5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		3 / 3 GLU A 150
LEU A 146
LEU A 160
 None
 0.75A 3ohtA-3gd5A:
undetectable		 3ohtA-3gd5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		3 / 3 GLU A 150
LEU A 146
LEU A 160
 None
 0.75A 3ohtB-3gd5A:
undetectable		 3ohtB-3gd5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 9 LYS A 179
LEU A 175
THR A 209
ALA A 178
LEU A 174
 None
 1.22A 3ozkA-3gd5A:
undetectable		 3ozkA-3gd5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 12 ARG A 208
GLY A 181
GLY A 210
GLU A  24
ALA A 178
 None
 1.23A 3sxjA-3gd5A:
3.4		 3sxjA-3gd5A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 12 ARG A 208
GLY A 181
GLY A 210
GLU A  24
ALA A 178
 None
 1.22A 3sxjB-3gd5A:
3.2		 3sxjB-3gd5A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 12 ARG A 208
GLY A 181
GLY A 210
GLU A  24
ALA A 178
 None
 1.27A 3t7sD-3gd5A:
6.6		 3t7sD-3gd5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		4 / 7 ARG A 217
ALA A 187
ILE A 215
GLY A 166
 None
 0.91A 3v4tH-3gd5A:
undetectable		 3v4tH-3gd5A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		6 / 12 GLY A  48
GLY A 106
GLY A  75
ASP A  15
ASP A 105
ILE A 126
 None
 1.27A 4ctkA-3gd5A:
4.5		 4ctkA-3gd5A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		4 / 5 ALA A 222
ILE A 184
LEU A 160
LYS A 159
 None
 1.07A 4g19A-3gd5A:
undetectable		 4g19A-3gd5A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 8 LYS A 179
LEU A 175
THR A 209
ALA A 178
LEU A 174
 None
 1.19A 4ik7B-3gd5A:
undetectable		 4ik7B-3gd5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		3 / 3 SER A 183
ALA A 185
VAL A 186
 None
 0.64A 4o2bC-3gd5A:
undetectable		 4o2bC-3gd5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 6 LYS A 179
LEU A 175
THR A 209
ALA A 178
LEU A 174
 None
 1.37A 4pwjA-3gd5A:
undetectable		 4pwjA-3gd5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		3 / 3 SER A 183
ALA A 185
VAL A 186
 None
 0.56A 4x1iA-3gd5A:
undetectable		 4x1iA-3gd5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 12 ILE A 129
LEU A 132
PHE A  66
THR A  62
LEU A  30
 None
 1.07A 5byjA-3gd5A:
undetectable		 5byjA-3gd5A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 12 ILE A 129
LEU A 132
VAL A 142
PHE A  66
THR A  62
 None
 1.24A 5bykA-3gd5A:
undetectable		 5bykA-3gd5A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 12 GLY A  52
GLY A 106
GLY A 101
LEU A 100
LEU A  53
 None
 1.11A 5c0oE-3gd5A:
8.1		 5c0oE-3gd5A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		6 / 12 GLY A  48
GLY A 106
GLY A  75
ASP A  15
ASP A 105
ILE A 126
 None
 1.24A 5e9qA-3gd5A:
3.7		 5e9qA-3gd5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		6 / 12 GLY A  48
GLY A 106
GLY A  75
ASP A  15
ASP A 105
ILE A 126
 None
 1.24A 5ehgA-3gd5A:
4.5		 5ehgA-3gd5A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		3 / 3 SER A 183
ALA A 185
VAL A 186
 None
 0.57A 5eypA-3gd5A:
undetectable		 5eypA-3gd5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 10 ALA A 178
VAL A 180
ILE A 148
ILE A 228
ALA A 211
 None
 1.10A 5nukA-3gd5A:
undetectable		 5nukA-3gd5A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 9 ALA A 178
VAL A 180
ILE A 148
ILE A 228
ALA A 211
 None
 1.00A 5nunA-3gd5A:
undetectable		 5nunA-3gd5A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 9 ALA A 178
VAL A 180
LEU A 155
ILE A 148
ILE A 228
 None
 0.99A 5nunA-3gd5A:
undetectable		 5nunA-3gd5A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		5 / 10 VAL A 163
GLY A 164
GLY A 166
ILE A 215
LEU A 216
 None
 0.94A 5vm8B-3gd5A:
2.7		 5vm8B-3gd5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		6 / 12 GLY A  48
GLY A 106
GLY A  75
ASP A  15
ASP A 105
ILE A 126
 None
 1.27A 5wz1A-3gd5A:
3.6		 5wz1A-3gd5A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		6 / 12 GLY A  48
GLY A 106
GLY A  75
ASP A  15
ASP A 105
ILE A 126
 None
 1.31A 5wz1D-3gd5A:
4.0		 5wz1D-3gd5A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		6 / 12 GLY A  48
GLY A 106
GLY A  75
ASP A  15
ASP A 105
ILE A 126
 None
 1.33A 5wz1F-3gd5A:
3.9		 5wz1F-3gd5A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		6 / 12 GLY A  48
GLY A 106
GLY A  75
ASP A  15
ASP A 105
ILE A 126
 None
 1.31A 5wz1G-3gd5A:
3.9		 5wz1G-3gd5A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3gd5 ORNITHINE
CARBAMOYLTRANSFERASE
(Gloeobacter
violaceus) 		4 / 6 ASP A 144
VAL A 141
GLU A 296
ALA A 275
 None
 0.90A 6djzB-3gd5A:
undetectable		 6djzB-3gd5A:
20.38