SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gd8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		5 / 12 ILE A 189
GLY A  93
GLY A  89
ALA A 190
ALA A  37
 GOL  A   4 (-3.7A)
None
GOL  A   4 ( 3.8A)
GOL  A   4 (-3.4A)
None
 1.05A 2yvlA-3gd8A:
undetectable		 2yvlA-3gd8A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		5 / 12 ILE A 189
GLY A  93
GLY A  89
ALA A 190
ALA A  37
 GOL  A   4 (-3.7A)
None
GOL  A   4 ( 3.8A)
GOL  A   4 (-3.4A)
None
 1.07A 2yvlB-3gd8A:
undetectable		 2yvlB-3gd8A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		5 / 12 SER A 217
GLU A 163
PRO A 237
GLY A 200
ILE A 205
 None
None
None
None
GOL  A   6 ( 4.5A)
 1.45A 3jb2A-3gd8A:
undetectable		 3jb2A-3gd8A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		4 / 8 THR A 137
LEU A 145
GLY A 146
THR A  56
 None
None
GOL  A   1 ( 3.4A)
GOL  A   6 (-4.2A)
 0.80A 4c9nA-3gd8A:
undetectable		 4c9nA-3gd8A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		5 / 12 LEU A  46
LEU A 135
GLY A 131
ALA A 130
LEU A  53
 None
 1.08A 4rrwD-3gd8A:
undetectable		 4rrwD-3gd8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		5 / 12 LEU A  46
LEU A 135
GLY A 131
ALA A 130
LEU A  53
 None
 1.08A 4rrzD-3gd8A:
undetectable		 4rrzD-3gd8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		4 / 5 PHE A 218
PRO A 220
VAL A 222
ALA A 126
 None
 1.34A 4z4dA-3gd8A:
undetectable		 4z4dA-3gd8A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		4 / 5 PHE A 218
PRO A 220
VAL A 222
ALA A 126
 None
 1.32A 4z4eA-3gd8A:
undetectable		 4z4eA-3gd8A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		5 / 12 ILE A 110
ALA A  99
THR A 167
ALA A 244
GLU A 249
 None
 1.28A 5vcgA-3gd8A:
undetectable		 5vcgA-3gd8A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		5 / 12 LEU A  50
GLY A 125
GLY A 129
PHE A  48
LEU A  43
 None
 1.02A 6ectA-3gd8A:
undetectable		 6ectA-3gd8A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3gd8 AQUAPORIN-4
(Homo
sapiens) 		5 / 12 LEU A  50
GLY A 125
GLY A 129
PHE A  48
LEU A  43
 None
 1.01A 6ecxA-3gd8A:
undetectable		 6ecxA-3gd8A:
23.55