SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gdb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q72_H_COCH401_1
(FAB M82G2, HEAVY
CHAIN
FAB M82G2, LIGHT
CHAIN)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 10 TRP A 264
ASN A 231
VAL A 262
GLY A 286
TYR A 373
 None
 1.38A 1q72H-3gdbA:
3.9
1q72L-3gdbA:
1.9		 1q72H-3gdbA:
13.47
1q72L-3gdbA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 5 ALA A 515
TYR A 254
ILE A 514
ASP A 491
 None
 1.15A 1upfC-3gdbA:
undetectable		 1upfC-3gdbA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 7 LEU A 698
THR A 699
GLY A 786
ASP A 739
 None
 0.97A 2ddwB-3gdbA:
undetectable		 2ddwB-3gdbA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 7 ASN A 735
GLY A 734
THR A 711
SER A 792
 None
 1.16A 2o5yH-3gdbA:
5.0
2o5yL-3gdbA:
4.9		 2o5yH-3gdbA:
13.88
2o5yL-3gdbA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 12 SER A 260
PHE A 494
PHE A 409
GLU A 178
GLU A 265
 None
 1.43A 3aocC-3gdbA:
undetectable		 3aocC-3gdbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 12 THR A 619
VAL A 525
GLY A 526
THR A 674
ILE A 675
 None
 0.97A 3bf1A-3gdbA:
undetectable
3bf1B-3gdbA:
undetectable		 3bf1A-3gdbA:
13.84
3bf1B-3gdbA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 6 TRP A 255
ARG A 279
VAL A 205
HIS A 278
 None
 1.38A 3deuA-3gdbA:
undetectable		 3deuA-3gdbA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB302_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 5 TRP A 255
ARG A 279
VAL A 205
HIS A 278
 None
 1.44A 3deuB-3gdbA:
0.0		 3deuB-3gdbA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 4 ASP A 401
GLY A 400
LYS A 402
GLU A 399
 None
 1.31A 3hznD-3gdbA:
undetectable		 3hznD-3gdbA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 4 PRO A 269
THR A 270
GLY A 536
THR A 535
 None
 1.17A 3ib1A-3gdbA:
undetectable		 3ib1A-3gdbA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		3 / 3 GLN A 692
GLU A 579
LYS A 593
 None
 1.14A 3su9A-3gdbA:
undetectable		 3su9A-3gdbA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 10 GLY A 277
ALA A 208
GLY A 281
VAL A 205
VAL A 561
 None
 1.05A 4c5lC-3gdbA:
2.6		 4c5lC-3gdbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 10 GLY A 277
ALA A 208
GLY A 281
VAL A 205
VAL A 561
 None
 1.07A 4c5lD-3gdbA:
3.2		 4c5lD-3gdbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 10 GLY A 277
ALA A 208
GLY A 281
VAL A 205
VAL A 561
 None
 1.01A 4c5nB-3gdbA:
3.4		 4c5nB-3gdbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 8 ASN A 280
GLY A 560
VAL A 561
PHE A 582
 None
 0.94A 4fglD-3gdbA:
undetectable		 4fglD-3gdbA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 4 THR A 232
GLU A 265
ARG A 556
HIS A 239
 None
 1.34A 4hvcA-3gdbA:
0.0		 4hvcA-3gdbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 5 THR A 232
GLU A 265
ARG A 556
HIS A 239
 None
 1.33A 4hvcB-3gdbA:
undetectable		 4hvcB-3gdbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		3 / 3 TYR A 643
ARG A 211
SER A 610
 None
 1.08A 4khpI-3gdbA:
undetectable
4khpJ-3gdbA:
undetectable		 4khpI-3gdbA:
9.54
4khpJ-3gdbA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 12 ALA A 585
PHE A 533
LEU A 680
VAL A 606
LEU A 608
 None
 0.80A 4km2B-3gdbA:
undetectable		 4km2B-3gdbA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 9 SER A 478
ALA A 472
LEU A 442
GLY A 446
ALA A 224
 None
 1.40A 4l6va-3gdbA:
undetectable
4l6vf-3gdbA:
undetectable		 4l6va-3gdbA:
21.37
4l6vf-3gdbA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 7 SER A 758
ALA A 276
SER A 559
ARG A 556
 None
 1.26A 4lv9A-3gdbA:
3.8
4lv9B-3gdbA:
4.8		 4lv9A-3gdbA:
19.02
4lv9B-3gdbA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 12 TRP A 751
THR A 797
THR A 796
ALA A 795
ALA A 794
 None
 1.05A 4u15A-3gdbA:
undetectable		 4u15A-3gdbA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 12 LEU A 464
VAL A 518
ILE A 514
TRP A 454
LEU A 440
 None
 1.32A 4yvpB-3gdbA:
3.6		 4yvpB-3gdbA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		3 / 3 THR A 564
HIS A 625
LEU A 680
 None
 0.87A 5axdC-3gdbA:
undetectable		 5axdC-3gdbA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 7 LEU A 562
GLU A 579
ILE A 476
LYS A 488
 None
 1.14A 5jh7C-3gdbA:
2.1		 5jh7C-3gdbA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 11 ASN A 590
VAL A 561
ASP A 253
THR A 535
TYR A 609
 None
 1.31A 5jh7D-3gdbA:
2.3		 5jh7D-3gdbA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 5 ALA A 228
VAL A 226
PHE A 252
ILE A 514
 None
 0.90A 5of1A-3gdbA:
undetectable		 5of1A-3gdbA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 5 ALA A 228
VAL A 226
PHE A 252
ILE A 514
 None
 0.85A 5of1B-3gdbA:
4.0		 5of1B-3gdbA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 6 GLN A 731
PHE A 732
PHE A 713
LEU A 780
 None
 1.11A 5zcoP-3gdbA:
undetectable
5zcoW-3gdbA:
undetectable		 5zcoP-3gdbA:
12.65
5zcoW-3gdbA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 6 GLN A 731
PHE A 732
PHE A 713
LEU A 780
 None
 1.11A 5zcpC-3gdbA:
undetectable
5zcpJ-3gdbA:
undetectable		 5zcpC-3gdbA:
12.65
5zcpJ-3gdbA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 12 VAL A 623
LEU A 562
LEU A 592
ARG A 279
GLY A 789
 None
 1.10A 6b0iB-3gdbA:
undetectable		 6b0iB-3gdbA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		5 / 12 VAL A 623
LEU A 562
LEU A 592
ARG A 279
GLY A 789
 None
 1.07A 6b0lB-3gdbA:
undetectable		 6b0lB-3gdbA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 8 THR A 760
THR A 755
LYS A 549
SER A 557
 None
 1.07A 6c06C-3gdbA:
undetectable		 6c06C-3gdbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 6 PHE A 693
LEU A 698
LEU A 695
HIS A 625
 None
 1.00A 6e43A-3gdbA:
1.3		 6e43A-3gdbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 6 PHE A 693
LEU A 698
LEU A 695
HIS A 625
 None
 1.02A 6e43B-3gdbA:
undetectable		 6e43B-3gdbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 6 PHE A 693
LEU A 698
LEU A 695
HIS A 625
 None
 1.01A 6e43C-3gdbA:
undetectable		 6e43C-3gdbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_1
(UNCHARACTERIZED
PROTEIN)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		4 / 4 THR A 232
GLU A 265
ARG A 556
HIS A 239
 None
 1.32A 6mn8A-3gdbA:
undetectable		 6mn8A-3gdbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440
(Streptococcus
pneumoniae) 		3 / 3 ASP A 749
SER A 772
SER A 770
 None
 0.68A 6mxtA-3gdbA:
undetectable		 6mxtA-3gdbA:
18.53